Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1226-1229
ZHANG Ru-shan, TANG Gen-fu, WANG Rui, ZOU Jian-fei, XU Ya-ping, ZHANG Xu, CHEN Hao, WU Qian. The relationship between low-density lipoprotein cholesterol and mild decline of renal function in hypertensive patients of Anqing rural area[J]. Chinese Journal of General Practice, 2022, 20(7): 1226-1229. doi: 10.16766/j.cnki.issn.1674-4152.002564
Citation: ZHANG Ru-shan, TANG Gen-fu, WANG Rui, ZOU Jian-fei, XU Ya-ping, ZHANG Xu, CHEN Hao, WU Qian. The relationship between low-density lipoprotein cholesterol and mild decline of renal function in hypertensive patients of Anqing rural area[J]. Chinese Journal of General Practice, 2022, 20(7): 1226-1229. doi: 10.16766/j.cnki.issn.1674-4152.002564
shu

The relationship between low-density lipoprotein cholesterol and mild decline of renal function in hypertensive patients of Anqing rural area

doi: 10.16766/j.cnki.issn.1674-4152.002564

  • School of Health Service Management, Anhui Medical University, Hefei, Anhui 230032, China

Funds:

 81773534

  • Received Date: 2021-12-17
    Available Online: 2022-09-23
    Abstract
  •   Objective  To evaluate the relationship between plasma low density lipoprotein cholesterol and mild decline of renal function, and provide clues for early prevention of hypertension complicated with chronic kidney disease.  Methods  In this study, a multi-stage random sampling method was used in seven randomly selected townships of Anqing City rural areas from June to September 2020, including 1 959 hypertensive patients. The general information and plasma low density lipoprotein cholesterol level of the subjects were obtained and logistic regression was used to analyze the relationship between LDL-C and mild decline of renal function.  Results  The average age of 1 959 hypertensive patients was (69.2±7.0) years, including 1 231 patients with mild renal dysfunction (62.8%). After optimizing gender and other related factors, there was a significant positive correlation between LDL-C and mild renal decline in hypertensive patients. When plasma LDL-C increased by 1 mmol/L, the risk of mild renal decline will increase 57% in patients with hypertension (OR=1.570, 95% CI: 1.359-1.813). Dividing LDL-C concentrations into 3 grades, compared with the patients with the lowest tertile of LDL-C (T1, < 2.2 mmol/L), the patients with the median tertile of LDL-C (T2, ≥2.2 and < 2.9 mmol/L) and the highest teitile of LDL-C (T3, ≥2.9 mmol/L) had a 1.028-fold (OR=2.028, 95% CI: 1.578-2.605) and 2.721-fold (OR=3.721, 95% CI: 2.814-4.920) increased risk of mild renal decline, respectively. In addition, there was a synergistic effect on increasing the risk of mild renal decline between elevated diastolic blood pressure and increased LDL-C levels (diastolic blood pressure < 90 mm Hg vs ≥ 90 mm Hg, 1 mm Hg=0.133 kPa, P for interaction=0.006).  Conclusion  There was a positive correlation between LDL-C and mild renal function decline in hypertensive patients, especially in those with increased diastolic blood pressure. It is suggested that controlling LDL-C and blood pressure in patients with hypertension can reduce the risk of mild renal function decline and reduce the early damage of renal target organs.

     

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