Volume 20 Issue 4
Apr.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 611-614
ZHENG Qun-yan, WU Qing-hua, JI Li-ting, ZHAN Lin-sen, DONG Gui-ling. Effect of goal-directed fluid therapy on short-term recovery of patients undergoing laparoscopic radical resection of rectal cancer[J]. Chinese Journal of General Practice, 2022, 20(4): 611-614. doi: 10.16766/j.cnki.issn.1674-4152.002412
Citation: ZHENG Qun-yan, WU Qing-hua, JI Li-ting, ZHAN Lin-sen, DONG Gui-ling. Effect of goal-directed fluid therapy on short-term recovery of patients undergoing laparoscopic radical resection of rectal cancer[J]. Chinese Journal of General Practice, 2022, 20(4): 611-614. doi: 10.16766/j.cnki.issn.1674-4152.002412
shu

Effect of goal-directed fluid therapy on short-term recovery of patients undergoing laparoscopic radical resection of rectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.002412

  • Department of Anesthesiology, Quzhou Hospital Affiliated to Wenzhou Medical University (Quzhou People's Hospital), Quzhou, Zhejiang 324000, China

Funds:

 2019RC306

  • Received Date: 2021-09-17
    Available Online: 2022-08-20
    Abstract
  •   Objective  To analyse the short-term efficacy of goal-directed fluid therapy in patients undergoing laparoscopic radical resection of rectal cancer.  Methods  Eighty-four patients undergoing laparoscopic radical resection of rectal cancer in Quzhou People's Hospital from June 2019 to January 2021 were randomly divided into the control group (42 cases) and observation group (42 cases). The control group was given routine infusion, and the observation group was treated with goal-directed fluid therapy. The therapeutic effects of the two groups were compared.  Results  The intraoperative urine volume, the amount of lens solution, the amount of colloid solution and the total amount of fluid in the observation group [(367.19±113.80) mL, (1 307.14±332.68) mL, (869.48±245.13) mL, (2 368.50±515.34) mL] were lower than those in the control group [(489.80±145.28) mL, (1 535.62±408.69) mL, (1 060.54±276.39) mL, (2 876.80±664.16) mL], t=4.306, 2.810, 3.352, 3.919, all P < 0.05. The results of repeated measurement analysis of variance showed significant differences in mean arterial pressure, heart rate and regional cerebral oxygen saturation between the two groups (all P < 0.05). After operation, the CD4+ and CD4+/CD8+ levels in the observation group were higher than those in the control group, and CD8+ level was lower than that in the control group (all P < 0.05). The extubation time, first anal exhaust time, defecation time, half fluid feeding time and hospital stay in the observation group were shorter than those in the control group (all P < 0.05).  Conclusion  Goal-directed fluid therapy can effectively reduce the amount of fluid in and out of patients undergoing laparoscopic radical resection of rectal cancer, maintain the stability of hemodynamic indexes and have little impact on immune function.

     

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