Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1102-1105
LI Yu-yu, MA Bo, XU Li. Therapeutic effect of sodium aescinate tablet combined with flunarizine hydrochloride in the treatment of migraine[J]. Chinese Journal of General Practice, 2022, 20(7): 1102-1105. doi: 10.16766/j.cnki.issn.1674-4152.002533
Citation: LI Yu-yu, MA Bo, XU Li. Therapeutic effect of sodium aescinate tablet combined with flunarizine hydrochloride in the treatment of migraine[J]. Chinese Journal of General Practice, 2022, 20(7): 1102-1105. doi: 10.16766/j.cnki.issn.1674-4152.002533
shu

Therapeutic effect of sodium aescinate tablet combined with flunarizine hydrochloride in the treatment of migraine

doi: 10.16766/j.cnki.issn.1674-4152.002533

  • Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 SK2018A0181

  • Received Date: 2021-07-17
    Available Online: 2022-09-23
    Abstract
  •   Objective  To explore the efficacy of sodium aescinate tablets combined with flunarizine hydrochloride capsules in the treatment of migraine and the occurrence of adverse reactions.  Methods  A total of 100 migraine patients diagnosed and treated in the First Affiliated Hospital of Bengbu Medical College from April 2020 to April 2021 were selected and divided into the control group (50 cases) and observation group (50 cases) according to the random number table method. The control group was treated with flunarizine hydrochloride capsule, whereas the observation group was treated with sodium aescinate tablets combined with flunarizine hydrochloride capsule. The treatment efficiency rate, pain score, cerebral blood flow velocity, high-sensitivity C-reactive protein (hs-CRP) level and occurrence of adverse reactions in the two groups were observed.  Results  There was no statistically significant difference in the basic data between the two groups before treatment, which was comparable. After treatment, the pain score of the observation group was (3.7±1.3) points, and that of the control group was (4.3±1.5) points. The pain score of the observation group was significantly reduced, and the difference was statistically significant (P < 0.05). After treatment, the total effective rate was 92.0% in the observation group and 70.0% in the control group, and the difference was statistically significant (P < 0.05). After treatment, the cerebral blood flow velocity of the anterior cerebral artery, middle cerebral artery, posterior cerebral artery and vertebral artery in the two groups decreased, and the decrease was more significant in the observation group, with statistical significance (P < 0.05). After treatment, the hs-CRP level in the observation group was (4.2±0.4) mg/L, and that in the control group was (4.5±0.6) mg/L. The decrease of the hs-CRP level in the observation group was more significant, and the difference was statistically significant (P < 0.05).  Conclusion  Sodium aescinate tablet combined with flunarizine hydrochloride capsule in the treatment of migraine can significantly increase the efficacy, significantly relieve the pain symptoms of patients, reduce the pain score, cerebral blood flow velocity and hs-CRP level, and does not increase adverse reactions.

     

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