Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 941-943
ZHU Wei, LU Ran, YU Chao-wen, NIE Zhong-lin, CHEN Shi-yuan, SONG Tao. Application value of D-dimer and fibrinogen combined with venous patency score in thrombolysis of deep venous thrombosis of lower extremities[J]. Chinese Journal of General Practice, 2022, 20(6): 941-943. doi: 10.16766/j.cnki.issn.1674-4152.002493
Citation: ZHU Wei, LU Ran, YU Chao-wen, NIE Zhong-lin, CHEN Shi-yuan, SONG Tao. Application value of D-dimer and fibrinogen combined with venous patency score in thrombolysis of deep venous thrombosis of lower extremities[J]. Chinese Journal of General Practice, 2022, 20(6): 941-943. doi: 10.16766/j.cnki.issn.1674-4152.002493
shu

Application value of D-dimer and fibrinogen combined with venous patency score in thrombolysis of deep venous thrombosis of lower extremities

doi: 10.16766/j.cnki.issn.1674-4152.002493

  • Department of Vascular Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0327

 Byycxz20049

  • Received Date: 2021-09-30
    Available Online: 2022-09-21
    Abstract
  •   Objective  To analyze the changes of D-dimer, fibrinogen and venous patency score during catheter-directed thrombolysis (CDT) in deep venous thrombosis of lower limbs, and to evaluate their clinical application value.  Methods  Thirty-seven patients diagnosed with acute lower extremity deep vein thrombosis at the First Affiliated Hospital of Bengbu Medical College from June 2019 to June 2021 were included as the research objects. All patients were treated with inferior vena cava filter surgery, anticoagulation and CDT. During the treatment, D-dimer and fibrinogen were measured and recorded 1 day before operation and twice a day after operation until 7 days after operation, and the venous patency scores were calculated 1 day before operation, 3 days after operation and 7 days after catheter thrombolysis.  Results  None of the 37 patients had pulmonary embolism symptoms such as dyspnoea, haemoptysis and chest pain during CDT. In this treatment group, there were 2 patients with popliteal puncture site bleeding, 1 patient with gingival bleeding, without special treatment, and no serious bleeding and other complications. In the process of CDT for deep vein thrombosis of lower limbs, the average value of D-dimer firstly increased during DVT thrombolytic process, and reached the highest level at 77.4 mg/L two days after the operation, and then gradually decreased to the normal level. The average value of fibrinogen generally showed a downward trend during DVT thrombolytic process. The venous patency score was (3.7±0.9) points 3 days after surgery, and (2.4±0.7) points 7 days after surgery, the difference was statistically significant (P < 0.05).  Conclusion  D-dimer can be used to monitor thrombolysis time and therapeutic effect, fibrinogen can be used to monitor thrombolysis stop and bleeding, and the change of venous patency score can be used as an indicator of thrombus clearance in the process of CDT in deep vein thrombosis of lower limbs.

     

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