Analysis of the expression and clinical significance of POSTN in head and neck squamous carcinoma based on TCGA database

ZHANG Man; ZHOU Lan-zhu; SUN Zhe; WU Jun; WANG Wen-zhong

doi:10.16766/j.cnki.issn.1674-4152.002525

Volume 20 Issue 6

Jun. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(6): 1066-1070

ZHANG Man, ZHOU Lan-zhu, SUN Zhe, WU Jun, WANG Wen-zhong. Analysis of the expression and clinical significance of POSTN in head and neck squamous carcinoma based on TCGA database[J]. Chinese Journal of General Practice, 2022, 20(6): 1066-1070. doi: 10.16766/j.cnki.issn.1674-4152.002525

Citation:

ZHANG Man, ZHOU Lan-zhu, SUN Zhe, WU Jun, WANG Wen-zhong. Analysis of the expression and clinical significance of POSTN in head and neck squamous carcinoma based on TCGA database[J]. Chinese Journal of General Practice, 2022, 20(6): 1066-1070. doi: 10.16766/j.cnki.issn.1674-4152.002525

Citation:

ZHANG Man, ZHOU Lan-zhu, SUN Zhe, WU Jun, WANG Wen-zhong. Analysis of the expression and clinical significance of POSTN in head and neck squamous carcinoma based on TCGA database[J]. Chinese Journal of General Practice, 2022, 20(6): 1066-1070. doi: 10.16766/j.cnki.issn.1674-4152.002525

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Analysis of the expression and clinical significance of POSTN in head and neck squamous carcinoma based on TCGA database

doi: 10.16766/j.cnki.issn.1674-4152.002525

Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

KJ2020A0568

Received Date: 2022-01-25
Available Online: 2022-09-21

Abstract

Abstract

Objective To analyse the clinical significance of POSTN differential expression in the diagnosis and prognosis of head and neck squamous cell carcinoma using online databases and bioinformatics methods and to find new biomarkers for this disease. Methods TCGA public database was used to obtain basic information of head and neck squamous carcinoma patients, the expression of POSTN and the correlation between POSTN and clinicopathological parameters of head and neck squamous carcinoma patients. The Kaplan-Meier Plotter was used to analyse the survival curve of head and neck squamous carcinoma patients with different POSTN expression levels. TIMER analysis was used to determine the correlation between POSTN and various immune cell infiltrations in head and neck squamous carcinoma. GEPIA database analysis was used to determine the correlation between POSTN expression and immune cell marker expression. GO and KEGG gene enrichment analysis were used to explore the function of differentially expressed genes and their pathways of action. Results POSTN was highly expressed in head and neck squamous carcinoma (P < 0.05), and its expression was positively correlated with prognosis of head and neck squamous carcinoma patients, the cumulative survival rate of head and neck squamous carcinoma patients was correlated with the degree of infiltration of multiple immune cells. POSTN expression level was positively correlated with the degree of macrophage infiltration in head and neck squamous carcinoma (P=0.024) and significantly positively correlated with M2 macrophage markers (P < 0.001), with high POSTN expression promoting macrophage polarisation towards M2 type. Enrichment analysis showed that POSTN was associated with extracellular matrix regulatory processes. Conclusion POSTN expression is associated with prognosis and immune infiltration in patients with head and neck squamous carcinoma, and it may contribute to poor patient prognosis by regulating macrophage polarisation.
- POSTN,
- Head and neck squamous carcinoma,
- Survival analysis,
- Immune infiltration,
- Macrophage polarisation

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Analysis of the expression and clinical significance of POSTN in head and neck squamous carcinoma based on TCGA database

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Analysis of the expression and clinical significance of POSTN in head and neck squamous carcinoma based on TCGA database

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