Volume 20 Issue 5
May  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(5): 801-804
JIANG Mao-ying, WANG Zun-hui, CHEN Dong, HUANG Hong-yu, ZHU Ping. Expression of miRNA-107 in peripheral blood of children with attention deficit hyperactivity disorder[J]. Chinese Journal of General Practice, 2022, 20(5): 801-804. doi: 10.16766/j.cnki.issn.1674-4152.002458
Citation: JIANG Mao-ying, WANG Zun-hui, CHEN Dong, HUANG Hong-yu, ZHU Ping. Expression of miRNA-107 in peripheral blood of children with attention deficit hyperactivity disorder[J]. Chinese Journal of General Practice, 2022, 20(5): 801-804. doi: 10.16766/j.cnki.issn.1674-4152.002458
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Expression of miRNA-107 in peripheral blood of children with attention deficit hyperactivity disorder

doi: 10.16766/j.cnki.issn.1674-4152.002458
  • 1.

    Child Health Care Department of Hangzhou Children's Hospital, Hangzhou, Zhejiang 310014, China

Funds:

 2017KY558

  • Received Date: 2021-05-10
    Available Online: 2022-09-05
    Abstract
  •   Objective  To measure the expression levels of miRNA-107 and miR-34c-3p in children with attention-deficit hyperactivity disorder (ADHD).  Methods  From January 2018 to September 2019, 37 children were admitted to the Developmental Behaviour Clinic of Children's Health Care in Hangzhou Children's Hospital and were set as the ADHD group. Seventy-four healthy children in our hospital were set as the healthy control group. The relative expression levels of miRNA-107 and miR-34c-3p in peripheral blood were detected by quantitative reverse transcription-polymerase chain reaction. The sensitivity and specificity of miRNA-107 in diagnosing ADHD were analysed according to the receiver operating characteristic (ROC) curve. The correlation between miRNA-107 expression and ADHD core symptoms was analysed.  Results  The relative expression of miRNA-107 in peripheral circulation was significantly lower in the ADHD group than in the control group (4.06±1.57 vs. 4.62±1.30, t=1.994, P=0.049), whereas miR-34c-3p showed no significant difference. The AUC of miRNA-107 was 0.609, the sensitivity was 97.3% and the specificity was 67.6%. Correlation analysis showed that the expression level of miRNA-107 in ADHD girls was negatively correlated with the degree of attention deficit (r=-0.861, P < 0.05).  Conclusion  MiRNA-107 may be a potential biomarker of ADHD and has a certain diagnostic significance.

     

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  • [1]
    BAKER A S, FREEMAN M P. Management of attention deficit hyperactivity disorder during pregnancy[J]. Obstet Gynecol Clin North Am, 2018, 45(3): 495-509. doi: 10.1016/j.ogc.2018.04.010
    [2]
    李世明, 冯为, 方芳, 等. 中国儿童注意缺陷多动障碍患病率meta分析[J]. 中华流行病学杂志, 2018, 39(7): 993-998. doi: 10.3760/cma.j.issn.0254-6450.2018.07.024

    LI S M, FENG W, FANG F, et al. Prevalence of attention deficit and hyperactivity disorder in children in China: a systematic review and Meta-analysis[J]. Chinese Journal of Epidemiology, 2018, 39(7): 993-998. doi: 10.3760/cma.j.issn.0254-6450.2018.07.024
    [3]
    ADLER L A, FARAONE S V, SPENCER T J, et al. The structure of adult ADHD[J]. Int J Methods Psychiatr Res, 2017, 26(1): e1555. doi: 10.1002/mpr.1555
    [4]
    CAO T, ZHEN X C. Dysregulation of miRNA and its potential therapeutic application in schizophrenia[J]. CNS Neurosci Ther, 2018, 24(7): 586-597. doi: 10.1111/cns.12840
    [5]
    赵旭凡, 杨红菊. 微核糖核酸在非酒精性脂肪性肝病中的研究进展[J]. 中国基层医药, 2019, 26(7): 893-896.

    ZHAO X F, YANG H J. Research progress of miRNA in nonalcoholic fatty liver disease[J]. Chinese Journal of Primary Medicine and Pharmacy, 2019, 26(7): 893-896.
    [6]
    BATTLE D E. Diagnostic and statistical manual of mental disorders(DSM)[J]. Codas, 2013, 25(2): 191-192.
    [7]
    AL-KAFAJI G, SAID H M, ALMA M A, et al. Blood-based microRNAs as diagnostic biomarkers to discriminate localized prostate cancer from benign prostatic hyperplasia and allow cancer-risk stratification[J]. Oncol Lett, 2018, 16(1): 1357-1365.
    [8]
    PAUL S, REYES P R, GARRZA B S, et al. MicroRNAs and child neuropsychiatric disorders: A brief review[J]. Neurochem Res, 2020, 45(2): 232-240. doi: 10.1007/s11064-019-02917-y
    [9]
    ZADEHBAGHERI F, HOSSEINI E, BAGHERI-HOSSEINABADI Z, et al. Profiling of miRNAs in serum of children with attention-deficit hyperactivity disorder shows significant alterations[J]. J Psychiatr Res, 2019, 109(10): 185-192.
    [10]
    VASU M M, SUMITHA P S, RAHNA P, et al. MicroRNAs in autism spectrum disorders[J]. Curr Pharm Des, 2019, 25(41): 4368-4378.
    [11]
    HU Y, EHLI E A, BOOMSMA D I. MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research[J]. Autism Res, 2017, 10(7): 1184-1203. doi: 10.1002/aur.1789
    [12]
    MAES M, ANDERSON G, BETANCORT MEDINA S R, et al. Integrating autism spectrum disorder pathophysiology: Mitochondria, vitamin A, CD38, oxytocin, serotonin and melatonergic alterations in the placenta and gut[J]. Curr Pharm Des, 2019, 25(41): 4405-4420.
    [13]
    WOHLFARTH C, SCHMITTECKERT S, HARTLE J D, et al. Mir-16 and Mir-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome[J]. Sci Rep, 2017, 7(1): 14680. doi: 10.1038/s41598-017-13982-0
    [14]
    OSES M, MARGARETO SANCHEZ J, et al. Circulating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: A systematic review[J]. Nutrients, 2019, 11(12): 2890. doi: 10.3390/nu11122890
    [15]
    KANDEMIR H, ERDAL M E, SELEK S, et al. Evaluation of several micro RNA (miRNA) levels in children and adolescents with attention deficit hyperactivity disorder[J]. Neuroscience Letters, 2014, 580: 158-162. doi: 10.1016/j.neulet.2014.07.060
    [16]
    WU L H, CHENG W, YU M, et al. Nr3C1-Bhlhb2 Axis dysregulation is involved in the development of attention deficit hyperactivity[J]. Mol Neurobiol, 2017, 54(2): 1196-1212. doi: 10.1007/s12035-015-9679-z
    [17]
    DICKSON D A, PAULUS J K, MENSAH V, et al. Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress[J]. Transl Psychiatry, 2018, 8(1): 101. doi: 10.1038/s41398-018-0146-2
    [18]
    王海明, 王建华. 微小RNA与胆管癌关系的研究进展[J]. 癌症进展, 2020, 18(10): 989-992, 1018. https://www.cnki.com.cn/Article/CJFDTOTAL-AZJZ202010005.htm

    WANG H M, WANG J H. Research progress on the relationship between microrNA and cholangiocarcinoma[J]. Oncology Progress, 2020, 18(10): 989-992, 1018. https://www.cnki.com.cn/Article/CJFDTOTAL-AZJZ202010005.htm
    [19]
    LAMBEZ B, HARWOOD-GROSS A, GOLUMBIC E Z, et al. Non-pharmacological interventions for cognitive difficulties in ADHD: A systematic review and meta-analysis[J]. J Psychiatr Res, 2020, 12(10): 40-55.
    [20]
    WANG T, SHI F, JIN Y, et al. Abnormal changes of brain cortical anatomy and the association with plasma microRNA107 level in amnestic mild cognitive impairment[J]. Front Aging Neurosci, 2016, 18(8): 112.
    [21]
    WANG T, SHI F, JIN Y, et al. Abnormal changes of brain cortical anatomy and the association with plasma microRNA107 level in amnestic mild cognitive impairment[J]. Front Aging Neurosci, 2016, 8: 112. DOI: 10.3389/fnagi.2016.00112.
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