Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1158-1161
WANG Jie-jie, WANG Guo-kai. Analysis of the curative effect of Yinzhihuang oral liquid combined with bifidobacterium tetragenous viable bacteria in the treatment of neonatal jaundice[J]. Chinese Journal of General Practice, 2022, 20(7): 1158-1161. doi: 10.16766/j.cnki.issn.1674-4152.002547
Citation: WANG Jie-jie, WANG Guo-kai. Analysis of the curative effect of Yinzhihuang oral liquid combined with bifidobacterium tetragenous viable bacteria in the treatment of neonatal jaundice[J]. Chinese Journal of General Practice, 2022, 20(7): 1158-1161. doi: 10.16766/j.cnki.issn.1674-4152.002547
shu

Analysis of the curative effect of Yinzhihuang oral liquid combined with bifidobacterium tetragenous viable bacteria in the treatment of neonatal jaundice

doi: 10.16766/j.cnki.issn.1674-4152.002547

  • Department of Pediatrics, the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230000, China

Funds:

 gxyqZD2019035

  • Received Date: 2021-06-22
    Available Online: 2022-09-23
    Abstract
  •   Objective  To evaluate the efficacy and safety of the combined application of bifidobacterium tetragenous viable bacteria and Yinzhihuang oral liquid in the treatment of neonatal jaundice.  Methods  Total 50 patients with neonatal jaundice in the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from May 2019 to December 2020 were selected and randomly divided into control and observation groups, with 25 cases in each group. Both groups were treated with blue light phototherapy and oral administration of liver enzyme inducer phenobarbital. The control group was treated with conventional treatment + bifidobacterium tetragenous viable bacteria 0.5 g with warm water three times/day. On the basis of the control group, the observation group was treated with Yinzhihuang oral liquid 5 mL/time, oral, 3 times/d. The differences of various indexes between the two groups before and after treatment were compared.  Results  There was no significant difference in total bilirubin, direct bilirubin and indirect bilirubin between the two groups before treatment (all P > 0.05). After treatment, there was no significant difference in indirect bilirubin between the two groups (P > 0.05), meanwhile, the total bilirubin and indirect bilirubin of the observation group [(118.78±23.43) and (106.89±22.39) μmol/L] were significantly lower than those of the control group [(135.41±28.66) and (123.31±27.77) μmol/L, all P < 0.05]. The incidence of adverse reactions in the observation group was 4.00% (1/25), and that in the control group was 24.00% (6/25). There was no statistically significant difference between the two groups (P > 0.05). The total time of phototherapy, the total cost of phototherapy and the length of stay in the observation group were significantly lower than those in the control group, and the difference was statistically significant (all P < 0.05).  Conclusion  On the basis of conventional treatment for neonatal jaundice, the combined application of bifidobacterium tetragenous viable bacteria and Yinzhihuang oral liquid has a significant clinical effect, reduces hospitalisation time and the cost of phototherapy, and is a safe and effective treatment method.

     

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