Volume 20 Issue 5
May  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(5): 777-780
XUE Peng-cheng, LI Jing-jing, CHEN Kang-yu. Changes and significance of red blood cell distribution width, blood uric acid, D-Dimer and B-ype natriuretic peptide in acute coronary syndrome[J]. Chinese Journal of General Practice, 2022, 20(5): 777-780. doi: 10.16766/j.cnki.issn.1674-4152.002452
Citation: XUE Peng-cheng, LI Jing-jing, CHEN Kang-yu. Changes and significance of red blood cell distribution width, blood uric acid, D-Dimer and B-ype natriuretic peptide in acute coronary syndrome[J]. Chinese Journal of General Practice, 2022, 20(5): 777-780. doi: 10.16766/j.cnki.issn.1674-4152.002452
shu

Changes and significance of red blood cell distribution width, blood uric acid, D-Dimer and B-ype natriuretic peptide in acute coronary syndrome

doi: 10.16766/j.cnki.issn.1674-4152.002452
  • 1.

    Department of Cardiology, the Third People's Hospital of Bengbu, Bengbu, Anhui 233000, China

Funds:

 2016080802D113

  • Received Date: 2021-04-18
    Available Online: 2022-09-05
    Abstract
  •   Objective  To study the significance of red blood cell distribution width (RDW), blood uric acid (BUA), D-Dimer and B-type natriuretic peptide (BNP) levels in acute coronary syndrome (ACS).  Methods  Total 171 patients with ACS who underwent coronary angiography in the Third People's Hospital of Bengbu City from January 2017 to March 2019 were collected as experimental group, and 65 patients with no obvious abnormalities in coronary angiography or coronary CT during the same period were selected as controls group. The RDW, BUA, D-Dimer and BNP of the two groups were compared. The experimental group was divided into groups by Gensini score, and 4 indicators of each group were analyzed. The patients were grouped according to the adverse cardiovascular events (MACE) during hospitalization, and 4 indicators in each group were analyzed. Logistic regression was used to analyze the relationship between 4 indicators and ACS.  Results  The levels of RDW, BUA, D-Dimer and BNP in the experimental group were higher than those in the control group (all P < 0.01). Gensini scores were different in each group in RDW, D-Dimer and BNP (all P < 0.01). There were differences in 4 indicators in the MACE group (all P < 0.01). Logistic regression analysis showed that the 4 indicators were all related to ACS, the sensitivity were 0.468, 0.544, 0.655 and 0.404, the specificity were 0.738, 0.662, 0.708 and 0.754, and the area under the curve (AUC) were 0.610, 0.617, 0.670 and 0.584, respectively. The sensitivity of the combination factor composed of four indicators was 0.731, the specificity was 0.631, and the AUC was 0.714.  Conclusion  RDW, BUA, D-Dimer and BNP are related to the condition of ACS patients. The combined detection of 4 indicators has clinical significance in ACS.

     

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