Expression of miRNA-107 in peripheral blood of children with attention deficit hyperactivity disorder

JIANG Mao-ying; WANG Zun-hui; CHEN Dong; HUANG Hong-yu; ZHU Ping

doi:10.16766/j.cnki.issn.1674-4152.002458

Volume 20 Issue 5

May 2022

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Chinese Journal of General Practice > 2022 > 20(5): 801-804

JIANG Mao-ying, WANG Zun-hui, CHEN Dong, HUANG Hong-yu, ZHU Ping. Expression of miRNA-107 in peripheral blood of children with attention deficit hyperactivity disorder[J]. Chinese Journal of General Practice, 2022, 20(5): 801-804. doi: 10.16766/j.cnki.issn.1674-4152.002458

Citation:

JIANG Mao-ying, WANG Zun-hui, CHEN Dong, HUANG Hong-yu, ZHU Ping. Expression of miRNA-107 in peripheral blood of children with attention deficit hyperactivity disorder[J]. Chinese Journal of General Practice, 2022, 20(5): 801-804. doi: 10.16766/j.cnki.issn.1674-4152.002458

Citation:

PDF( 408 KB)

Expression of miRNA-107 in peripheral blood of children with attention deficit hyperactivity disorder

doi: 10.16766/j.cnki.issn.1674-4152.002458

1.
Child Health Care Department of Hangzhou Children's Hospital, Hangzhou, Zhejiang 310014, China

Funds:

2017KY558

Received Date: 2021-05-10
Available Online: 2022-09-05

Abstract

Abstract

Objective To measure the expression levels of miRNA-107 and miR-34c-3p in children with attention-deficit hyperactivity disorder (ADHD). Methods From January 2018 to September 2019, 37 children were admitted to the Developmental Behaviour Clinic of Children's Health Care in Hangzhou Children's Hospital and were set as the ADHD group. Seventy-four healthy children in our hospital were set as the healthy control group. The relative expression levels of miRNA-107 and miR-34c-3p in peripheral blood were detected by quantitative reverse transcription-polymerase chain reaction. The sensitivity and specificity of miRNA-107 in diagnosing ADHD were analysed according to the receiver operating characteristic (ROC) curve. The correlation between miRNA-107 expression and ADHD core symptoms was analysed. Results The relative expression of miRNA-107 in peripheral circulation was significantly lower in the ADHD group than in the control group (4.06±1.57 vs. 4.62±1.30, t=1.994, P=0.049), whereas miR-34c-3p showed no significant difference. The AUC of miRNA-107 was 0.609, the sensitivity was 97.3% and the specificity was 67.6%. Correlation analysis showed that the expression level of miRNA-107 in ADHD girls was negatively correlated with the degree of attention deficit (r=-0.861, P < 0.05). Conclusion MiRNA-107 may be a potential biomarker of ADHD and has a certain diagnostic significance.
- Attention deficit hyperactivity disorder,
- MicroRNA-107,
- Diagnoses,
- Biomarker

FullText(HTML)

References(21)

References

[1]	BAKER A S, FREEMAN M P. Management of attention deficit hyperactivity disorder during pregnancy[J]. Obstet Gynecol Clin North Am, 2018, 45(3): 495-509. doi: 10.1016/j.ogc.2018.04.010
[2]	李世明, 冯为, 方芳, 等. 中国儿童注意缺陷多动障碍患病率meta分析[J]. 中华流行病学杂志, 2018, 39(7): 993-998. doi: 10.3760/cma.j.issn.0254-6450.2018.07.024 LI S M, FENG W, FANG F, et al. Prevalence of attention deficit and hyperactivity disorder in children in China: a systematic review and Meta-analysis[J]. Chinese Journal of Epidemiology, 2018, 39(7): 993-998. doi: 10.3760/cma.j.issn.0254-6450.2018.07.024
[3]	ADLER L A, FARAONE S V, SPENCER T J, et al. The structure of adult ADHD[J]. Int J Methods Psychiatr Res, 2017, 26(1): e1555. doi: 10.1002/mpr.1555
[4]	CAO T, ZHEN X C. Dysregulation of miRNA and its potential therapeutic application in schizophrenia[J]. CNS Neurosci Ther, 2018, 24(7): 586-597. doi: 10.1111/cns.12840
[5]	赵旭凡, 杨红菊. 微核糖核酸在非酒精性脂肪性肝病中的研究进展[J]. 中国基层医药, 2019, 26(7): 893-896. ZHAO X F, YANG H J. Research progress of miRNA in nonalcoholic fatty liver disease[J]. Chinese Journal of Primary Medicine and Pharmacy, 2019, 26(7): 893-896.
[6]	BATTLE D E. Diagnostic and statistical manual of mental disorders(DSM)[J]. Codas, 2013, 25(2): 191-192.
[7]	AL-KAFAJI G, SAID H M, ALMA M A, et al. Blood-based microRNAs as diagnostic biomarkers to discriminate localized prostate cancer from benign prostatic hyperplasia and allow cancer-risk stratification[J]. Oncol Lett, 2018, 16(1): 1357-1365.
[8]	PAUL S, REYES P R, GARRZA B S, et al. MicroRNAs and child neuropsychiatric disorders: A brief review[J]. Neurochem Res, 2020, 45(2): 232-240. doi: 10.1007/s11064-019-02917-y
[9]	ZADEHBAGHERI F, HOSSEINI E, BAGHERI-HOSSEINABADI Z, et al. Profiling of miRNAs in serum of children with attention-deficit hyperactivity disorder shows significant alterations[J]. J Psychiatr Res, 2019, 109(10): 185-192.
[10]	VASU M M, SUMITHA P S, RAHNA P, et al. MicroRNAs in autism spectrum disorders[J]. Curr Pharm Des, 2019, 25(41): 4368-4378.
[11]	HU Y, EHLI E A, BOOMSMA D I. MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research[J]. Autism Res, 2017, 10(7): 1184-1203. doi: 10.1002/aur.1789
[12]	MAES M, ANDERSON G, BETANCORT MEDINA S R, et al. Integrating autism spectrum disorder pathophysiology: Mitochondria, vitamin A, CD38, oxytocin, serotonin and melatonergic alterations in the placenta and gut[J]. Curr Pharm Des, 2019, 25(41): 4405-4420.
[13]	WOHLFARTH C, SCHMITTECKERT S, HARTLE J D, et al. Mir-16 and Mir-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome[J]. Sci Rep, 2017, 7(1): 14680. doi: 10.1038/s41598-017-13982-0
[14]	OSES M, MARGARETO SANCHEZ J, et al. Circulating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: A systematic review[J]. Nutrients, 2019, 11(12): 2890. doi: 10.3390/nu11122890
[15]	KANDEMIR H, ERDAL M E, SELEK S, et al. Evaluation of several micro RNA (miRNA) levels in children and adolescents with attention deficit hyperactivity disorder[J]. Neuroscience Letters, 2014, 580: 158-162. doi: 10.1016/j.neulet.2014.07.060
[16]	WU L H, CHENG W, YU M, et al. Nr3C1-Bhlhb2 Axis dysregulation is involved in the development of attention deficit hyperactivity[J]. Mol Neurobiol, 2017, 54(2): 1196-1212. doi: 10.1007/s12035-015-9679-z
[17]	DICKSON D A, PAULUS J K, MENSAH V, et al. Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress[J]. Transl Psychiatry, 2018, 8(1): 101. doi: 10.1038/s41398-018-0146-2
[18]	王海明, 王建华. 微小RNA与胆管癌关系的研究进展[J]. 癌症进展, 2020, 18(10): 989-992, 1018. https://www.cnki.com.cn/Article/CJFDTOTAL-AZJZ202010005.htm WANG H M, WANG J H. Research progress on the relationship between microrNA and cholangiocarcinoma[J]. Oncology Progress, 2020, 18(10): 989-992, 1018. https://www.cnki.com.cn/Article/CJFDTOTAL-AZJZ202010005.htm
[19]	LAMBEZ B, HARWOOD-GROSS A, GOLUMBIC E Z, et al. Non-pharmacological interventions for cognitive difficulties in ADHD: A systematic review and meta-analysis[J]. J Psychiatr Res, 2020, 12(10): 40-55.
[20]	WANG T, SHI F, JIN Y, et al. Abnormal changes of brain cortical anatomy and the association with plasma microRNA107 level in amnestic mild cognitive impairment[J]. Front Aging Neurosci, 2016, 18(8): 112.
[21]	WANG T, SHI F, JIN Y, et al. Abnormal changes of brain cortical anatomy and the association with plasma microRNA107 level in amnestic mild cognitive impairment[J]. Front Aging Neurosci, 2016, 8: 112. DOI: 10.3389/fnagi.2016.00112.

Relative Articles

[1]	LIU Yuecun, LIU Qingxia, LIU Qi. Correlation and diagnostic significance of serum LncRNA NEAT1 and SP1 with H-Y grade in patients with Parkinson's disease[J]. Chinese Journal of General Practice, 2024, 22(6): 983-986. doi: 10.16766/j.cnki.issn.1674-4152.003549
[2]	SUN Qiaozhi, CHEN Changying, LI Hong, ZHANG Jie, WANG Junxia, WANG Panpan, XU Haili. Parental experience in caring for children with attention deficit hyperactivity disorder: a qualitative study[J]. Chinese Journal of General Practice, 2024, 22(6): 995-999. doi: 10.16766/j.cnki.issn.1674-4152.003552
[3]	YU Hui-juan, XING Li-li, YANG Fan, LI Guang-ming. Low-dose contrast-enhanced ultrasound combined with serum microRNA-1469 level in the diagnosis of benign and malignant liver tumours[J]. Chinese Journal of General Practice, 2023, 21(1): 104-107. doi: 10.16766/j.cnki.issn.1674-4152.002823
[4]	ZHA Zheng-wei, GAN Hui-zhong, PENG Qiong, KONG De-run. Diagnostic value of endoscopic ultrasonography for submucosal tumors of digestive tract[J]. Chinese Journal of General Practice, 2022, 20(2): 290-293. doi: 10.16766/j.cnki.issn.1674-4152.002335
[5]	LI Yong, GUO Min, KANG Ying-ying. Research progress of microRNA in thyroid cancer[J]. Chinese Journal of General Practice, 2022, 20(2): 298-301, 351. doi: 10.16766/j.cnki.issn.1674-4152.002337
[6]	ZHOU Guo-ling, ZHANG Xun, LIAO Wen-jing, LIU Yan, YU Rong-rong. Characteristics of intestinal flora in children with ADHD and combined with obesity[J]. Chinese Journal of General Practice, 2021, 19(12): 2061-2064. doi: 10.16766/j.cnki.issn.1674-4152.002237
[7]	YANG Hao-yi, CHEN Juan, LIU Hong-jiao, REN Jie, MAO Kui, YI Hui-ming, SUN Jie. Diagnostic analysis of the isolated anterior mitral cleft by routine transthoracic echocardiography[J]. Chinese Journal of General Practice, 2020, 18(9): 1449-1451,1489. doi: 10.16766/j.cnki.issn.1674-4152.001530
[8]	CHEN Xing, CHEN Chong-chong, HUANG Zheng, ZHONG Liang-jun. The application of cone beam CT in the diagnosis of vertical root fracture with different depth of periodontal pocket[J]. Chinese Journal of General Practice, 2020, 18(5): 730-733. doi: 10.16766/j.cnki.issn.1674-4152.001341
[9]	CHEN Min, ZHANG Lei, HU Yao-fang, XU Qu, WANG Jing, YANG Lei, HONG Qin, CHI Xia, CUI Yan. Characteristics analysis of wechsler intelligence scale in 73 preschool children with attention deficit hyperactivity disorder[J]. Chinese Journal of General Practice, 2020, 18(7): 1147-1149,1164. doi: 10.16766/j.cnki.issn.1674-4152.001451
[10]	WANG Jin-yan, ZHONG Yue-jiao, CHEN Ling-xiang, LI Yun-tao. The diagnosis and treatment of carcinoma of unknown primary[J]. Chinese Journal of General Practice, 2018, 16(12): 2067-2071. doi: 10.16766/j.cnki.issn.1674-4152.000564
[11]	YE Liu-qing, DING Jin-wang, ZHANG Min, LUO Zhong-yao, ZHOU Guo-ming, FENG Wei-liang. Research progress of HOX transcript antisense RNA in clinical diagnosis and treatment of breast cancer[J]. Chinese Journal of General Practice, 2018, 16(2): 286-290. doi: 10.16766/j.cnki.issn.1674-4152.000080
[12]	GAO Guo-peng, YAN Shuang-qin, CAO Hui, GU Chun-li, XU Ye-qing, NI Ling-ling, TAO Hui-hui, SHAO Ting, TAO Fang-biao. Interaction of household passive smoking with pickiness on hyperactivity behavior among preschool children[J]. Chinese Journal of General Practice, 2018, 16(3): 427-430. doi: 10.16766/j.cnki.issn.1674-4152.000119
[13]	WU Bole, HU Xiayun. Role of corneal confocal microscopy in diagnosis and treatment of fungal keratitis[J]. Chinese Journal of General Practice, 2017, 15(8): 1301-1304. doi: 10.16766/j.cnki.issn.1674-4152.2017.08.008
[14]	WU Ying, XU Sheng-qian, PENG Li-ping, LIU Wen, QI Shan, XU Jian-hua. Value of MRI of hands in diagnosis of early rheumatoid arthritis and bone joint injury[J]. Chinese Journal of General Practice, 2017, 15(3): 415-417. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.015
[15]	LV Qun. A Meta-analysis of the diagnosis value of latex agglutination test for the pulmonary cryptococcosis[J]. Chinese Journal of General Practice, 2017, 15(3): 521-523. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.048
[16]	CHEN Xue-fang, XU Wen-fang, WANG Jian-hua. Expression of circulating miRNAs in active pulmonary tuberculosis and its prognostic value[J]. Chinese Journal of General Practice, 2017, 15(11): 1941-1943,1996. doi: 10.16766/j.cnki.issn.1674-4152.2017.11.036
[17]	Fulati·maimaiti, LIANG Liang, Miriguli·shayiti, ZHU Song-qing, ZHANG Jian, SHENG Wei-bin. The clinical features and diagnostic strategies of spinal inflammatory granuloma[J]. Chinese Journal of General Practice, 2016, 14(4): 552-554,568. doi: 10.16766/j.cnki.issn.1674-4152.2016.04.012
[18]	ZHANG Lei, LIU Xue-gang, LI Xiao-jun, LIU Ge, SONG Chao, GENG Yang. Diagnosis and surgical treatment for complex solitary fibrous tumor in the mediastinum[J]. Chinese Journal of General Practice, 2016, 14(7): 1086-1089. doi: 10.16766/j.cnki.issn.1674-4152.2016.07.008
[19]	LIANG Shu-zeng, CHENG Hui, ZHANG Xue-mei. Early diagnosis and surgical treatment of acute traumatic diaphragmatic rupture[J]. Chinese Journal of General Practice, 2016, 14(3): 394-396,403. doi: 10.16766/j.cnki.issn.1674-4152.2016.03.018

Supplements(0)

Cited By

Cited by

Periodical cited type(3)

1.	陈晓利，方拴锋，李会，叶蓓. 郑州市学龄期儿童注意缺陷多动障碍患病现状及影响因素分析. 新乡医学院学报. 2025(03): 197-201 .
2.	杜林军，马敬斌，张晓兰，陈丽芳，田巧焕. 注意缺陷多动障碍患儿血清NSE, S100β水平与社会功能的关系研究. 四川医学. 2024(05): 502-506 .
3.	丁凯景，李梅，刘艳，王少华，周国岭. miR-4763-3p在注意缺陷多动障碍儿童血清中的表达及临床意义. 中国妇幼保健. 2023(20): 3873-3876 .

Other cited types(0)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(4)

Get Citation

PDF

XML

Article Metrics

Article views (267) PDF downloads(3)

Expression of miRNA-107 in peripheral blood of children with attention deficit hyperactivity disorder

doi: 10.16766/j.cnki.issn.1674-4152.002458