Volume 20 Issue 3
Mar.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 493-497
YAN Yan-yan, WU Wan-ying, FU Huan-ying, YU Peng-fei. Influencing factors of hypoglycaemia in post-operative total parenteral nutrition therapy for gastric cancer[J]. Chinese Journal of General Practice, 2022, 20(3): 493-497. doi: 10.16766/j.cnki.issn.1674-4152.002385
Citation: YAN Yan-yan, WU Wan-ying, FU Huan-ying, YU Peng-fei. Influencing factors of hypoglycaemia in post-operative total parenteral nutrition therapy for gastric cancer[J]. Chinese Journal of General Practice, 2022, 20(3): 493-497. doi: 10.16766/j.cnki.issn.1674-4152.002385
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Influencing factors of hypoglycaemia in post-operative total parenteral nutrition therapy for gastric cancer

doi: 10.16766/j.cnki.issn.1674-4152.002385

  • Department of Abdominal Surgery, the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310012, China

Funds:

 LY18H160032

  • Received Date: 2021-03-29
    Available Online: 2022-08-13
    Abstract
  •   Objective  To explore the related factors of hypoglycaemia in patients with gastric cancer during total parenteral nutrition therapy and to provide a theoretical basis for reducing the incidence of hypoglycaemia in clinical treatment and for medical staff to formulate effective prevention and intervention measures.  Methods  A retrospective study was used to collect information on 974 patients who underwent radical gastric cancer surgery in the Department of Abdominal Surgery of the Tumor Hospital of the University of Chinese Academy of Sciences from January 1, 2018 to December 31, 2019. According to whether or not hypoglycaemia occurred, they were divided into hypoglycaemia group and non-hypoglycaemia group. The hypoglycaemia group was the observation group (126 cases), and the non-hypoglycaemia group was the control group (848 cases). The two groups compared their age, gender, past history, BMI, surgical methods, medication status and biochemical indicators. Univariate analysis was performed using t test and χ2 test. Multivariate analysis adopted binary logistic regression analysis.  Results  A total of 974 patients were enrolled in this study, including 660 males (67.8%) and 314 females (32.2%), with an average age of (61.2±10.5) years. A total of 126 cases of hypoglycaemia were reported, with an incidence of 12.9%. Binary logistic regression analysis showed that gender, BMI, previous diabetes history, insulin and glucose ratio were related to the occurrence of hypoglycaemia during total parenteral nutrition therapy in patients after gastric cancer surgery.  Conclusion  In nursing care, attention should be paid to high-risk groups, and targeted measures should be taken to improve the nutritional status of patients, use drugs safely and rationally, reduce post-operative stress and fasting time and reduce the incidence of hypoglycaemia.

     

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    • References(18)
  • [1]
    李磊, 刘鹏, 李明, 等. 胰岛素在多腔袋肠外营养液中的稳定性研究[J]. 中华损伤与修复杂志(电子版), 2020, 15(3): 231-234. doi: 10.3877/cma.j.issn.1673-9450.2020.03.017

    LI L, LIU P, LI M, et al. Experimental study on the stability of insulin in parenteral nutrition in multi-cavity bag[J]. Chinese Journal of Injury Repair and Wound Healing (Electronic Edition), 2020, 15(3): 231-234. doi: 10.3877/cma.j.issn.1673-9450.2020.03.017
    [2]
    FREEMAN J. Management of hypoglycemia in older adults with type 2 diabetes[J]. Postgrad Med, 2019, 131(4): 241-250. doi: 10.1080/00325481.2019.1578590
    [3]
    尹建红, 刘鸣, 孙莉, 等. 多学科协作模式在非内分泌科2型糖尿病病人围术期血糖管理中的应用观察[J]. 护理研究, 2019, 33(24): 4308-4311. https://www.cnki.com.cn/Article/CJFDTOTAL-SXHZ201924025.htm

    YIN J H, LIU M, SUN L, et al. Application observation of MDT mode in blood glucose management of perioperative patients with non-endocrine type 2 diabetes[J]. Chinese Nursing Research, 2019, 33(24): 4308-4311. https://www.cnki.com.cn/Article/CJFDTOTAL-SXHZ201924025.htm
    [4]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中国实用内科杂志, 2018, 38(4): 292-344. https://www.cnki.com.cn/Article/CJFDTOTAL-SYNK201804009.htm

    Diabetes Society of Chinese Medical Association. Guidelines for the prevention and control of type 2 diabetes in China (2017 Edition)[J]. Chinese Journal of Practical Internal Medicine, 2018, 38(4): 292-344. https://www.cnki.com.cn/Article/CJFDTOTAL-SYNK201804009.htm
    [5]
    张阳敏, 汪寅, 陆丽霞. 老年2型糖尿病住院患者发生严重低血糖的相关危险因素[J]. 中国老年学杂志, 2015, 35(16): 4557-4559. doi: 10.3969/j.issn.1005-9202.2015.16.061

    ZHANG Y M, WANG Y, LU L X. Risk factors for severe hypoglycemia in elderly hospitalized patients with type 2 diabetes mellitus[J]. Chinese Journal of Gerontology, 2015, 35(16): 4557-4559. doi: 10.3969/j.issn.1005-9202.2015.16.061
    [6]
    RAPARELLI V, MORANO S, FRANCONI F, et al. Sex differences in type-2 diabetes: Implications for cardiovascular risk management[J]. Curr Pharm Des, 2017, 23(10): 1471-1476. doi: 10.2174/1381612823666170130153704
    [7]
    EDRIDGE C L, DUNKLEY A J, BODICOAT D H, et al. Prevalence and incidence of hypoglycaemia in 532, 542 people with type 2 diabetes on oral therapies and insulin: A systematic review and meta-analysis of population based studies[J]. PLoS One, 2015, 10(6): e0126427. doi: 10.1371/journal.pone.0126427
    [8]
    马婧, 谭翠霞, 钟莉, 等. 应用动态血糖监测系统评估血糖控制良好2型糖尿病患者的低血糖[J]. 中华糖尿病杂志, 2017, 9(7): 428-434. doi: 10.3760/cma.j.issn.1674-5809.2017.07.006

    MA J, TAN C X, ZHONG L, et al. Evaluation of hypoglycemia in type 2 diabetic patients with well-controlled glucose levels by continuous glucose monitoring system[J]. Chinese Journal of Diabetes Mellitus, 2017, 9(7): 428-434. doi: 10.3760/cma.j.issn.1674-5809.2017.07.006
    [9]
    RUAN Y, TAN G D, LUMB A, et al. Importance of inpatient hypoglycaemia: Impact, prediction and prevention[J]. Diabet Med, 2019, 36(4): 434-443. doi: 10.1111/dme.13897
    [10]
    KNAAK C, WOLLERSHEIM T, MÖRGELI R, et al. Risk factors of intraoperative dysglycemia in elderly surgical patients[J]. Int J Med Sci, 2019, 16(5): 665-674. doi: 10.7150/ijms.32971
    [11]
    青丽, 彭璐婷, 刘倩琦, 等. 肥胖儿童青少年胰岛素抵抗的临床特征及其与代谢并发症的关系[J]. 中华实用儿科临床杂志, 2020, 35(11): 847-851. doi: 10.3760/cma.j.cn101070-20190214-00101

    QING L, PENG L T, LIU Q Y, et al. Clinical characteristics of insulin resistance and its relationship with metabolic complications in obese children and adolescents[J]. Chinese Journal of Applied Clinical Pediatrics, 2020, 35(11): 847-851. doi: 10.3760/cma.j.cn101070-20190214-00101
    [12]
    张海燕, 王宁, 刘静. 社区老年糖尿病患者低血糖风险评估模型的建立及应用价值分析[J]. 中国医师杂志, 2019, 21(2): 247-250. doi: 10.3760/cma.j.issn.1008-1372.2019.02.022

    ZHANG H Y, WANG N, LIU J. Establishment of hypoglycemia risk assessment model for elderly diabetic patients in community and its application value analysis[J]. Journal of Chinese Physician, 2019, 21(2): 247-250. doi: 10.3760/cma.j.issn.1008-1372.2019.02.022
    [13]
    TSAI T C, LEE C H, CHENG B C, et al. Body mass index-mortality relationship in severe hypoglycemic patients with type 2 diabetes[J]. Am J Med Sci, 2015, 349(3): 192-198. doi: 10.1097/MAJ.0000000000000382
    [14]
    宋新霞. 99例胃癌患者营养现状及营养支持治疗的调查研究[D]. 石家庄: 河北医科大学, 2015.

    SONG X X. Investigation of nutritional status and nutritional support therapy in 99 patients with gastric cancer[D]. Shijiazhuang: Hebei Medical University, 2015.
    [15]
    金百翰, 宋敬云, 谢俊豪, 等. 门诊2型糖尿病患者行动态血糖监测的临床价值及影响因素[J]. 中国糖尿病杂志, 2019, 27(1): 11-15. doi: 10.3969/j.issn.1006-6187.2019.01.004

    JIN B H, SONG J Y, XIE J H, et al. Clinical value and influencing factors of continuous glucose monitoring on glycemic control in outpatients with type 2 diabetes mellitus[J]. Chinese Journal of Diabetes, 2019, 27(1): 11-15. doi: 10.3969/j.issn.1006-6187.2019.01.004
    [16]
    党芳萍, 田金徽, 李惠菊. 不同营养支持方式对脑卒中吞咽障碍病人有效性的Meta分析[J]. 循证护理, 2019, 5(3): 203-211. https://www.cnki.com.cn/Article/CJFDTOTAL-XZHL201903003.htm

    DANG F P, TIAN J H, LI H J. Meta-analysis of effect of different nutrition therapies for dysphagia patients of stroke[J]. Chinese Evidence-Based Nursing, 2019, 5(3): 203-211. https://www.cnki.com.cn/Article/CJFDTOTAL-XZHL201903003.htm
    [17]
    全信保, 邹佩钢, 杨学军, 等. 2型糖尿病合并胃肠道肿瘤术后肠内外营养支持的疗效观察[J]. 西部医学, 2018, 30(2): 264-267. doi: 10.3969/j.issn.1672-3511.2018.02.028

    QUAN X B, ZOU P G, YANG X J, et al. Comparative study of the enteral and parenteral nutrition with type 2 diabetic patients after gastrointestinal tumor surgery[J]. Medical Journal of West China 2018, 30(2): 264-267. doi: 10.3969/j.issn.1672-3511.2018.02.028
    [18]
    白春花, 陈莉, 傅巧美. 不同胰岛素输注方式在肠外营养中应用效果的Meta分析[J]. 解放军护理杂志2018, 35(23): 27-32, 36. doi: 10.3969/j.issn.1008-9993.2018.23.006

    BAI C H, CHEN L, FU Q M. Different insulin regimens in patients with parenteral nutrition support: A network meta-analysis[J]. Nursing Journal of Chinese People's Liberation Army, 2018, 35(23): 27-32, 36. doi: 10.3969/j.issn.1008-9993.2018.23.006
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