Effect of cardiac sympathetic nerve on the heart of spontaneously hypertensive rats

YUAN Hang; CHU Wan-fei; XU Qiang

doi:10.16766/j.cnki.issn.1674-4152.002446

Volume 20 Issue 5

May 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(5): 752-755

YUAN Hang, CHU Wan-fei, XU Qiang. Effect of cardiac sympathetic nerve on the heart of spontaneously hypertensive rats[J]. Chinese Journal of General Practice, 2022, 20(5): 752-755. doi: 10.16766/j.cnki.issn.1674-4152.002446

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YUAN Hang, CHU Wan-fei, XU Qiang. Effect of cardiac sympathetic nerve on the heart of spontaneously hypertensive rats[J]. Chinese Journal of General Practice, 2022, 20(5): 752-755. doi: 10.16766/j.cnki.issn.1674-4152.002446

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Effect of cardiac sympathetic nerve on the heart of spontaneously hypertensive rats

doi: 10.16766/j.cnki.issn.1674-4152.002446

YUAN Hang^{1
,
,}
, CHU Wan-fei²
, XU Qiang³

1.
Department of Electrophysiology, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang 315000, China

Funds:

2016KYA011

Received Date: 2021-09-14
Available Online: 2022-09-05

Abstract

Abstract

Objective To investigate the effect of cardiac sympathetic nerve on the heart of spontaneously hypertensive rats. Methods Thirty spontaneously hypertensive male rats aged 6-7 weeks were selected and divided into the observation group and control group according to the random number table method, each with 15 rats. The rats in the observation group were treated with sympathetic ganglion resection, and the sympathetic ganglion in the neck of the rats in the control group was exposed. The heart rate, blood pressure, left ventricular diastole, end-systolic diameter, left ventricular ejection fraction (LVEF) and myocardial collagen tissue Ⅰ, myocardial collagen tissue Ⅲ, connective tissue growth factor and norepinephrine transporter mRNA expression levels were compared between the two groups of rats. Results The heart rate of the observation group was significantly lower than that of the control group [(374.48±17.46) times/min vs. (403.12±14.56) times/min, t=4.879, P < 0.05]; The left ventricular end-diastolic diameter and left ventricular end-systolic diameter of the observation group were significantly lower than those in the control group [(4.97±0.52) mm vs. (4.51±0.45) mm, (3.06±0.23) mm vs. (2.57±0.17) mm, t=2.591, 6.635, all P < 0.05], The LVEF of the observation group was significantly lower than that in the control group [(71.48±4.46)% vs. (80.12±3.56)%, t=5.864, P < 0.05]; The expression of NET mRNA in the observation group were significantly higher than that in the control group (1.507±0.054 vs. 1.424±0.046, t=4.532, P < 0.05), and the expression of myocardial collagen Ⅲ and CTGF mRNA was significantly lower than that in the control group (1.245±0.046 vs. 1.359±0.036, 1.434±0.095 vs. 1.541±0.012, t=7.559, 4.328, P < 0.05). Conclusion Cardiac sympathetic nerve can adjust the CTGF, NET, inhibit myocardial hypertrophy and myocardial fibrosis in spontaneously hypertensive rats.
- Spontaneous hypertension,
- Cardiac sympathetic nerve,
- Heart rate,
- Messenger RNA expression

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References(26)

References

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Effect of cardiac sympathetic nerve on the heart of spontaneously hypertensive rats

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Effect of cardiac sympathetic nerve on the heart of spontaneously hypertensive rats

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