Volume 20 Issue 7
Jul.  2022
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1158-1161
WANG Jie-jie, WANG Guo-kai. Analysis of the curative effect of Yinzhihuang oral liquid combined with bifidobacterium tetragenous viable bacteria in the treatment of neonatal jaundice[J]. Chinese Journal of General Practice, 2022, 20(7): 1158-1161. doi: 10.16766/j.cnki.issn.1674-4152.002547
Citation: WANG Jie-jie, WANG Guo-kai. Analysis of the curative effect of Yinzhihuang oral liquid combined with bifidobacterium tetragenous viable bacteria in the treatment of neonatal jaundice[J]. Chinese Journal of General Practice, 2022, 20(7): 1158-1161. doi: 10.16766/j.cnki.issn.1674-4152.002547
shu

Analysis of the curative effect of Yinzhihuang oral liquid combined with bifidobacterium tetragenous viable bacteria in the treatment of neonatal jaundice

doi: 10.16766/j.cnki.issn.1674-4152.002547

  • Department of Pediatrics, the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230000, China

Funds:

 gxyqZD2019035

  • Received Date: 2021-06-22
    Available Online: 2022-09-23
    Abstract
  •   Objective  To evaluate the efficacy and safety of the combined application of bifidobacterium tetragenous viable bacteria and Yinzhihuang oral liquid in the treatment of neonatal jaundice.  Methods  Total 50 patients with neonatal jaundice in the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from May 2019 to December 2020 were selected and randomly divided into control and observation groups, with 25 cases in each group. Both groups were treated with blue light phototherapy and oral administration of liver enzyme inducer phenobarbital. The control group was treated with conventional treatment + bifidobacterium tetragenous viable bacteria 0.5 g with warm water three times/day. On the basis of the control group, the observation group was treated with Yinzhihuang oral liquid 5 mL/time, oral, 3 times/d. The differences of various indexes between the two groups before and after treatment were compared.  Results  There was no significant difference in total bilirubin, direct bilirubin and indirect bilirubin between the two groups before treatment (all P > 0.05). After treatment, there was no significant difference in indirect bilirubin between the two groups (P > 0.05), meanwhile, the total bilirubin and indirect bilirubin of the observation group [(118.78±23.43) and (106.89±22.39) μmol/L] were significantly lower than those of the control group [(135.41±28.66) and (123.31±27.77) μmol/L, all P < 0.05]. The incidence of adverse reactions in the observation group was 4.00% (1/25), and that in the control group was 24.00% (6/25). There was no statistically significant difference between the two groups (P > 0.05). The total time of phototherapy, the total cost of phototherapy and the length of stay in the observation group were significantly lower than those in the control group, and the difference was statistically significant (all P < 0.05).  Conclusion  On the basis of conventional treatment for neonatal jaundice, the combined application of bifidobacterium tetragenous viable bacteria and Yinzhihuang oral liquid has a significant clinical effect, reduces hospitalisation time and the cost of phototherapy, and is a safe and effective treatment method.

     

    • FullText(HTML)
  • loading
    • References(24)
  • [1]
    陈萍. 益生菌和维生素B2结合蓝光治疗新生儿高胆红素血症的疗效观察及分析[J]. 贵州医药, 2019, 43(6): 941-942. https://www.cnki.com.cn/Article/CJFDTOTAL-GZYI201906038.htm

    CHEN P. Effects of probiotics and vitamin B2 combined with blue light on neonatal hyperbilirubinemia effect observation and analysis[J]. Guizhou Medical Journal, 2019, 43(6): 941-942. https://www.cnki.com.cn/Article/CJFDTOTAL-GZYI201906038.htm
    [2]
    IWATANI S, BURGESS J, KALISH F, et al. Bilirubin production is increased in newborn nice exposed to isoflurane[J]. Neonatology, 2019, 115(1): 21-27. doi: 10.1159/000492421
    [3]
    SLUSHER T M, ZAMORA T G, APPIAH D, et al. Burden of severe neonatal jaundice: A systematic review and meta-analysis[J]. BMJ Paediatr Open, 2017, 1(1): e000105. DOI: 10.1136/bmjpo-2017-000105.
    [4]
    0LUSANYA B O, KAPLAN M, HANSEN T W R. Neonatal hyperbilirubinaemia: A global perspective[J]. Lancet Child Adolesc Health, 2018, 2(8): 610-620. doi: 10.1016/S2352-4642(18)30139-1
    [5]
    陈芳芳, 李崇寿, 倪王平. 间隙和持续蓝光照射治疗新生儿黄疸的临床效果研究[J]. 中国保健营养, 2019, 29(1): 126-127. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201202025.htm

    CHEN F F, LI C S, NI W P. Effect of intermittent and continuous blue light irradiation on neonatal jaundice Clinical effect research[J]. 中国保健营养, 2019, 29(1): 126-127. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201202025.htm
    [6]
    麦静仪, 饶晓林. 早期不同蓝光照射方案治疗新生儿黄疸的效果及安全性观察[J]. 现代诊断与治疗, 2020, 31(1): 91-92. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZD202001048.htm

    MAI J Y, RAO X L. Effect of different blue light irradiation schemes on neonatal jaundice and safety observatio[J]. Modern Diagnosis and Treatment, 2020, 31(1): 91-92. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZD202001048.htm
    [7]
    袁丽君. 新生黄疸患儿行LED冷光源与常规蓝光光疗的治疗效果及其不良反应[J]. 临床研究, 2020, 28(1): 125-126. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY201919026.htm

    YUAN L J. Therapeutic effect of LED cold light source and conventional blue light therapy on neonatal jaundice and its adverse reactions[J]. Clinical Research, 2020, 28(1): 125-126. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY201919026.htm
    [8]
    王卫平, 孙锟. 儿科学[M]. 北京: 人民卫生出版社, 2018: 112-114.

    WANG W P, SUN K. Pediatrics[M]. Beijing: People's Health Publishing House, 2018: 112-114.
    [9]
    国家中医药管理局. 中华人民共和国中医药行业标准《中医内科病证诊断疗效标准》——胎黄的诊断依据、证候分类、疗效评定(ZY/T001.1-94)[J]. 辽宁中医药大学学报, 2017, 19(10): 131. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB201710043.htm

    The State Administration of traditional Chinese medicine. Chinese medicine industry standard of the people's Republic of China Criteria for diagnosis and curative effect of disease and syndrome - diagnostic basis, syndrome classification and curative effect evaluation of fetal yellow (ZY /T001.1-94)[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2017, 19(10): 131. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB201710043.htm
    [10]
    VITEK L. Bilirubin as a signaling molecule[J]. Med Res Rev, 2020, 40(4): 1335-1351. doi: 10.1002/med.21660
    [11]
    HANSEN T W R, WONG R J, STRVENSON D K. Molecular physiology and pathophysiology of bilirubin handling by the blood, liver, intestine, and brain in the newborn[J]. Physiol Rev, 2020, 100(3): 1291-1346. doi: 10.1152/physrev.00004.2019
    [12]
    张士发, 茅双根. 新生儿黄疸的诊断与治疗[J]. 中华全科医学, 2016, 14(7): 1064-1065. http://www.zhqkyx.net/article/id/98724073-8741-49c7-90bd-02b7011b82fc

    ZHANG S F, MAO S G. Diagnosis and treatment of neonatal jaundice[J]. Chinese Journal of General Practice, 2016, 14(7): 1064-1065. http://www.zhqkyx.net/article/id/98724073-8741-49c7-90bd-02b7011b82fc
    [13]
    LAI K, SONG X L, SHI H S, et al. Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice[J]. Sci Transl Med, 2020, 12(530): eaax1337. DOI: 10.1126/scitranslmed.aax1337.
    [14]
    申艳泉. 观察间隙和持续蓝光光疗对新生儿病理性黄疸的临床治疗效果[J]. 中国社区医师, 2019, 35(16): 65. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYS201916045.htm

    SHEN Y Q. Clinical observation of intermittent and continuous blue light phototherapy on neonatal pathological jaundice therapeutic effect[J]. Chinese Community Physicians, 2019, 35(16): 65. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYS201916045.htm
    [15]
    LI Y B, ZHOU W, YYAN W M, et al. Composition of gut microbiome in neonates with severe hyperbilirubinemia and its effect on bilirubin brain injury[J]. Chin J Appl Clin Pediatr, 2018, 33(2): 103-107.
    [16]
    DONG T, CHEN T, WHITE R, et al. Meconium microbiome associates with the development of neonatal jaundice[J]. Clin Transl Gastroenterol, 2018, 9(9): 182. doi: 10.1038/s41424-018-0048-x
    [17]
    YANG N, YANG R X, WANG A H, et al. The effect of intestinal flora on the neural development of severe hyperbilirubinemia neonates[J]. Eur Rev Med Pharmacol Sci, 2019, 23(3): 1291-1295.
    [18]
    胡文文. 双歧杆菌四联活菌片联合蓝光治疗新生儿高胆红素血症的临床疗效[J]. 中国处方药, 2020, 18(2): 64-65. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCF202002037.htm

    HU W W. Treatment of neonatal hyperbilirubinemia with Bifidobacterium tetra viable tablets combined with blue light[J]. Chinese Prescription Drugs, 2020, 18(2): 64-65. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCF202002037.htm
    [19]
    徐桂林. 双歧杆菌四联活菌片辅助蓝光照射治疗新生儿黄疸的疗效观察[J]. 现代诊断与治疗, 2017, 28(19): 3674-3675. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZD201719092.htm

    XU G L. Treatment of neonatal jaundice with Bifidobacterium tetra viable tablets assisted by blue light irradiation curative effect observation[J]. Modern Diagnosis and Treatment, 2017, 28(19): 3674-3675. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZD201719092.htm
    [20]
    聂小红. 间隙蓝光照射联合双歧杆菌四联活菌片治疗新生儿黄疸的临床效果[J]. 中外医学研究, 2019, 17(6): 151-152. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201906073.htm

    NIE X H. Intermittent blue light irradiation combined with Bifidobacterium tetra live tablets in the treatment of neonatal jaundice clinical effect of jaundice[J]. Chinese and Foreign Medical Research, 2019, 17(6): 151-152. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201906073.htm
    [21]
    刘玉萍, 邱小玉, 刘烨, 等. 茵陈的药理作用研究进展[J]. 中草药, 2019, 50(9): 228-234. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201909033.htm

    LIU Y P, QIU X Y, LIU Y, et al. Research progress on pharmacological action of Artemisia capillaris[J]. Chinese Traditional and Herbal Drugs, 2019, 50(9): 228-234. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201909033.htm
    [22]
    罗菁, 卢洪萍. 茵栀黄口服液联合培菲康对新生儿黄疸的疗效及对T细胞亚群的影响[J]. 中华全科医学, 2017, 15(3): 463-465. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.031

    LUO J, LU H P. Clinical effect and influence on T cell subsets of Yinzhihuang oral solution combined Bifico in patients with neonatal jaundice[J]. Chinese Journal of General Practice, 2017, 15(3): 463-465. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.031
    [23]
    田艳华, 高永伟, 张永娇, 等. 蓝光间歇照射与蓝光持续照射辅助黄疸茵陈颗粒治疗新生儿黄疸疗效分析[J]. 山西医药杂志, 2019, 48(17): 2152-2153. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYY201917030.htm

    TIAN Y H, GAO Y W, ZHANG Y J, et al. Intermittent blue light irradiation and continuous blue light irradiation analysis of curative effect of jaundice Yinchen Granule on neonatal jaundice[J]. Shanxi Medical Journal, 2019, 48(17): 2152-2153. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYY201917030.htm
    [24]
    韩姗姗, 陈文霞, 苏素静, 等. 基于GRADE系统的茵栀黄口服液联合常规疗法治疗新生儿黄疸的循证分析[J]. 中成药, 2019, 41(2): 321-326. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA201902016.htm

    HAN S S, CHEN W X, SU J, et al. Evidence-based analysis of Yinzhihuang Oral Liquid combined with conventional therapy in treating neonatal jaundice based on GRADE system[J]. Chinese Traditional Patent Medicine, 2019, 41(2): 321-326. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA201902016.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (310) PDF downloads(1) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return