Efficacy of the treatment with ultrasonic debridement combined with RhEGF in patients with perianal abscess infection

XU Chao-hui; ZHOU Le; JIANG Sheng-hua; XU Bao-cai; SHEN Zhong

doi:10.16766/j.cnki.issn.1674-4152.002408

Volume 20 Issue 4

Apr. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(4): 594-597

XU Chao-hui, ZHOU Le, JIANG Sheng-hua, XU Bao-cai, SHEN Zhong. Efficacy of the treatment with ultrasonic debridement combined with RhEGF in patients with perianal abscess infection[J]. Chinese Journal of General Practice, 2022, 20(4): 594-597. doi: 10.16766/j.cnki.issn.1674-4152.002408

Citation:

XU Chao-hui, ZHOU Le, JIANG Sheng-hua, XU Bao-cai, SHEN Zhong. Efficacy of the treatment with ultrasonic debridement combined with RhEGF in patients with perianal abscess infection[J]. Chinese Journal of General Practice, 2022, 20(4): 594-597. doi: 10.16766/j.cnki.issn.1674-4152.002408

Citation:

XU Chao-hui, ZHOU Le, JIANG Sheng-hua, XU Bao-cai, SHEN Zhong. Efficacy of the treatment with ultrasonic debridement combined with RhEGF in patients with perianal abscess infection[J]. Chinese Journal of General Practice, 2022, 20(4): 594-597. doi: 10.16766/j.cnki.issn.1674-4152.002408

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Efficacy of the treatment with ultrasonic debridement combined with RhEGF in patients with perianal abscess infection

doi: 10.16766/j.cnki.issn.1674-4152.002408

1.
Department of Anorectal Medicine, Quzhou Hospital of Traditional Chinese Medicine, Quzhou, Zhejiang 324002, China

Funds:

LGF20H030002

Received Date: 2021-10-15
Available Online: 2022-08-20

Abstract

Abstract

Objective To explore the efficacy of the treatment with ultrasonic debridement combined with recombinant human epidermal growth factor (RhEGF) in perianal abscess infection. Methods A total of 112 patients with perianal abscess infection admitted to Quzhou Hospital of Traditional Chinese Medicine, Zhejiang Province from Feb. 2019 to Feb. 2021 were selected and divided into ultrasound group (n=37), RhEGF group (n=37) and observation group (n=38) according to different treatment methods. Three group were given conventional antibiotics, the ultrasound group was treated with ultrasonic debridement, the RhEGF group was treated with RhEGF, and the observation group was treated with ultrasonic debridement combined with RhEGF. The clinical index level, pain degree, wound bacterial clearance rate and microcirculation index level were compared of three groups. Results The wound healing time and hospital stay in the observation group [(15.49±2.18) d, (15.53±2.06) d] were lower than those in the ultrasound group [(18.06±2.01) d, (18.52±1.73) d] and RhEGF group [(17.84±1.93) d, (17.98±1.85) d, F=18.291, 26.852, all P < 0.001]. The visual analogue scale score of 3 groups after treatment 1 d was lower than that before treatment (all P < 0.05), and the observation group was lower than that in the ultrasound group and RhEGF group (F=30.093, P < 0.001). The wound bacterial clearance rate of 3 groups after treatment 3 d was higher than that in after treatment 1 d (all P < 0.05), and the wound bacterial clearance rate after treatment 1 d and 3 d in the observation group were higher than those in the ultrasound group and RhEGF group (F=22.183, 31.650, all P < 0.001). The wound blood flow, percutaneous partial oxygen pressure and the level of serum epidermal growth factor of 3 groups after treatment 1 d were higher than those before treatment (all P < 0.05), and the observation group were higher than those in the ultrasound group and RhEGF group (F=4.406, 20.210, 51.552, the P value were 0.015, < 0.001, < 0.001, respectively). Conclusion Ultrasonic debridement combined with RhEGF is effective in the treatment of perianal abscess infection, which is helpful to the early recovery of patients.
- Ultrasonic debridement,
- Recombinant human epidermal growth factor,
- Perianal abscess infection,
- Wound healing,
- Microcirculation

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References

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Efficacy of the treatment with ultrasonic debridement combined with RhEGF in patients with perianal abscess infection

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Efficacy of the treatment with ultrasonic debridement combined with RhEGF in patients with perianal abscess infection

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