Volume 20 Issue 5
May  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(5): 824-827
YAO Kou-yun, DU Dan-li, LI Xiang. Application of human cartilage glycoprotein 39 and alpha-fetoprotein combined ultrasound in prenatal diagnosis of implanted placenta previa[J]. Chinese Journal of General Practice, 2022, 20(5): 824-827. doi: 10.16766/j.cnki.issn.1674-4152.002464
Citation: YAO Kou-yun, DU Dan-li, LI Xiang. Application of human cartilage glycoprotein 39 and alpha-fetoprotein combined ultrasound in prenatal diagnosis of implanted placenta previa[J]. Chinese Journal of General Practice, 2022, 20(5): 824-827. doi: 10.16766/j.cnki.issn.1674-4152.002464
shu

Application of human cartilage glycoprotein 39 and alpha-fetoprotein combined ultrasound in prenatal diagnosis of implanted placenta previa

doi: 10.16766/j.cnki.issn.1674-4152.002464

  • Department of Gynecology and Obstetrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2008085QH407

  • Received Date: 2021-09-28
    Available Online: 2022-09-05
    Abstract
  •   Objective  To evaluate the value of human cartilage glycoprotein-39 (YKL-40) and alpha fetoprotein (AFP) combined with ultrasound in placenta previa implantation.  Methods  A total of 90 pregnant women with placenta previa who delivered in the First Affiliated Hospital of Bengbu Medical College from November 2020 to May 2021 were enrolled as the research group. According to the intraoperative and/or postoperative pathological results, they were divided into the implantation group (4 cases of penetrating type, 17 cases of implantation type and 29 cases of adhesion type), 50 cases of non-implantation group and 40 cases of non-implantation group. In addition, 40 normal pregnant women in the same period were collected as the control group, and all received YKL-40, AFP and ultrasound examination.  Results  The levels of YKL-40 and AFP in the non-implantable group and control group were lower than those in the implantable group (all P < 0.05). The levels of YKL-40 in the implantable group were lower than those in the implantable group, and those in implantable group were lower than those in the penetrating group (all P < 0.05). AFP in the implantable group and implantable group were lower than those in the penetrating group (all P < 0.05). ROC curve analysis showed that the optimal cut-off values of serum YKL-40 and AFP were 320.284 pg/mL and 277.895 μg/mL, respectively, and the areas under the curve were 0.780 and 0.812, respectively. The AUC (0.895), Yuden index (0.675), sensitivity (90.0%) and negative predictive value (85.3%) of combined diagnosis were higher than those of single tests.  Conclusion  Serum YKL-40 and AFP levels combined with ultrasound can improve the diagnostic efficiency of placenta previa.

     

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