Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 967-969
YANG Qing-feng, WANG Hua-guan, HAN Liang, LEI Jia-cai, HUANG Hai-tao, YAN Shan-jun. Effect of indomethacin on helper T cells in peripheral blood after endoscopic retrograde cholangiopancreatography[J]. Chinese Journal of General Practice, 2022, 20(6): 967-969. doi: 10.16766/j.cnki.issn.1674-4152.002500
Citation: YANG Qing-feng, WANG Hua-guan, HAN Liang, LEI Jia-cai, HUANG Hai-tao, YAN Shan-jun. Effect of indomethacin on helper T cells in peripheral blood after endoscopic retrograde cholangiopancreatography[J]. Chinese Journal of General Practice, 2022, 20(6): 967-969. doi: 10.16766/j.cnki.issn.1674-4152.002500
shu

Effect of indomethacin on helper T cells in peripheral blood after endoscopic retrograde cholangiopancreatography

doi: 10.16766/j.cnki.issn.1674-4152.002500
  • 1.

    Department of Gastroenterology, Hangzhou Ninth People ' s Hospital, Hangzhou, Zhejiang 311225, China

Funds:

 2020KY704

 B20200616

  • Received Date: 2021-03-24
    Available Online: 2022-09-21
    Abstract
  •   Objective  To investigate the possible cytological mechanism of indomethacin suppository in the prevention of pancreatitis (PEP) after endoscopic retrograde cholangiopancreatography (ERCP).  Methods  Forty patients who were hospitalised in the Department of Gastroenterology of the First Affiliated Hospital of Bengbu Medical College from March 2017 to October 2017 and planned to undergo ERCP were randomly divided into the observation group and control group, with 20 cases in each group.The peripheral venous blood Treg, Th17 and Treg/Th17 values of the two groups were measured before and 12 h after ERCP.  Results  In the control group, the preoperative Treg, Th17 and Treg/Th17 values were 2.94(1.52, 3.71)%, 1.42(0.87, 4.47)% and 1.57(0.69, 2.88), and the postoperative values were 1.92(1.22, 3.25)%, 2.02(1.12, 4.93)% and 0.77(0.37, 1.75), respectively.There were significant differences in the preoperative and postoperative changes.In the observation group, the preoperative Treg, Th17 and Treg/Th17 values were 1.57(0.97, 2.37)%, 1.92(1.27, 3.05)% and 0.74(0.39, 2.28), and the postoperative values were 1.63(1.03, 1.86)%, 2.26(1.36, 3.65)% and 0.65(0.38, 1.64), respectively.There was no significant difference between the preoperative and postoperative changes.There was no significant difference in other indexes between the two groups except for the preoperative Treg difference (Z=-2.259, P=0.024).  Conclusion  The possible mechanism of indomethacin suppository in preventing PEP after ERCP is to maintain the immune balance of Treg and Th17 cells and control the early inflammatory response after ERCP.

     

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