Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 1022-1026
HONG Xing, LI Rui, WEI Lu-gang, ZHANG Ping, ZHANG Peng-yue, LU Jing-yi. Research progress of rehabilitation effect and mechanism of traditional Chinese and Western medicine on skeletal muscle injury after stroke[J]. Chinese Journal of General Practice, 2022, 20(6): 1022-1026. doi: 10.16766/j.cnki.issn.1674-4152.002515
Citation: HONG Xing, LI Rui, WEI Lu-gang, ZHANG Ping, ZHANG Peng-yue, LU Jing-yi. Research progress of rehabilitation effect and mechanism of traditional Chinese and Western medicine on skeletal muscle injury after stroke[J]. Chinese Journal of General Practice, 2022, 20(6): 1022-1026. doi: 10.16766/j.cnki.issn.1674-4152.002515
shu

Research progress of rehabilitation effect and mechanism of traditional Chinese and Western medicine on skeletal muscle injury after stroke

doi: 10.16766/j.cnki.issn.1674-4152.002515
  • 1.

    Second Clinical Medical College of Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China

Funds:

 81960731

 81660384

  • Received Date: 2021-10-26
    Available Online: 2022-09-21
    Abstract
  • Stroke is a disease in which a blood vessel in the brain bursts or a blockage causes damage to brain tissue. Stroke is the second leading cause of death in the world and the main cause of disability, resulting in about 5.5 million deaths every year. About 60% of patients are disabled after stroke, bringing a great burden to their families and society. At present, the treatment of stroke focuses on restoring cerebral blood supply and treating nerve damage caused by stroke, but studies on the treatment of peripheral system disorders caused by stroke are relatively few. As the peripheral functional organ is affected by stroke, the damage of the nervous system after stroke will lead to muscle denervation, resulting in hemiplegia or decreased muscle strength. Lack of nerve innervation makes the muscle unable to produce the muscle strength required for movement, so daily tasks may not be completed. Various secondary changes occur in skeletal muscle during the whole process, including skeletal muscle weakness, skeletal muscle spasm and skeletal muscle atrophy, leading to limb dysfunction. Studies on the mechanism of skeletal muscle changes confirmed that skeletal muscle structure and metabolism change significantly after stroke, amongst which abnormal neuromuscular junction function, increased inflammatory markers in skeletal muscle, degradation of skeletal muscle protein and phenotypic transformation of muscle fibres are closely related to skeletal muscle dysfunction after stroke. Therefore, skeletal muscle repair and functional recovery after stroke are critical. Existing rehabilitation therapy showed that skeletal muscle recovery after stroke has a good repair effects, such as reducing the expression of inflammatory cytokines, recovery of neuromuscular connection link, strengthening the peripheral and central link and promoting the growth of muscle fibre, to achieve the recovery of limb function. In this paper, the rehabilitation of skeletal muscle after stroke was reviewed, and the relevant mechanisms were elucidated to provide a reference for the rehabilitation of skeletal muscle on the affected side after stroke.

     

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