Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 948-951
DAI Si-yuan, JIANG Jie, HAN Rui, XU Jin-cheng. Expression and significance of heparanase, E-cadherin, and N-cadherin in oral squamous cell carcinoma[J]. Chinese Journal of General Practice, 2022, 20(6): 948-951. doi: 10.16766/j.cnki.issn.1674-4152.002495
Citation: DAI Si-yuan, JIANG Jie, HAN Rui, XU Jin-cheng. Expression and significance of heparanase, E-cadherin, and N-cadherin in oral squamous cell carcinoma[J]. Chinese Journal of General Practice, 2022, 20(6): 948-951. doi: 10.16766/j.cnki.issn.1674-4152.002495
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Expression and significance of heparanase, E-cadherin, and N-cadherin in oral squamous cell carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.002495
  • 1.

    Department of Stomatology, the Bengbu Third People's Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China

Funds:

 KJ2021ZD0088

  • Received Date: 2022-02-09
    Available Online: 2022-09-21
    Abstract
  •   Objective  To study the expression of heparanase (HPA), epithelial marker E-cadherin and interstitial marker N-cadherin in oral squamous cell carcinoma (OSCC), and to explore the relationship between the three proteins and the clinicopathological features of OSCC.  Methods  The protein levels of HPA, E-cadherin and N-cadherin were assessed in OSCC tissues from 46 patients and normal tissues from 15 controls by immunohistochemistry. χ2 test was used to analyze the expression of three proteins in OSCC, and to detect the relationship between them and the clinicopathological characteristics of OSCC. Then the independent influencing factors were screened by multivariate binary logistic regression analysis. At the same time, Spearman rank correlation analysis was used to analyze the relationship between the expression of the three proteins.  Results  The positive expression rate of HPA in OSCC was 73.9%, while it was negative in normal oral mucosal epithelium (P < 0.001). There were significant differences in the positive expression rates of E-cadherin (56.5% vs. 93.3%) and N-cadherin (47.8% vs. 13.3%) between OSCC and normal oral mucosal epithelial tissues (all P < 0.05). There was significant difference in the positive expression rate of HPA in patients with different clinical stages, degrees of differentiation and lymph node metastasis (P < 0.05). Logistic regression analysis showed that clinical stage, degree of differentiation and lymph node metastasis were related to the positive expression of HPA. HPA expression was negatively correlated with E-cadherin expression (r=-0.321, P < 0.05), but it was positively correlated with N-cadherin expression (r=0.371, P < 0.05).  Conclusion  HPA is highly expressed in OSCC, which is closely related to the clinical stage, degree of differentiation and lymph node metastasis. HPA is negatively correlated with E-cadherin, but positively correlated with N-cadherin. The potential mechanism is that HPA may regulate epithelial interstitial transformation (EMT) in OSCC. Therefore, the expression of HPA can promote the invasion and metastasis of OSCC, and this effect may be achieved by HPA inducing epithelial mesenchymal transformation in OSCC.

     

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