Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1113-1116
DING Sheng, LEI Jia-sheng, WANG Dong-dong, ZHAO Guan-ru, MA Shuo-shuo, LU Zheng. Application of nomogram in the prognostic evaluation of patients after intrahepatic cholangiocarcinoma resection[J]. Chinese Journal of General Practice, 2022, 20(7): 1113-1116. doi: 10.16766/j.cnki.issn.1674-4152.002536
Citation: DING Sheng, LEI Jia-sheng, WANG Dong-dong, ZHAO Guan-ru, MA Shuo-shuo, LU Zheng. Application of nomogram in the prognostic evaluation of patients after intrahepatic cholangiocarcinoma resection[J]. Chinese Journal of General Practice, 2022, 20(7): 1113-1116. doi: 10.16766/j.cnki.issn.1674-4152.002536
shu

Application of nomogram in the prognostic evaluation of patients after intrahepatic cholangiocarcinoma resection

doi: 10.16766/j.cnki.issn.1674-4152.002536

  • Department of Hepatobiliary Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2008085MH256

 BYKY2019116ZD

 Byycxz20050

  • Received Date: 2021-11-19
    Available Online: 2022-09-23
    Abstract
  •   Objective  To analyse the survival factors of patients with intrahepatic cholangiocarcinoma after radical resection and establish a nomogram to evaluate whether the nomogram can effectively predict individual survival time.  Methods  The clinicopathological data of 80 patients with intrahepatic cholangiocarcinoma who underwent radical hepatectomy in the First Affiliated Hospital of Bengbu Medical College from January 2013 to December 2019 were retrospectively analysed. Cox regression model was used to analyse the independent risk factors affecting the survival of patients, and R language was used to establish survival nomogram of patients with intrahepatic cholangiocarcinoma after radical resection. The consistency index and calibration curve were used to verify the performance of the nomogram, and the area under the ROC curve (AUC) was used to compare the predictive effect of the nomogram and TNM staging on postoperative patient survival.  Results  Multivariate Cox analysis showed that CA19-9, tumour number, tumour differentiation and prognostic nutritional index were independent risk factors affecting the survival time of patients with intrahepatic cholangiocarcinoma after surgery, and a nomogram was constructed. The nomogram consistency index C was 0.692, and the calibration curve was close to the diagonal line, indicating that the nomogram had good differentiation and accuracy. The AUC values of the nomogram time-dependent ROC curve for predicting the 1-, 2- and 3-year survival rates of patients with intrahepatic cholangiocarcinoma after surgery were 0.783, 0.711 and 0.726, respectively. The AUC of the nomogram was 0.741, which was greater than that of TNM staging (0.509).  Conclusion  The nomogram constructed from CA19-9, tumour number, tumour differentiation and prognostic nutritional index is more effective than TNM staging in predicting the survival time of postoperative patients with intrahepatic cholangiocarcinoma and has the ability to estimate individual survival probability.

     

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