Volume 20 Issue 2
Feb.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(2): 298-301, 351
LI Yong, GUO Min, KANG Ying-ying. Research progress of microRNA in thyroid cancer[J]. Chinese Journal of General Practice, 2022, 20(2): 298-301, 351. doi: 10.16766/j.cnki.issn.1674-4152.002337
Citation: LI Yong, GUO Min, KANG Ying-ying. Research progress of microRNA in thyroid cancer[J]. Chinese Journal of General Practice, 2022, 20(2): 298-301, 351. doi: 10.16766/j.cnki.issn.1674-4152.002337
shu

Research progress of microRNA in thyroid cancer

doi: 10.16766/j.cnki.issn.1674-4152.002337

  • Department of Endocrinology, the Fourth Affiliated Hospital of Harbin, Harbin, Heilongjiang 150001, China

Funds:

 2018096

 LH2019H017

  • Received Date: 2021-04-02
    Available Online: 2022-03-04
    Abstract
  • MiRNAs are short, single-stranded non-coding RNAs that exist in organisms widely and can regulate a lot of pathological and physiological processes. It is also differentially expressed in blood, urine and exosomes outside tissues. With the rapid development of detection technology, continuous improvement of research methods and continuous improvement of researcher' operational skills, miRNA has entered people' sight due to its stable molecular structure and abundant biological functions. Its differential expression and specific regulatory mechanisms in life processes such as inflammation, immune regulation, oxidative stress, fibrosis, information transmission, virus dissemination and tumor malignant progression are constantly being explored and confirmed, especially in the regulation of thyroid's occurrence, invasion, metastasis and drug resistance, indicating that it's expected to become a new indicator for precise diagnosis, treatment and prognosis evaluation of thyroid cancer. Furthermore, the research on miRNAs of their unknown functions and specific expression in different types of thyroid cancer is not only of great significance for diagnosis, identification and treatment of different pathological types of thyroid cancer, but also helps to dynamically observe the condition evolution of patients with thyroid cancer. This review summarizes the research progress, biology function of miRNA and its recent researches in different types of thyroid cancer, aiming to provide references for the diagnosis and treatment of thyroid cancer, enrich the diagnosis and treatment strategies for patients with thyroid cancer and improve the quality of their lives furtherly.

     

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