Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 944-947
YAO Rui, JI Xiao-wei, ZHONG Lei, WANG Hai-li, XIE Bo. The predictive value of neutrophil-lymphocyte ratio in the prognosis of patients with cardiac arrest[J]. Chinese Journal of General Practice, 2022, 20(6): 944-947. doi: 10.16766/j.cnki.issn.1674-4152.002494
Citation: YAO Rui, JI Xiao-wei, ZHONG Lei, WANG Hai-li, XIE Bo. The predictive value of neutrophil-lymphocyte ratio in the prognosis of patients with cardiac arrest[J]. Chinese Journal of General Practice, 2022, 20(6): 944-947. doi: 10.16766/j.cnki.issn.1674-4152.002494
shu

The predictive value of neutrophil-lymphocyte ratio in the prognosis of patients with cardiac arrest

doi: 10.16766/j.cnki.issn.1674-4152.002494
  • 1.

    Department of Intensive Care Unit, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang 313000, China

Funds:

 LGD20H150001

  • Received Date: 2021-09-11
    Available Online: 2022-09-21
    Abstract
  •   Objective  To evaluate the use of neutrophil-lymphocyte ratio (NLR) upon admission to an intensive care unit (ICU) in predicting mortality amongst patients who suffered cardiac arrest (CA).  Methods  This study was a retrospective cohort study using the latest version of the Intensive Care Database (MIMIC-Ⅲ v1.4). Adult CA patients (≥ 18 years old) admitted to the ICU for the first time from June 2001 to October 2012 were analysed, and clinical data were extracted by relevant qualified personnel. The primary endpoints were as follows: ICU and 28-day all-cause mortality. NLR was divided into three groups in accordance with tertiles, defined by ranges of < 7.00, 7.00-13.60 and ≥ 13.60. The related clinical data of these patients were analysed based on those three groups. Survival analyses were carried out to analyse the ICU and 28-day cumulative survival rates in these groups by using the Kaplan-Meier curves and log-rank test. Meanwhile, the Cox proportional hazard models were used to identify independent predictors of 28-day all-cause mortality amongst CA patients.  Results  A total of 593 adult participants with CA were involved in our study. The ICU and 28-day all-cause mortality of CA patients were 34.74% and 46.37%, respectively. Except for the remaining indicators, the variables of NLR, SOFA score, buffer excess, white blood cells, platelets and 28-day all-cause mortality showed significant differences amongst these three groups (all P < 0.05). Kaplan-Meier analysis revealed that the difference in the cumulative survival rate of the 28 days was no significant (log-rank test, χ2=5.900, P=0.052). The univariate Cox proportional hazard model showed that an increased level of NLR (≥ 13.60) was a risk factor for 28-day all-cause mortality in CA patients. This result was still supported by the multivariate Cox proportional hazard models analysis, even after controlling for the confounders.  Conclusion  An elevated NLR (≥13.60) is associated with poor prognosis for CA patients, and it can be used as an independent predictor for risk of 28-day all-cause mortality. In conclusion, as a novel prognostic marker in CA patients, monitoring the changes in NLR have important clinical value in assessing the prognosis of these patients.

     

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