Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1190-1193
ZHANG De-sheng, ZHU Xiao-lei, HE Jian, ZHENG Yi-feng, WU Xiao, CHU Hai-Rui, GUO Dong-chuang. Value of high-strength MRI combined with serum CYFRA21-1, CA72-4 and CA125 in identifying T staging of oesophageal cancer[J]. Chinese Journal of General Practice, 2022, 20(7): 1190-1193. doi: 10.16766/j.cnki.issn.1674-4152.002555
Citation: ZHANG De-sheng, ZHU Xiao-lei, HE Jian, ZHENG Yi-feng, WU Xiao, CHU Hai-Rui, GUO Dong-chuang. Value of high-strength MRI combined with serum CYFRA21-1, CA72-4 and CA125 in identifying T staging of oesophageal cancer[J]. Chinese Journal of General Practice, 2022, 20(7): 1190-1193. doi: 10.16766/j.cnki.issn.1674-4152.002555
shu

Value of high-strength MRI combined with serum CYFRA21-1, CA72-4 and CA125 in identifying T staging of oesophageal cancer

doi: 10.16766/j.cnki.issn.1674-4152.002555
  • 1.

    Department of Radiology, Affiliated Central Hospital of Huzhou Normal University, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China

Funds:

 2020KY303

  • Received Date: 2021-03-25
    Available Online: 2022-09-23
    Abstract
  •   Objective  To analyse the value of high-strength MRI combined with serum cytokeratin 19 fragment (CYFRA21-1), carbohydrate antigen 72-4 (CA72-4) and carbohydrate antigen 125 (CA125) in identifying T staging of oesophageal cancer.  Methods  From July 2017 to January 2020, 104 patients with esophageal cancer who were to be surgically treated in Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine and Huzhou Central Hospital were selected as research objects. The image quality of high-field-intensity MRI and the value of high-field-intensity MRI combined with serum CYFRA21-1, CA72-4, CA125 were analysed. Kappa consistency analysis was used in identifying T staging of oesophageal cancer.  Results  There were 6 cases with high-strength MRI image quality scoring 2 points, 16 cases scoring 3 points, 40 cases scoring 4 points and 42 cases scoring 5 points. The accuracy of high-strength MRI for the diagnosis of T staging of oesophageal cancer was 92.30% (96/104). The accuracy rate of high-strength MRI combined with serum CYFRA21-1, CA72-4 and CA125 for the diagnosis of T staging of oesophageal cancer was 95.19% (99/104), which was significantly different from that of single MRI (P < 0.05). However, the specificity, accuracy, positive predictive value for stage T2; sensitivity, specificity, accuracy, positive predictive value, negative predictive value for stage T3; and sensitivity, accuracy, negative predictive value for stage T4a of combined diagnosis were higher than those of single high-strength MRI.  Conclusion  Single high-strength MRI or its combination with serum CYFRA21-1, CA72-4 and CA125 can effectively identify the T staging of oesophageal cancer, and the efficiency of combined diagnosis is slightly improved.

     

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