Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 1007-1011
LEI Wei, LI Hui, MA Zhi-qiang. Diagnostic value of preoperative ultrasound combined with BRAF gene in lymph node staging in patients with papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2022, 20(6): 1007-1011. doi: 10.16766/j.cnki.issn.1674-4152.002511
Citation: LEI Wei, LI Hui, MA Zhi-qiang. Diagnostic value of preoperative ultrasound combined with BRAF gene in lymph node staging in patients with papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2022, 20(6): 1007-1011. doi: 10.16766/j.cnki.issn.1674-4152.002511
shu

Diagnostic value of preoperative ultrasound combined with BRAF gene in lymph node staging in patients with papillary thyroid carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.002511
  • 1.

    Department of Ultrasound Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henson of clinical characteristican 450052, China

Funds:

 LHGJ20200544

  • Received Date: 2021-05-13
    Available Online: 2022-09-21
    Abstract
  •   Objective  To investigate the difference in the preoperative diagnostic rate of papillary thyroid carcinoma (PTC) by using ultrasound combined with BRAF gene mutation detection, and to provide scientific and reliable imaging and molecular basis for the selection of surgical treatment and surgical method.  Methods  A total of 120 patients with PTC admitted to our hospital from January to October 2020 were retrospectively analysed.According to the American Joint Committee on Cancer thyroid cancer staging system standard, patients with PTC were divided into three groups: N0, N1a and N1b.All 120 patients underwent preoperative ultrasound examination and thyroidectomy, and the pathological diagnosis was the gold standard.PTC ultrasonography, gender, age, BRAF gene test results and Hashimoto's thyroiditis background were analysed between N0 and N1 groups and between N1b and non-N1b groups.Univariate and multivariate logistic regression analysis were used to compare the related factors that may affect PTC N staging.  Results  Amongst 120 PTC patients, 63 patients were pathologically diagnosed as N0 stage, 38 as N1a stage, 19 as N1b stage and 57 as N1 stage.Ultrasonic diagnosis showed that 57 cases were N0 stage, 45 cases were N1a stage, 18 cases were N1b stage, and 63 cases were N1 stage.Preoperative ultrasound assessment of N stage was consistent with pathological diagnosis, and the difference was statistically significant (Kappa=0.725, P < 0.05).There were significant differences in age, tumour diameter and BRAF gene mutation between N0 and N1 patients (all P < 0.05).There were significant differences between non-N1B stage and N1b stage patients in tumour diameter, multiple lesions and extracapsular invasion (all P < 0.05).Multivariate logistic regression analysis showed that age, tumour diameter and BRAF gene mutation were independent influencing factors for N0 stage and N1 stage (all P < 0.05), while tumour diameter>1 cm, multiple lesions and extracapsular invasion were independent risk factors for N1b stage (all P < 0.05).  Conclusion  Combined with ultrasound examination, age, tumour diameter, BRAF gene, multiple lesions and extracapsular invasion, clinical-related influencing indicators are correlated with N stage of PTC.Preoperative ultrasonography can be used to evaluate PTC N staging, which is helpful to assist clinical diagnosis and treatment.

     

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