Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 1019-1021
WANG Li-zhi, HUANG Ruo-fei, LYU Mei-yan, TIAN Yuan. Correlation analysis of serum glycosylated haemoglobin, interleukin-6 and cystatin C with GFR in elderly patients with diabetic nephropathy[J]. Chinese Journal of General Practice, 2022, 20(6): 1019-1021. doi: 10.16766/j.cnki.issn.1674-4152.002514
Citation: WANG Li-zhi, HUANG Ruo-fei, LYU Mei-yan, TIAN Yuan. Correlation analysis of serum glycosylated haemoglobin, interleukin-6 and cystatin C with GFR in elderly patients with diabetic nephropathy[J]. Chinese Journal of General Practice, 2022, 20(6): 1019-1021. doi: 10.16766/j.cnki.issn.1674-4152.002514
shu

Correlation analysis of serum glycosylated haemoglobin, interleukin-6 and cystatin C with GFR in elderly patients with diabetic nephropathy

doi: 10.16766/j.cnki.issn.1674-4152.002514

  • Clinical Laboratory, Yongkang First People's Hospital, Yongkang, Zhejiang 321300, China

Funds:

 2019RC305

  • Received Date: 2022-01-04
    Available Online: 2022-09-21
    Abstract
  •   Objective  To investigate the correlation of serum glycosylated haemoglobin (HbA1c), IL-6 and cystatin C (CysC) with the glomerular filtration rate (GFR) in elderly patients with diabetic nephropathy.  Methods  A total of 78 elderly patients with diabetic nephropathy who were treated in Yongkang First People's Hospital from January 2020 to June 2021 were selected as the observation group, and 77 elderly patients with simple diabetes who were treated in our hospital during the same period were selected as the control group. During the same period, 80 persons who underwent physical examination and were confirmed to be healthy were regarded as the healthy group. The levels of HbA1c, IL-6 and CysC and GFR were analysed in the three groups. GFR was determined by renal dynamic imaging method. The levels of various indexes in different stages of the observation group were compared. The correlation between the levels of HbA1c, IL-6 and CysC and GFR was further analysed.  Results  In the observation group, the HbA1c, IL-6, CysC and GFR were (8.15±1.94) %, (40.37±11.79) ng/L, (3.25±1.06) mg/L, (49.64±6.54) mL/min, respectively. In the control group, the HbA1c, IL-6, CysC and GFR were (7.24±1.15) %, (14.22±65.98) ng/L, (1.52±0.55) mg/L, (103.21±4.85) mL/min, respectively. In the healthy group, the HbA1c, IL-6, CysC and GFR were (5.16±0.33) %, (10.70±3.22) ng/L and (0.86±0.22) mg/L, (123.43±3.18) mL/min, respectively. The levels of HbA1c, IL-6 and CysC in the observation group were significantly higher than those in the other two groups. The levels of these indexes in the control group were higher than those in the healthy group (P < 0.05). The GFR in the observation group was significantly lower than those in the other two groups (P < 0.05). The GFR in the control group was lower than that in the healthy group (P < 0.05). With the increase of clinical stage, the levels of HbA1c, IL-6 and CysC gradually increased, and the GFR gradually decreased, and the differences between groups were statistically significant (all P < 0.05). The levels of HbA1c, IL-6 and CysC were negatively correlated with GFR levels in patients with diabetic nephropathy (r=-0.537, -0.838, -0.709, all P < 0.05).  Conclusion  The levels of HbA1c, IL-6 and CysC in patients with diabetic nephropathy are negatively correlated with the level of GFR. In clinical work, the levels of HbA1c, IL-6 and CysC can be measured to evaluate the patient's condition.

     

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