Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1166-1169
ZHU Zhong-xin, SHENG Li-fang, YAO Xiao-cong. Association between number of pregnancies and bone mineral density in older females[J]. Chinese Journal of General Practice, 2022, 20(7): 1166-1169. doi: 10.16766/j.cnki.issn.1674-4152.002549
Citation: ZHU Zhong-xin, SHENG Li-fang, YAO Xiao-cong. Association between number of pregnancies and bone mineral density in older females[J]. Chinese Journal of General Practice, 2022, 20(7): 1166-1169. doi: 10.16766/j.cnki.issn.1674-4152.002549
shu

Association between number of pregnancies and bone mineral density in older females

doi: 10.16766/j.cnki.issn.1674-4152.002549
  • 1.

    Department of Osteoporosis Care and Control, Xiaoshan First Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 311200, China

Funds:

 2021RC119

  • Received Date: 2021-09-07
    Available Online: 2022-09-23
    Abstract
  •   Objective  The rapid mineralisation of foetal bones in the third trimester and the continuous loss of calcium from breast milk during lactation may lead to the loss of bone mass and the decline of bone mineral density (BMD) in pregnant women. However, evidence regarding the association between number of pregnancies and risk of osteoporosis in older females remains limited and inconsistent. Thus, we aimed to explore the association between number of pregnancies and BMD using a population-based sample database.  Methods  We conducted a study on older females aged 60-80 years with complete data who participated in the National Health and Nutrition Examination Survey (NHANES) in 2007-2010, 2013-2014 and 2017-2018. The independent variable was number of pregnancies. The dependent variable was BMD. We performed multivariable regression models to evaluate the associations between number of pregnancies and BMD.  Results  There were 2 096 subjects in the final analysis, including 264 subjects with one child [age=(67.5±6.1) years], 593 subjects with two children [age=(67.9±6.5) years], 506 subjects with three children [age=(69.5±6.6) years] and 733 subjects with four children or more [age=(71.7±6.5) years]. In the fully adjusted model, there were no significant associations in number of pregnancies with femoral neck BMD, total femur BMD, or Ward's triangle BMD after adjusting for age, race, marital status, time of last menstrual period, education level, moderate exercise, family income to poverty ratio, body mass index, blood urea nitrogen, serum uric acid, serum phosphorus and serum calcium (all P > 0.05).  Conclusion  Having two or multiple births is not a risk factor for osteoporosis for women at old age.

     

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