Volume 20 Issue 8
Aug.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(8): 1307-1310
GAO Xiong, TANG Zhen, GONG Hui-yuan, LI Wei, ZHANG Lei, WANG Biao. Exploration of the pattern of lung hilar lymph node metastasis in cTNM-stage IA non-small cell lung cancer and its clinical significance[J]. Chinese Journal of General Practice, 2022, 20(8): 1307-1310. doi: 10.16766/j.cnki.issn.1674-4152.002583
Citation: GAO Xiong, TANG Zhen, GONG Hui-yuan, LI Wei, ZHANG Lei, WANG Biao. Exploration of the pattern of lung hilar lymph node metastasis in cTNM-stage IA non-small cell lung cancer and its clinical significance[J]. Chinese Journal of General Practice, 2022, 20(8): 1307-1310. doi: 10.16766/j.cnki.issn.1674-4152.002583
shu

Exploration of the pattern of lung hilar lymph node metastasis in cTNM-stage IA non-small cell lung cancer and its clinical significance

doi: 10.16766/j.cnki.issn.1674-4152.002583

  • Department of Thoracic Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2020b07030008

  • Received Date: 2021-07-22
    Available Online: 2022-09-26
    Abstract
  •   Objective  To investigate the metastasis pattern of hilar lymph nodes (group 10 lymph nodes) in cTNM-ⅠA stage non-small cell lung cancer (NSCLC) and the clinical significance.  Methods  A retrospective analysis of tumor and lymph node pathology was performed in 233 patients with primary cTNM-stage Ⅰ NSCLC, who underwent lobectomy and systemic lymph node dissection from January 1, 2020 to January 1, 2021 in the thoracic surgery ward of the First Affiliated Hospital of Bengbu Medical College.  Results  A total of 3 145 lymph nodes were obtained from 233 patients, with an average of 13.5 lymph nodes per case, and 440 lymph nodes had cancer metastasis, with a metastasis rate of 14.0%. Among the 233 patients, 49 cases had intrathoracic lymph node metastasis, including 16 cases of N1, 25 cases of N1+N2 [Note: N1: metastasis of intrapulmonary lymph nodes alone; N1+N2: metastasis of N2 (mediastinal group 2-9 lymph nodes) and N1 (intrapulmonary group 10-14 lymph nodes) at the same time] and 8 cases of skipping status N2, with a total metastasis rate of 21.0% (49/233). Among them, 10 cases were positive for group 10 lymph nodes in N1, accounting for 62.5% (10/16), and 18 cases were positive for group 10 lymph nodes in N1+N2, accounting for 72.0% (18/25). The difference in metastasis rate of lymph nodes in group 10 was statistically significant between stage T1b and stage T1a (P < 0.05), and the metastasis rates of lymph nodes in group 10 in poorly and moderately differentiated lung cancer were 25.9% (21/81) and 8.3% (7/84), respectively, the difference was statistically significant (χ2=9.060, P < 0.05).  Conclusion  In NSCLC, group 10 lymph node metastasis is closely related to the primary tumor size, clinicopathological type and differentiation degree. In the case of lymph node metastasis in N1, N1+N2 and N2, the possibility of positive lymph node in group 10 is higher. Therefore, pathological detection of group 10 lymph nodes is a priority when NSCLC patients need a surgical operation, and it is more scientific to decide the subsequent surgical plan, depending on the pathological results.

     

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