Volume 20 Issue 5
May  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(5): 773-776
WANG Zhen-jun, PAN Sun-feng, FANG Gao-feng, LIU Liang, ZHU Min-da. Observation on the curative effect of replantation of autologous thick skin in the donor area of elderly medium-thickness skin[J]. Chinese Journal of General Practice, 2022, 20(5): 773-776. doi: 10.16766/j.cnki.issn.1674-4152.002451
Citation: WANG Zhen-jun, PAN Sun-feng, FANG Gao-feng, LIU Liang, ZHU Min-da. Observation on the curative effect of replantation of autologous thick skin in the donor area of elderly medium-thickness skin[J]. Chinese Journal of General Practice, 2022, 20(5): 773-776. doi: 10.16766/j.cnki.issn.1674-4152.002451
shu

Observation on the curative effect of replantation of autologous thick skin in the donor area of elderly medium-thickness skin

doi: 10.16766/j.cnki.issn.1674-4152.002451

  • Department of Burn Orthopaedics, Jiaxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Chinese Medicine, Jiaxing, Zhejiang 314001, China

Funds:

 2020PY075

 2019AY32017

  • Received Date: 2021-04-19
    Available Online: 2022-09-05
    Abstract
  •   Objective  To observe the therapeutic effect of autologous thick skin replantation in the donor area of medium-thickness skin in elderly patients and explore a new therapeutic method.  Methods  A total of 50 elderly patients with deep burns and scar contracture who were admitted to the Department of Burns and Orthopaedics of Jiaxing Hospital of Traditional Chinese Medicine from March 2019 to June 2020 and who met the inclusion criteria were selected and divided into the treatment group and the control group by random number table method, with 25 patients in each group. The anterolateral thigh was selected as the donor area in both groups, and medium-thickness skin slices (0.3-0.4 mm) were cut to repair burns, functional parts, scars and other wounds. In the treatment group, blade thick skin slices (0.12-0.15 mm) were cut beside the donor area of the medium-thickness skin slices, and the slices were perforated and transplanted into the donor area of the medium-thickness skin slices. The donor area of the control group was covered with Vaseline gauze and then bandaged under pressure. The healing time, Vancouver Scar Scale score and pruritus score of medium-thickness skin donor site were compared between the two groups.  Results  On the 7th day after operation, all the donor grafts in the treatment group survived, and the healing time of donor grafts in the treatment group [9.0(8.0, 12.0) d] was significantly shorter than that in the control group [21.0(20.5, 24.5) d], with statistical significance (P < 0.05). Three months after surgery, the Vancouver Scar Scale score in the treatment group [3.0(2.0, 3.5) points] was lower than that in the control group [10.0(9.0, 11.0) points], the difference was statistically significant (P < 0.05), and the pruritus score [1.0(1.0, 2.0) points] was lower than that in the control group [6.0(5.0, 7.0) points], and the difference was statistically significant all (P < 0.05). Six months after surgery, the Vancouver scar scale score in the donor area of the treatment group [1.0(0.5, 1.5) points] was lower than that of the control group [6.0(4.0, 8.5) points], the difference was statistically significant (P < 0.05), and the pruri- tus score [1.0(1.0, 1.0) points] was lower than that of the control group [2.0(1.0, 2.5) points], the difference was statistically significant (P < 0.05).  Conclusion  The use of autologous blade thick skin grafting medium-thickness skin donor area can significantly shorten the wound healing time, reduce the degree of scar hyperplasia and has a good clinical effect.

     

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    • References(20)
  • [1]
    江政英, 闵定宏, 郭光华. 老年烧伤创面处理的研究进展[J]. 中华损伤与修复杂志(电子版), 2017, 12(6): 467-469. doi: 10.3877/cma.j.issn.1673-9450.2017.06.013

    JIANG Z Y, MIN D H, GUO G H. Research progress in wound treatment of burns in the elderly[J]. Chinese Journal of Injury Repair and Wound Healing, 2017, 12(6): 467-469. doi: 10.3877/cma.j.issn.1673-9450.2017.06.013
    [2]
    黄跃生, 任家顺, 钱桂生, 等. 实用烧伤治疗学[M]. 郑州: 郑州大学出版社, 2013: 390-391.

    HUANG Y S, REN J S, QIAN G S, et al. Practical burn therapy[M]. Zhengzhou: Zhengzhou University Press, 2013: 390-391.
    [3]
    沈小鹏, 李东. 瘢痕防治及其研究进展[J]. 中华临床医师杂志(电子版), 2019, 13(6): 463-467. doi: 10.3877/cma.j.issn.1674-0785.2019.06.012

    SHEN X P, LI D. Progress in scar prevention and treatment[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(6): 463-467. doi: 10.3877/cma.j.issn.1674-0785.2019.06.012
    [4]
    黄涛, 何升东, 李先慧, 等. 326例烧伤患者瘢痕瘙痒情况的总结分析[J]. 西南国防医药, 2019, 29(7): 749-751. doi: 10.3969/j.issn.1004-0188.2019.07.009

    HUANG T, HE S D, LI X H, et al. Summary and analysis of scar pruritus in 326 burn patients[J]. Summary and analysis of scar pruritus in 326 burn patients, 2019, 29(7): 749-751. doi: 10.3969/j.issn.1004-0188.2019.07.009
    [5]
    刘继松, 宋德恒, 赵刚宏, 等. 新型生物敷料Ⅱ型在二度烧伤创面中的应用[J]. 中华全科医学, 2018, 16(5): 740-743. doi: 10.16766/j.cnki.issn.1674-4152.000201

    LIU J S, SONG D H, ZHANG G H, et al. Application of new biological dressing type Ⅱ in the second degree burn wounds[J]. Chinese general practice, 2018, 16(5): 740-743. doi: 10.16766/j.cnki.issn.1674-4152.000201
    [6]
    吕鑫, 李磊, 张正文, 等. 促进中厚皮片移植供皮区修复的研究进展[J]. 中国美容医学, 2017, 26(1): 133-136. https://www.cnki.com.cn/Article/CJFDTOTAL-MRYX201701048.htm

    LYU X, LI L, ZHANG Z W, et al. Advances in research restoration of donor skin in intermediate thickness skin graft[J]. Chinese Journal of Aesthetic Medicine, 2017, 26(1): 133-136. https://www.cnki.com.cn/Article/CJFDTOTAL-MRYX201701048.htm
    [7]
    苏洋, 李欣, 邓程霖, 等. 老年综合评估工具的研究进展[J]. 中国老年学杂志, 2019, 39(5): 1270-1273. doi: 10.3969/j.issn.1005-9202.2019.05.076

    SU Y, LI X, DENG C L, et al. Research progress of comprehensive geriatric assessment tool[J]. Chinese Journal of Gerontology, 2019, 39(5): 1270-1273. doi: 10.3969/j.issn.1005-9202.2019.05.076
    [8]
    中华医学会老年医学分会. 老年患者衰弱评估与干预中国专家共识[J]. 中华老年医学杂志, 2017, 36(3): 251-256.

    Geriatric Society of Chinese Medical Association. Chinese experts consensus on assessment and intervention for elderly patients with frailty[J]. Chinese experts consensus on assessment and intervention for elderly patients with frailty, 2017, 36(3): 251-256.
    [9]
    王丽, 丁晓红, 于水. 供皮区创面应用两种不同敷料的疗效对比[J]. 临床骨科杂志, 2017, 20(2): 248-250. doi: 10.3969/j.issn.1008-0287.2017.02.048

    WANG L, DING X H, YU S. Comparison effect of two kinds of wound dressing for skin donor sites[J]. Journal of Clinical Orthopaedics, 2017, 20(2): 248-250. doi: 10.3969/j.issn.1008-0287.2017.02.048
    [10]
    王书军, 温从吉, 于海洲. 皮耐克在大面积烧伤患者关节部位瘢痕挛缩修复中的应用[J]. 中国美容医学, 2017, 26(11): 19-21. https://www.cnki.com.cn/Article/CJFDTOTAL-MRYX201711009.htm

    WANG S J, WEN C J, YU H Z. Application of PELNAC in the treatment of joints'scar plastic reconstruction[J]. Chinese Journal of Aesthetic Medicine, 2017, 26(11): 19-21. https://www.cnki.com.cn/Article/CJFDTOTAL-MRYX201711009.htm
    [11]
    黄耿坡. 探究自体头皮移植修复烧伤创面的效果[J]. 中国现代药物应用, 2019, 13(11): 82-83. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY201911044.htm

    HUANG G P. To explore the effect of autologous scalp transplantation in repairing burn wounds[J]. Chinese Journal of Modern Drug Application, 2019, 13(11): 82-83. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY201911044.htm
    [12]
    孙星辰. 异种脱细胞真皮基质敷料与凡士林油纱在中厚皮片供区术后愈合的临床研究[D]. 蚌埠: 蚌埠医学院, 2018.

    SUN X C. Clinical study on postoperative healing of allogeneic acellular dermal matrix dressing and vaseline gauze in medium thickness skin patch donor site[D]. Bengbu: Bengbu Medical College, 2018.
    [13]
    文科, 马燕, 刘漪沦, 等. 聚酰胺纱布敷料在急慢性创面的临床应用[J]. 中华全科医学, 2018, 16(3): 380-382. doi: 10.16766/j.cnki.issn.1674-4152.000105

    WEN K, MA Y, LIU Y L. Clinical application of polyamide gauze dressing in acute and chronic wounds[J]. Chinese general practice, 2018, 16(3): 380-382. doi: 10.16766/j.cnki.issn.1674-4152.000105
    [14]
    赵刚宏, 李勇, 刘继松, 等. 脱细胞真皮基质敷料在烧伤创面治疗中的应用进展[J]. 中华损伤与修复杂志(电子版), 2019, 14(3): 228-230. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHSX201903013.htm

    ZHAO G H, LI Y, LIU J S, et al. Progress in the application of acellular dermal matrix dressing in the treatment of burn wounds[J]. Chinese Journal of Injury Repair and Wound Healing, 2019, 14(3): 228-230. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHSX201903013.htm
    [15]
    沈小鹏, 李东. 瘢痕防治及其研究进展[J]. 中华临床医师杂志(电子版), 2019, 13(6): 463-467. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYD201906012.htm

    SHEN X P, LI D. Progress in scar prevention and treatment[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(6): 463-467. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYD201906012.htm
    [16]
    林时秀, 郭冰玉, 回蔷, 等. 刺五加皂苷E对人增生性瘢痕成纤维细胞生长的影响及其机制[J]. 中华烧伤杂志, 2021, 37(3): 279-281.

    LIN S X, GUO Y B, HUI Q, et al. Effects and mechanism of eleutheroside E on the growth of human hypertrophic scar fibroblasts[J]. Chinese Journal of Burns, 2021, 37(3): 279-281.
    [17]
    林宇建, 韩兵, 麦钰仪, 等. 深度创伤后瘢痕发生发展机制及干细胞来源的外泌体治疗研究进展[J]. 广东药科大学学报, 2021, 37(1): 142-147. https://www.cnki.com.cn/Article/CJFDTOTAL-GDYX202101038.htm

    LIN Y J, HAN B, MAI Y Y, et al. Progress on the mechanism of scar formation and development after deep trauma and the treatment of exosomes derived from stem cells[J]. Journal of Guangdong Pharmaceutical University, 2021, 37(1): 142-147. https://www.cnki.com.cn/Article/CJFDTOTAL-GDYX202101038.htm
    [18]
    SHI K, WANG F Z, XIA J H, et al. Pirfenidone inhibits epidural scar fibroblast proliferation and differentiation by regulating TGF-beta 1-induced Smad-dependent and-independent pathways[J]. Am J Transl Res, 2019, 11(3): 1593-1604.
    [19]
    SU L L, ZHENG J P, WANG Y, et al. Emerging progress on the mechanism and technology in wound repair[J]. Biomed Pha, 2019, 117: 109191. DOI: 10.1016/j.biopha.2019.109191.
    [20]
    洪武, 李少峰, 林钰梅. 网状中厚皮联合封闭式负压引流治疗难愈性创面疗效观察[J]. 中国医药科学, 2020, 10(3): 294-296. https://www.cnki.com.cn/Article/CJFDTOTAL-GYKX202003085.htm

    HONG W, LI S F, LIN Y M. Efficacy observation of mesh intermediate split-thickness skin graft combined with closed vacuum sealing drainage in the treatment of refractory wounds[J]. China Medicine And Pharmacy, 2020, 10(3): 294-296. https://www.cnki.com.cn/Article/CJFDTOTAL-GYKX202003085.htm
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