Volume 20 Issue 4
Apr.  2022
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 626-629
JIN Hai-yan, ZHAN Lu, XU Bin-bin, TIAN Pu-ren. Efficacy and serological study of self-designed influenza formula in treating influenza B in children[J]. Chinese Journal of General Practice, 2022, 20(4): 626-629. doi: 10.16766/j.cnki.issn.1674-4152.002416
Citation: JIN Hai-yan, ZHAN Lu, XU Bin-bin, TIAN Pu-ren. Efficacy and serological study of self-designed influenza formula in treating influenza B in children[J]. Chinese Journal of General Practice, 2022, 20(4): 626-629. doi: 10.16766/j.cnki.issn.1674-4152.002416
shu

Efficacy and serological study of self-designed influenza formula in treating influenza B in children

doi: 10.16766/j.cnki.issn.1674-4152.002416
  • 1.

    Department of Pediatric, Zhejiang Integrated Traditional and Western Medicine Hospital, Hangzhou, Zhejiang 310003, China

Funds:

 20192B091

  • Received Date: 2021-04-25
    Available Online: 2022-08-20
    Abstract
  •   Objective  To observe the clinical efficacy of self-made influenza formula in the treatment of influenza B in children and its effect on serological Interleukin 6 (IL-6) and Interferon-γ (IFN-γ).  Methods  Total 60 in the standard cases of children with influenza B were selected from the Pediatric Outpatient of Zhejiang Integrated Traditional and Western Medicine Hospital from January 2019 to February 2020. They were equally divided into observation and control groups according to the random-number table method, 30 cases in each group. Both groups supported symptomatic treatment. At the same time, the observation group was given oral self-made influenza formula and the control group was given oral oseltamivir for 5 days. The serum IL-6 and IFN- γ between the two groups and before and after treatment were recorded and compared.  Results  After 5 days of treatment, 2 cases of leakage were found in the observation group, and 1 case of leakage was found in the control group. The total effective rate of the observation group was 96.4%, higher than the 72.4% in the control group (P < 0.05). Before treatment, no difference in serum IL-6 and IFN-γ levels were found between the two groups, and the differences in IL-6 and IFN-γ before and after treatment were statistically significant (all P < 0.05). After treatment, the IL-6 level in the observation group was 0.53(0.36, 0.66) ng/L, which was lower than that in the control group [0.69(0.46, 1.37) ng/L], and the IFN-γ level in the observation group was 3.47(1.96, 5.90) ng/L, which was lower than that in the control group [5.07(2.38, 13.12) ng/L], with statistically significant differences (all P < 0.05).  Conclusion  Self-designed influenza can effectively treat influenza B in children, improve clinical symptoms, and reduce serum levels of IL-6 and IFN-γ. We speculate that its mechanism may play a role by reducing the levels of IL-6 and IFN-γ inflammatory factors.

     

    • FullText(HTML)
  • loading
    • References(16)
  • [1]
    付小康, 李全瑞. 2018—2019跨年期间流感样病例病原监测12 369例分析[J]. 中国临床医生杂志, 2019, 47(11): 1361-1363. doi: 10.3969/j.issn.2095-8552.2019.11.033

    FU X K, LI Q R. Analysis of 12 369 cases of influenza-like disease pathogen surveillance during 2018-2019[J]. Chinese journal of clinician, 2019, 47(11): 1361-1363. doi: 10.3969/j.issn.2095-8552.2019.11.033
    [2]
    付惠玲, 韩长青, 焦书真, 等. 2017年冬季本院甲乙型流感患儿的临床特点[J]. 临床医学研究与实践, 2019, 4(8): 82-85. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS201908032.htm

    FU H L, HAN C Q, JIAO S Z, et al. Clinical characteristics of children with influenza A and B in our hospital in winter of 2017[J]. Clinical medical research and practice, 2019, 4(8): 82-85. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS201908032.htm
    [3]
    中华人民共和国卫生健康委员会. 流行性感冒诊疗方案(2018年版修订版)[J]. 传染病信息, 2018, 31(6): 500-504. doi: 10.3969/j.issn.1007-8134.2018.06.002

    Health Commission of the People ' s Republic of China. Protocol for diagnosis and treatment of influenza(2018 revised version)[J]. Infectious Disease Information, 2018, 31(6): 500-504. doi: 10.3969/j.issn.1007-8134.2018.06.002
    [4]
    KOUTSAKOS M, NGUYEN T H, BARCLAY W S, et al. Knowns and unknowns of influenza B viruses[J]. Future Microbiol, 2016, 11(1): 119-135. doi: 10.2217/fmb.15.120
    [5]
    WAN S W, WU-HSIEH B A, LIN Y S, et al. The monocyte-macrophage-mast cell axis in dengue pathogenesis[J]. J Biomed Sci, 2018, 25(1): 77-87. doi: 10.1186/s12929-018-0482-9
    [6]
    于卓男, 林树鹏, 顾立刚, 等. 川芎嗪对甲型流感病毒H1N1诱导炎性细胞因子分泌作用的研究[J]. 中华中医药杂志, 2017, 32(6): 2680-2683. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201706095.htm

    YU Z N, LIN S P, GU L G, et al. Research of ligustrazine on influenza virus H1Nl-induced the secretion of inflammatory cytokines[J]. Chinese journal of traditional Chinese medicine, 2017, 32(6): 2680-2683. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201706095.htm
    [7]
    LIU B, BAO L, WANG L, et al. Anti-IFN-γ therapy alleviates acute lung injury induced by severe influenza A (H1N1) pdm09 infection in mice[J]. J Microbiol Immunol Infect, 2021, 54(3): 396-403. doi: 10.1016/j.jmii.2019.07.009
    [8]
    孙文英, 李莎莎, 闫一兵. 热性惊厥患儿血清白细胞介素-6及10水平变化[J]. 中华实用诊断与治疗杂志, 2016, 30(7): 699-700. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD201607026.htm

    SUN W Y, LI S S, YAN Y B. Changes of serum interleukin-6 and interleukin-10 in children with febrile seizures[J]. Chin J prin - diagnosis & therapy, 2016, 30(7): 699-700. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD201607026.htm
    [9]
    BETAKOVA T, KOSTRABOVA A, LACHOVA V, et al. Cytokines induced during influenza virus infection[J]. Curr Pharm Des, 2017, 23(18): 2616-2622.
    [10]
    陈刚, 陈红卫, 潘砚鹏, 等. 急性A型主动脉夹层并发肺损伤患者血清CRP、IL-6水平分析[J]. 中国现代医药杂志, 2020, 22(7): 54-56. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHTY202007023.htm

    CHEN G, CHEN H W, PAN Y P, et al. Serum levels of CRP and IL-6 in patients with acute type A aortic dissection complicated with lung injury[J]. Chinese journal of contemporary medicine, 2020, 22(7): 54-56. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHTY202007023.htm
    [11]
    樊江平, 刘成, 姜彩肖. IL-1β、IL-6、IFN-γ在甲型H1N1流感病毒性肺炎患者血清中的表达及其与疾病预后的相关性分析[J]. 临床肺科杂志, 2020, 25(6): 816-819, 901. doi: 10.3969/j.issn.1009-6663.2020.06.002

    FAN J P, LIU C, JIANG C X. Expressions of IL-1β, IL-6 and IFN-γin the serum of patients with influenza A H1N1 influenza virus pneu-monia and their correlation with disease prognosis[J]. Journal of clinical pulmonol, 2020, 25(6): 816-819, 901. doi: 10.3969/j.issn.1009-6663.2020.06.002
    [12]
    王勇, 王艺霏, 马骥, 等. 连花清瘟胶囊联合奥司他韦治疗儿童流感病毒感染疗效及对NO、IFN-γ、IL-17表达水平的影响[J]. 中华中医药学刊, 2020, 38(1): 214-216. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202001053.htm

    WANG Y, WANG Y F, MA J, et al. Efficacy of lianhua qingwen capsule combined with oseltamivir in treatment of influenza virus infection in children and its effect on the expression of NO, IFN-γand IL-17[J]. Chinese journal of traditional Chinese medicine, 2020, 38(1): 214-216. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202001053.htm
    [13]
    杨金亮, 刘畅, 齐文升. 流行性感冒的中医预防研究[J]. 中医学报, 2018, 33(9): 1679-1681. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZK201809020.htm

    YANG J L, LIU C, QI W S. Study on prevention of influenza with traditional Chinese Medicine[J]. Journal of traditional Chinese medicine, 2018, 33(9): 1679-1681. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZK201809020.htm
    [14]
    吕小琴, 李敏, 刘清泉. 流行性感冒不同病原的中医病证研究[J]. 中国中医急症, 2020, 29(1): 61-64. doi: 10.3969/j.issn.1004-745X.2020.01.016

    LYU X Q, LI M, LIU Q Q. Study on TCM syndrome of different etiology of influenza[J]. Chinese journal of TCM emergency, 2020, 29(1): 61-64. doi: 10.3969/j.issn.1004-745X.2020.01.016
    [15]
    YANG L, CHEN J, LU H, et al. Pueraria lobata for diabetes mellitus: Past, present and future[J]. Am J Chinese Med, 2019, 47(7): 1419-1444. doi: 10.1142/S0192415X19500733
    [16]
    姚玉乔, 高映, 彭财英, 等. 竹叶柴胡化学成分及药理活性的研究进展[J]. 安徽医药, 2019, 23(10): 1913-1916. doi: 10.3969/j.issn.1009-6469.2019.10.002

    YAO Y Q, GAO Y, PENG C Y, et al. Progress in studies on chemical constituents and pharmacological effects of Bupleurum marginatum[J]. Anhui medicine, 2019, 23(10): 1913-1916. doi: 10.3969/j.issn.1009-6469.2019.10.002
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (207) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return