Volume 20 Issue 4
Apr.  2022
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LIU Ya-kui, WANG Shuan-hu. Comparative analysis on the clinicopathological characteristics and prognosis of left and right colon cancer at stage Ⅰ-Ⅲ[J]. Chinese Journal of General Practice, 2022, 20(4): 587-590. doi: 10.16766/j.cnki.issn.1674-4152.002406
Citation: LIU Ya-kui, WANG Shuan-hu. Comparative analysis on the clinicopathological characteristics and prognosis of left and right colon cancer at stage Ⅰ-Ⅲ[J]. Chinese Journal of General Practice, 2022, 20(4): 587-590. doi: 10.16766/j.cnki.issn.1674-4152.002406
shu

Comparative analysis on the clinicopathological characteristics and prognosis of left and right colon cancer at stage Ⅰ-Ⅲ

doi: 10.16766/j.cnki.issn.1674-4152.002406

  • Department of Gastrointestinal Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2020ZD87

 BYKC201909

  • Received Date: 2022-10-12
    Available Online: 2022-08-20
    Abstract
  •   Objective  To compare and analyse the clinicopathological characteristics and prognosis of patients with colon cancer at different stages and locations after radical resection.  Methods  The clinicopathological data of 476 patients undergoing radical surgery in the First Affiliated Hospital of Bengbu Medical College from January 2011 to December 2015 were retrospectively analysed. According to the different tumour locations, they were divided into the left colon cancer group (LCC group, 257 patients) and right colon cancer group (RCC group, 219 patients). The clinicopathological characteristics and 5-year overall survival rate of the two groups were compared, and the prognostic relationship of colon cancer patients of different stages and locations was analysed.  Results  The proportion of males was higher than that of females (57.78% vs. 42.22%). Compared with the RCC group, the proportion of males in the LCC group was higher. The proportion of females in the RCC group was higher than that in the LCC group. Compared with the LCC group, the RCC group mainly had anaemia, abdominal mass, larger tumour diameters and moderately and poorly differentiated adenocarcinoma. The proportion of mucinous adenocarcinoma and signet ring cell carcinoma was high, the difference was statistically significant (P < 0.05). In the LCC group, haematochezia and changes in defecation habits were the first main clinical symptoms. There was no statistical difference between the two groups in terms of pTNM stage, pT stage and pN stage (all P>0.05). The 5-year overall survival rates of the LCC and RCC groups were 66.36% and 64.29%, respectively (P>0.05). In stage Ⅰ cancers, the 5-year overall survival rates of the LCC and RCC groups were 86.96% and 83.33%, respectively (P>0.05). In pTNM stage Ⅱ and Ⅲ cancers, the 5-year overall survival rates of the LCC group were 65.89% and 59.68%, respectively, whereas those of the RCC group were 76.64% and 44.16% (all P < 0.05), respectively.  Conclusion  There are differences between the clinical manifestations and pathological characteristics of LCC and RCC. There is no significant difference in the 5-year overall survival rate between the two groups. Through the analysis of subgroups, the prognosis of colon cancer patients of different stages and different parts is different.

     

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