Volume 20 Issue 4
Apr.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 630-634
JIN Wen-ran, ZHU Hai-juan, CHEN Hong-bo, LI Xiao-peng, WANG Sheng-you. The effect of nalbuphine combined with dexmedetomidine multimodal analgesia on postoperative analgesia for patients with repeat cesarean section[J]. Chinese Journal of General Practice, 2022, 20(4): 630-634. doi: 10.16766/j.cnki.issn.1674-4152.002417
Citation: JIN Wen-ran, ZHU Hai-juan, CHEN Hong-bo, LI Xiao-peng, WANG Sheng-you. The effect of nalbuphine combined with dexmedetomidine multimodal analgesia on postoperative analgesia for patients with repeat cesarean section[J]. Chinese Journal of General Practice, 2022, 20(4): 630-634. doi: 10.16766/j.cnki.issn.1674-4152.002417
shu

The effect of nalbuphine combined with dexmedetomidine multimodal analgesia on postoperative analgesia for patients with repeat cesarean section

doi: 10.16766/j.cnki.issn.1674-4152.002417

  • Department of Anaesthesiology, Hefei Women and Child Health Care Hospital, Hefei, Anhui 230601, China

Funds:

 201707d08050003

 hwk2017zd003

  • Received Date: 2021-04-14
    Available Online: 2022-08-20
    Abstract
  •   Objective  To observe the effect of dexmedetomidine plus ropivacaine in bilateral transverse abdominal plane block (TAPB) combined with patient-controlled intravenous analgesia (PCIA) in patients with low-dose naborphine on uterine contraction pain after cesarean section of scarred uterus.  Methods  From April to August 2019, 60 pregnant women who underwent cesarean section of scar uterus under spinal anesthesia in Hefei Maternal and Child Health Hospital were randomly divided into two groups: naborphine conventional dose group (NC group), naborphine low dose combined with ropivacaine and dexmedetomidine TAPB group (NDT group), with 30 cases in each group. The group of NDT received bilateral TAPB under ultrasound guidance after cesarean section, 30 mL of ropivacaine and dexmedetomidine mixture was injected into each side. Visual analog score (VAS), sleep time, incidence of adverse reactions, time of getting out of bed for the first time and satisfaction with analgesia were recorded in the two groups.  Results  The VAS scores of uterine contraction pain at 6, 12, 24, 36 and 48 hours after operation in NDT group [2.0 (1.0, 3.0), 3.0 (2.0, 3.0), 2.0 (2.0, 3.0), 2.0 (2.0, 2.0), 2.0 (1.0, 2.0) vs. 4.0 (3.0, 5.0), 4.0 (4.0, 5.0), 4.0(3.0, 5.0), 3.0 (2.8, 4.0), 2.0 (2.0, 3.0), all P < 0.05]. The sleep time at 24 and 48 hours after operation in NDT group was significantly longer than that in NC group [5.0 (4.8, 6.0) h/d, 6.0 (6.0, 7.0) h/d vs. 8.0 (7.0, 8.0) h/d, 8.0 (7.0, 8.0) h/d, all P < 0.05]. In NDT group, the first time out of bed was significantly shortened, the incidence of postoperative nausea, vomiting and dizziness were significantly reduced, and the satisfaction of maternal analgesia was significantly increased.  Conclusion  Low dose nalbuphine PCIA combined with ropivacaine, dexmedetomidine and TAPB multimodal analgesia regimen for postoperative analgesia of scar uterus after cesarean section has satisfactory effect and less adverse reactions.

     

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