Volume 20 Issue 8
Aug.  2022
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(8): 1311-1314
WU Shu-lu, NIU Kai-xuan, XU Yang, LIU Cheng, DENG Xi-ming. Effects of antiplatelet therapy on inflammatory response, platelet function and therapeutic effect of sepsis[J]. Chinese Journal of General Practice, 2022, 20(8): 1311-1314. doi: 10.16766/j.cnki.issn.1674-4152.002584
Citation: WU Shu-lu, NIU Kai-xuan, XU Yang, LIU Cheng, DENG Xi-ming. Effects of antiplatelet therapy on inflammatory response, platelet function and therapeutic effect of sepsis[J]. Chinese Journal of General Practice, 2022, 20(8): 1311-1314. doi: 10.16766/j.cnki.issn.1674-4152.002584
shu

Effects of antiplatelet therapy on inflammatory response, platelet function and therapeutic effect of sepsis

doi: 10.16766/j.cnki.issn.1674-4152.002584

  • Department of Intensive Care, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0351

  • Received Date: 2021-10-16
    Available Online: 2022-09-26
    Abstract
  •   Objective  To investigate the anti-inflammatory effect and safety of antiplatelet drug aspirin in patients with sepsis.  Methods  A total of 61 sepsis patients admitted to the Department of Intensive Care Medicine of the First Affiliated Hospital of Bengbu Medical College from October 2020 to June 2021 were selected, including 31 patients in the control group and 30 patients in the experimental group. The control group received conventional sepsis treatment, and the experimental group received conventional treatment + aspirin 100 mg, one time a day, by gastric tube injection, once a day, for 7 days. Changes in the levels of procalcitonin, C-reactive protein and interleukin-6, coagulation function (prothrombin time, thrombin time and activated partial thrombin time), and platelet count and function (MA value in thromboelastic diagram) were compared between the two groups before and after treatment. The incidence of common adverse reactions (gastrointestinal bleeding) and treatment efficiency of aspirin were observed.  Results  After treatment, the levels of PCT, CRP and IL-6 in the two groups decreased, and the decreased levels in the experimental group were significantly higher than those in the control group (P=0.012, 0.006 and 0.043, respectively). There were no significant differences in coagulation function (prothrombin time, thrombin time and activated partial thromboplastin time) and platelet count PLT between the two groups (all P>0.05). The change in platelet function index MA in the experimental group was statistically different from that in the control group (P=0.023). There was no statistical difference in the incidence of aspirin side effects between the two groups (P=0.694). After treatment, acute physiology and chronic health evaluation Ⅱ and sequential organ failure assessment scores in the experimental group were significantly lower than those in the control group, with statistical differences (P=0.048, 0.028). There was no statistical difference in the therapeutic effect between the two groups (P=0.344).  Conclusion  The antiplatelet drug aspirin can control the inflammatory response in patients with sepsis, and it has no obvious inhibition on coagulation function, platelet count and function. It does not increase the incidence of bleeding in patients, but it does not improve the patients' final treatment outcome.

     

    • FullText(HTML)
  • loading
    • References(18)
  • [1]
    SINGER M, DEUTSCHMAN C S, SEYMOUR C W, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3)[J]. JAMA, 2016, 315(8): 801-810. doi: 10.1001/jama.2016.0287
    [2]
    WANG Y H, OUYANG Y Q, LIU B Y, et al. Platelet activation and antiplatelet therapy in sepsis: A narrative review[J]. Thromb Res, 2018, 166: 28-36. doi: 10.1016/j.thromres.2018.04.007
    [3]
    KIERS D, VAN DER HEIJDEN WA, VAN EDE L, et al. A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia[J]. Thromb Haemost, 2017, 117(9): 1798-1807. doi: 10.1160/TH16-10-0799
    [4]
    OSTHOFF M, SIDLER J A, LAKATOS B, et al. Low-dose acetylsalicylic acid treatment and impact on short-term mortality in staphylococcus aureus bloodstream infection: A propensity score-matched cohort study[J]. Crit Care Med, 2016, 44(4): 773-781. doi: 10.1097/CCM.0000000000001554
    [5]
    吴晓飞. 脓毒症的诊断和治疗[J]. 中华全科医学, 2014, 12(10): 1538-1539. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201410002.htm

    WU X F. Diagnosis and treatment of sepsis[J]. Chinese Journal of General Practice, 2014, 12(10): 1538-1539. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201410002.htm
    [6]
    VARDON-BOUNES F, RUIZ S, GRATACAP M P, et al. Platelets are critical key players in sepsis[J]. Int J Mol Sci, 2019, 20(14): 3494. doi: 10.3390/ijms20143494
    [7]
    王怡宁, 汪松, 陆元兰, 等. 血小板在脓毒症及其所致器官功能障碍发病中作用的研究进展[J]. 山东医药, 2018, 58(30): 100-102. doi: 10.3969/j.issn.1002-266X.2018.30.029

    WANG Y N, WANG S, LU Y L, et al. Research progress on the role of platelets in the pathogenesis of sepsis and organ dysfunction[J]. Shandong Medical Journal, 2018, 58(30): 100-102. doi: 10.3969/j.issn.1002-266X.2018.30.029
    [8]
    KIM S J, DAVIS R P, JENNE C N. Platelets as modulators of inflammation[J]. Semin Thromb Hemost, 2018, 44(2): 91-101. doi: 10.1055/s-0037-1607432
    [9]
    HANNACHI N, OGÉ-GANAYE E, BAUDOIN J P, et al. Antiplatelet agents have a distinct efficacy on platelet aggregation induced by infectious bacteria[J]. Front Pharmacol, 2020, 11: 863. doi: 10.3389/fphar.2020.00863
    [10]
    POORANI R, BHATT A N, DWARAKANATH B, et al. COX-2, Aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance[J]. Eur J Pharmacol, 2016, 785: 116-132. doi: 10.1016/j.ejphar.2015.08.049
    [11]
    JAIN N, PHADNIS M A, MARTIN B C, et al. Potent antiplatelet therapy may reduce death from sepsis in patients on chronic dialysis[J]. Am J Cardiol, 2022, 162: 209-211. doi: 10.1016/j.amjcard.2021.10.001
    [12]
    HAMID U KRASNODEMBSKAYA A, FITZGERALD M, et al. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS[J]. Thorax, 2017, 72(11): 971-980. doi: 10.1136/thoraxjnl-2016-208571
    [13]
    CASEY J D, SEMLER M W, BASTARACHE J A, et al. Aspirin for sepsis prophylaxis: An ounce of prevention?[J]. Crit Care Med, 2017, 45(11): 1959-1960. doi: 10.1097/CCM.0000000000002669
    [14]
    WIEWEL M A, DE STOPPELAAR S F, VAN VUGHT L A, et al. Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: A propensity-matched analysis[J]. Intensive Care Med, 2016, 42(3): 352-360. doi: 10.1007/s00134-015-4171-9
    [15]
    AL HARBI S A, TAMIM H M, AL-DORZI H M, et al. Association between Aspirin therapy and the outcome in critically ill patients: A nested cohort study[J]. BMC Pharmacol Toxicol, 2016, 17: 5. doi: 10.1186/s40360-016-0047-z
    [16]
    EIZAYAGA F X, BELON P, DESPLAT V, et al. Effects of ultra-low-dose Aspirin in thrombosis and haemorrhage[J]. Homeopathy, 2019, 108(3): 158-168. doi: 10.1055/s-0038-1677495
    [17]
    徐波. 血小板聚集率、血小板功能在评价脓毒症患者预后的价值[J]. 血栓与止血学, 2020, 26(6): 953-955. doi: 10.3969/j.issn.1009-6213.2020.06.022

    XU B. The value of platelet aggregation rate and platelet function in evaluating the prognosis of sepsis[J]. Chinese Journal of Thrombosis and Hemostasis, 2020, 26(6): 953-955. doi: 10.3969/j.issn.1009-6213.2020.06.022
    [18]
    姜丽静, 倪金迪, 李何昊, 等. 血栓弹力图指导抗血小板治疗在冠状动脉支架植入术后患者中的应用[J]. 血栓与止血学, 2022, 28(4): 541-542, 545. https://www.cnki.com.cn/Article/CJFDTOTAL-XSZX202203082.htm

    JIANG J L, NI J D, LI H H, et al. Thromboelastography to guide the application of antiplatelet therapy in patients after coronary artery stent implantation[J]. Chinese Journal of Thrombosis and Hemostasis, 2022, 28(4): 541-542, 545. https://www.cnki.com.cn/Article/CJFDTOTAL-XSZX202203082.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(6)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (186) PDF downloads(10) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return