Volume 20 Issue 4
Apr.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 546-549
ZHONG Chong-xia, LIU Yi-hai, FANG Qi-jun, SHA Du-juan, KANG Li-na, XU Biao, NI Jie. Prognostic value of apolipoprotein A1 in elderly patients with ischemic cardiomyopathy and heart failure[J]. Chinese Journal of General Practice, 2022, 20(4): 546-549. doi: 10.16766/j.cnki.issn.1674-4152.002397
Citation: ZHONG Chong-xia, LIU Yi-hai, FANG Qi-jun, SHA Du-juan, KANG Li-na, XU Biao, NI Jie. Prognostic value of apolipoprotein A1 in elderly patients with ischemic cardiomyopathy and heart failure[J]. Chinese Journal of General Practice, 2022, 20(4): 546-549. doi: 10.16766/j.cnki.issn.1674-4152.002397
shu

Prognostic value of apolipoprotein A1 in elderly patients with ischemic cardiomyopathy and heart failure

doi: 10.16766/j.cnki.issn.1674-4152.002397
  • 1.

    Department of Cardiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China

Funds:

 82100398

  • Received Date: 2021-12-17
    Available Online: 2022-08-20
    Abstract
  •   Objective  To observe the level of serum apolipoprotein A1 (apoA1) in elderly patients with ischemic cardiomyopathy and heart failure, and to explore the prognostic value of serum apoA1 in elderly patients with ischemic cardiomyopathy and heart failure.  Methods  Elderly patients with ischemic cardiomyopathy and heart failure hospitalized in the Cardiology Department of Nanjing Drum Tower Hospital from March 2018 to December 2019 were selected retrospectively. The end events were followed up by telephone. The patients were divided into two groups according to whether cardiac death occurred or not. The baseline data (age, gender, BMI, etc.), serological indexes (BNP, apoA1, HDL-C, etc.) and imaging indexes (echocardiography) of different subgroups were compared.  Results  A total of 105 patients were included, of which 9 cases (8.7%) had cardiac death during follow-up. The age, gender, blood pressure, heart rate, BMI, smoking and drinking history, complications and medication history were compared between the two groups. It was found that the mortality rate of patients with higher the New York Heart Association (NYHA) grade and digoxin medication history increased (P < 0.05), but there was no significant difference in the rest between the two groups. Univariate analysis showed that the increase of BNP and globulin and the decrease of HDL-C and apoA1 were possible prognostic factors in the group of cardiac death (P < 0.05). Multivariate logistic regression analysis showed that apoA1 was an independent risk factor for cardiac death (OR < 0.001, P=0.007). The patients were divided into low value group and high value group according to the level of apoA1. It was found that the low value group had a higher level of C-reactive protein (t=3.505, P < 0.01). The ROC curve of globulin, HDL cholesterol, apoA1, BNP was drawn together, and area under ROC curve was 0.863, indicating the preferable prediction effect of the model.  Conclusion  ApoA1 is an independent risk factor for cardiac death in elderly patients with ischemic cardiomyopathy and heart failure.

     

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