Volume 20 Issue 5
May  2022
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(5): 805-807
SHEN Ren, YANG Shan-pu, WU Yue-chao, ZHOU Yan, ZHANG Lin-tao. Expression of miRNA-155 in children with recurrent wheezing and its relationship with Th1/Th2 cell balance[J]. Chinese Journal of General Practice, 2022, 20(5): 805-807. doi: 10.16766/j.cnki.issn.1674-4152.002459
Citation: SHEN Ren, YANG Shan-pu, WU Yue-chao, ZHOU Yan, ZHANG Lin-tao. Expression of miRNA-155 in children with recurrent wheezing and its relationship with Th1/Th2 cell balance[J]. Chinese Journal of General Practice, 2022, 20(5): 805-807. doi: 10.16766/j.cnki.issn.1674-4152.002459
shu

Expression of miRNA-155 in children with recurrent wheezing and its relationship with Th1/Th2 cell balance

doi: 10.16766/j.cnki.issn.1674-4152.002459

  • Department of Pediatrics, Yuhuan People's Hospital of Zhejiang Province, Yuhuan, Zhejiang 317600, China

Funds:

 2019KY795

  • Received Date: 2021-05-10
    Available Online: 2022-09-05
    Abstract
  •   Objective  To analyse the expression of miRNA-155 in children with recurrent wheezing and to explore the possible relationship between miRNA-155 and wheezing and the balance of Th1/Th2 cells.  Methods  Forty cases of children with recurrent wheezing in Yuhuan People's Hospital from January 2019 to October 2020 were selected as observation group, and 40 cases of healthy children in our hospital at the same time were selected as control group. The levels of miRNA-155, IFN-γ and IL-4 in the peripheral blood of the two groups were detected.  Results  The expression of miRNA-155 in the observation group was 5.24(3.42, 7.45), and that in the control group was 6.52(4.51, 12.88). The expression of miRNA-155 in the observation group was significantly lower than that in the control group (P < 0.05). The IFN-γ/IL-4 value of the observation group was 0.73±0.09, and that of the control group was 0.82±0.10, and the difference was statistically significant (P < 0.05). The expression of miRNA-155 was negatively correlated with the number of wheezing in the observation group (r=-0.557, P < 0.05). No correlation was observed between the expression of miRNA-155 and IFN-γ/IL-4 value in the observation group (r=0.223, P>0.05).  Conclusion  The expression of miRNA-155 may be negatively correlated with the occurrence of wheezing in children, and the decreased expression of miRNA-155 may increase the risk of wheezing in children. Decreased IFN-γ-to-IL-4 ratio may increase the risk of wheezing in children, but there is no significant correlation between the expression of miRNA-155 and the balance of Th1/Th2 cells.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    王慧敏, 刘传合. 年幼儿童反复喘息发作的远期预后及影响因素[J]. 中华实用儿科临床杂志, 2019, 34(12): 957-959.

    WANG M H, LIU C H. Long-term prognosis and impact factors of recurrent wheezing in young children[J]. Chinese Journal of Applied Clinical Pediatrics, 2019, 34(12): 957-959.
    [2]
    林志雄, 林尧. 海口市学龄前儿童哮喘的影响因素分析[J]. 中国儿童保健杂志, 2018, 26(5): 569-571. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201805031.htm

    LIN Z X, LIN Y. Analysis of influencing factors of asthma among preschool children in Haikou[J]. Chinese Journal of Child Health Care, 2018, 26(5): 569-571. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201805031.htm
    [3]
    李男, 李云霞, 加慧, 等. miR-155与肺部疾病的研究进展[J]. 国际呼吸杂志, 2017, 37(8): 619-624. doi: 10.3760/cma.j.issn.1673-436X.2017.08.011

    LI N, LI Y X, JIA H, et al. Research advances on miR-155 in lung diseases[J]. International Journal of Respiration, 2017, 37(8): 619-624. doi: 10.3760/cma.j.issn.1673-436X.2017.08.011
    [4]
    CHEN H, XU X, CHENG S, et al. Small interfering RNA directed against microRNA-155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma[J]. Exp Ther Med, 2017, 14(5): 4391-4396.
    [5]
    OWORA A H, BECKER A B, CHAN-YEUNG M, et al. Wheeze trajectories are modifiable through early-life intervention and predict asthma in adolescence[J]. Pediatr Allergy Immunol, 2018, 29(6): 612-621. doi: 10.1111/pai.12922
    [6]
    王慧敏, 朱雯靓, 刘传合, 等. 年幼儿童反复喘息发作的转归及不同表型的危险因素[J]. 临床儿科杂志, 2018, 36(4): 272-276. doi: 10.3969/j.issn.1000-3606.2018.04.009

    WANG M H, ZHU W L, LIU C H, et al. The outcome of recurrent wheezing and the risk factors of its different phenotypes in young children[J]. Journal of Clinical Pediatrics, 2018, 36(4): 272-276. doi: 10.3969/j.issn.1000-3606.2018.04.009
    [7]
    SUN M, LU Q. MicroRNA regulation of airway smooth muscle function[J]. Biol Chem, 2016, 397(6): 507-511. doi: 10.1515/hsz-2015-0298
    [8]
    代香兰, 兀威, 冯梅. MicroRNA-155在支气管哮喘中的研究进展[J]. 国际呼吸杂志, 2018, 38(2): 118-121. doi: 10.3760/cma.j.issn.1673-436X.2018.02.008

    DAI L X, WU W, FENG M. Progress of microRNA-155 in bronchial asthma[J]. International Journal of Respiration, 2018, 38(2): 118-121. doi: 10.3760/cma.j.issn.1673-436X.2018.02.008
    [9]
    尚朋娟, 高涛. miR-21、miR-155在支气管哮喘患儿血清中的表达及与气道炎症的相关性分析[J]. 中国妇幼保健, 2019, 34(2): 434-437. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201902064.htm

    SHANG P J, GAO T. Expression of miR-21 and miR-155 in serum of children with bronchial asthma Analysis of correlation between airway inflammation and airway inflammation[J]. Maternal and Child Health Care of China, 2019, 34(2): 434-437. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201902064.htm
    [10]
    ELKASHEF S M M A E, AHMAD S E, SOLIMAN Y, et al. Role of microRNA-21 and microRNA-155 as biomarkers for bronchial asthma[J]. Innate Immun, 2021, 27(1): 61-69. doi: 10.1177/1753425920901563
    [11]
    KARAM R A, ABD ELRAHMAN D M. Differential expression of miR-155 and Let-7a in the plasma of childhood asthma: Potential biomarkers for diagnosis and severity[J]. Clin Biochem, 2019, 68: 30-36. doi: 10.1016/j.clinbiochem.2019.04.007
    [12]
    BLOMME E E, PROVOOST S, BAZZAN E, et al. Innate lymphoid cells in isocyanate-induced asthma: Role of microRNA-155[J]. Eur Respir J, 2020, 56(3): 1901289. doi: 10.1183/13993003.01289-2019
    [13]
    QIU Y Y, ZHANG Y W, QIAN X F, et al. miR-371, miR-138, miR-544, miR-145, and miR-214 could modulate Th1/Th2 balance in asthma through the combinatorial regulation of Runx3[J]. Am J Transl Res, 2017, 9(7): 3184-3199.
    [14]
    周好好, 黄翠萍. microRNA-155与支气管哮喘的研究进展[J]. 中国免疫学杂志, 2019, 35(14): 1791-1794. doi: 10.3969/j.issn.1000-484X.2019.14.026

    ZHOU H H, HUANG C P. Advances in research of microRNA-155 and bronchial asthma[J]. Chinese Journal of Immunology, 2019, 35(14): 1791-1794. doi: 10.3969/j.issn.1000-484X.2019.14.026
    [15]
    王卫平, 孙锟, 常立文. 儿科学[M]. 9版. 北京: 人民卫生出版社, 2018: 245-247.

    WANG W P, SUN K, CHANG L W. Pediatrics[M]. Version 9. Beijing: People's Medical Publishing House, 2018: 245-247.
    [16]
    陈阵, 王恩洁, 管敏昌. 哮喘患儿外周血淋巴细胞亚群和CD4+T细胞亚群的变化情况[J]. 中华全科医学, 2017, 15(5): 811-813. doi: 10.16766/j.cnki.issn.1674-4152.2017.05.025

    CHEN Z, WANG E J, GUAN M C. Changes of peripheral blood lymphocyte subsets and CD4 + T cell subsets in children with asthma[J]. Chinese general practice, 2017, 15(5): 811-813. doi: 10.16766/j.cnki.issn.1674-4152.2017.05.025
    [17]
    李雯, 赵伟伟, 葛建敏, 等. 咳嗽变异性哮喘患儿外周血miR-155、SOCS-1表达变化与Th1/Th2失衡的关系[J]. 山东医药, 2021, 61(4): 48-50. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY202104012.htm

    LI W, ZHAO W W, GE J M, et al. Relationship between the expression of miR-155, SOCS-1 and Th1/Th2 imbalance in peripheral blood of children with cough variant asthma[J]. Shandong Med J, 2021, 61(4): 48-50. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY202104012.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (254) PDF downloads(1) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return