Volume 20 Issue 5
May  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(5): 740-744
CAO Gao-xiang, LI Yi-jie, SHI Yi, SONG Guo-lei, JIANG Cong-qiao. Expression of TACC3 and its relationship with epithelial mesenchymal transformation in gastric adenocarcinoma[J]. Chinese Journal of General Practice, 2022, 20(5): 740-744. doi: 10.16766/j.cnki.issn.1674-4152.002443
Citation: CAO Gao-xiang, LI Yi-jie, SHI Yi, SONG Guo-lei, JIANG Cong-qiao. Expression of TACC3 and its relationship with epithelial mesenchymal transformation in gastric adenocarcinoma[J]. Chinese Journal of General Practice, 2022, 20(5): 740-744. doi: 10.16766/j.cnki.issn.1674-4152.002443
shu

Expression of TACC3 and its relationship with epithelial mesenchymal transformation in gastric adenocarcinoma

doi: 10.16766/j.cnki.issn.1674-4152.002443
  • 1.

    Departments of Gastrointestinal Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2017A219

 2016H105

 gxbjZD2016070

  • Received Date: 2021-04-18
    Available Online: 2022-09-05
    Abstract
  •   Objective  To investigate the expression of transforming acidic coiled-coil protein-3 (TACC3) in gastric adenocarcinoma (GAC) and explore the relationship between the expressions of TACC3 and epithelial-mesenchymal transition (EMT) and the clinicopathological parameters of patients.  Methods  A total of 113 GAC specimens and corresponding matched normal tissue specimens filed in Departments of Pathology, the First Affiliated Hospital of Bengbu Medical College from October 2013 to October 2014 were analysed for TACC3, E-cadherin and vimentin protein expressions by immunohistochemical staining.  Results  The positive expression rates of TACC3, E-cadherin and vimentin in GAC specimens and normal gastric tissues were 67.3%, 45.1%, 50.4% and 17.7%, 69.9%, 27.4%, respectively. The difference was statistically significant. Kaplan-Meier survival analysis showed that the survival time of patients with positive expression of TACC3 and vimentin was lower than that of patients with negative expression, and the difference was statistically significant (all P < 0.001). Patients who had positive expression of E-cadherin had a significantly higher OST than those with negative expression (P < 0.001). Multivariate analysis demonstrated that the positive expression of TACC3 and vimentin and the negative expression of E-cadherin were independent prognostic factors for GAC (all P < 0.05). Spearman correlation coefficient analysis showed that the expressions of TACC3 and vimentin were positively related. The relationship between E-cadherin and TACC3 was negatively correlated. The relationship between E-cadherin and vimentin was negatively correlated (all P < 0.001).  Conclusion  High expression of TACC3 is found to be related to EMT and poor prognosis in GAC. TACC3 is expected to become a new target for GAC targeted therapy, and early detection of TACC3 expression can be used to evaluate the metastasis and prognosis of GAC patients.

     

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