Volume 20 Issue 8
Aug.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(8): 1376-1379
GUAN Jing-jing, SHI Peng, LI Bao-wu, LIU Bei-bei, SUI Yang, ZHOU Ping-hui, CHEN Yu. Value evaluation of carotid atherosclerotic plaque ultrasound combined with blood lipid index in predicting cardiovascular disease[J]. Chinese Journal of General Practice, 2022, 20(8): 1376-1379. doi: 10.16766/j.cnki.issn.1674-4152.002601
Citation: GUAN Jing-jing, SHI Peng, LI Bao-wu, LIU Bei-bei, SUI Yang, ZHOU Ping-hui, CHEN Yu. Value evaluation of carotid atherosclerotic plaque ultrasound combined with blood lipid index in predicting cardiovascular disease[J]. Chinese Journal of General Practice, 2022, 20(8): 1376-1379. doi: 10.16766/j.cnki.issn.1674-4152.002601
shu

Value evaluation of carotid atherosclerotic plaque ultrasound combined with blood lipid index in predicting cardiovascular disease

doi: 10.16766/j.cnki.issn.1674-4152.002601
  • 1.

    Health Management Center, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 31700854

  • Received Date: 2022-01-25
    Available Online: 2022-09-26
    Abstract
  •   Objective  To conduct the value evaluation of carotid atherosclerotic plaque ultrasound combined with blood lipid index in predicting cardiovascular disease.  Methods  Fifty-nine physical examination patients diagnosed with carotid plaque in The First Affiliated Hospital of Bengbu Medical College from January 2019 to December 2021 were selected as the observation group, and 59 healthy physical examination patients attending our hospital were selected as the control group during the same period.All subjects underwent carotid ultrasound examination and lipid level measurement.  Results  The IMT value of the observation group was (1.58±0.34) mm, which was significantly higher than that of the control group[(0.76±0.12) mm], and the difference was statistically significant (P < 0.05).The LDL-C value and HDL-C value of the observation group were (3.09±1.01) mmol/L and (1.18±0.37) mmol/L respectively.Compared with the LDL-C value[(2.67±0.68) mmol/L]and HDL-C value[(1.33±0.32) mmol/L]of the control group, the former was significantly higher and the latter was significantly lower, and the difference was statistically significant (all P < 0.05).However, the TC value of the observation group was (4.94±1.18) mmol/L and TG value was (1.85±0.67) mmol/L, which were higher than those of the control group[TC value was (4.69±0.76) mmol/L and TG value was (1.71±0.92) mmol/L].Although there was a certain increase, the difference was not statistically significant (all P>0.05).  Conclusion  Cardiovascular diseases are closely related to dyslipidemia and the development of atherosclerotic plaque formation.High levels of TC, TG and LDL-C lead to the thickening of arterial IMT and the development of atherosclerotic plaque.Therefore, carotid ultrasound should be performed in patients with hyperlipidemia to determine the condition of atherosclerotic plaque, which can provide some diagnostic value for the early regulation of blood lipids and active predicting of related complications.

     

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    • References(22)
  • [1]
    BOREN J, WILLIAMS K J. The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: A triumph of simplicity[J]. Curr Opin Lipidol, 2016, 27(5): 473-483. doi: 10.1097/MOL.0000000000000330
    [2]
    ALBANY C J, TREVELIN S C, GIGANTI G, et al. Getting to the heart of the matter: The role of regulatory T-Cells (Tregs) in cardiovascular disease (CVD) and atherosclerosis[J]. Front Immunol, 2019. DOI: 10.3389/fimmu.2019.02795.
    [3]
    GORDTS P L S M, ESKO J D. The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis[J]. Matrix Biol, 2018. DOI: 10.1016/j.matbio.2018.05.010.
    [4]
    CAPPELLO A R, DOLCE V, IACOPETTA D, et al. Bergamot (Citrus bergamia Risso) flavonoids and their potential benefits in human hyperlipidemia and atherosclerosis: An overview[J]. Mini Rev Med Chem, 2016, 16(8): 619-629. doi: 10.2174/1389557515666150709110222
    [5]
    高秀芳, 李勇. 《中国成人血脂异常防治指南2016修订版》更新要点解析[J]. 中华高血压杂志, 2017, 25(1): 15-18. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ201701007.htm

    GAO X F, LI Y. Analysis of the updated key points of the 2016 revised guidelines for the prevention and treatment of dyslipidemia in Chinese adults[J]. Chinese Journal of Hypertension, 2017, 25(1): 15-18. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ201701007.htm
    [6]
    GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: A systematic analysis for the global burden of disease study 2017[J]. Lancet, 2018, 392(10159): 1789-1858. doi: 10.1016/S0140-6736(18)32279-7
    [7]
    ZAMANI M, SKAGEN K, SCOTT H, et al. Advanced ultrasound methods in assessment of carotid plaque instability: A prospective multimodal study[J]. BMC Neurol, 2020, 20(1): 39. doi: 10.1186/s12883-020-1620-z
    [8]
    宋新雨, 宋俊权, 胡乐. 动脉粥样硬化与血管性认知障碍的相关性研究进展[J]. 中国临床新医学, 2021, 14(10): 1058-1062. doi: 10.3969/j.issn.1674-3806.2021.10.24

    SONG X Y, SONG J Q, HU L. Progress in research on the correlation between atherosclerosis and vascular cognitive impairment[J]. Chinese Journal of New Clinical Medicine, 2021, 14(10): 1058-1062. doi: 10.3969/j.issn.1674-3806.2021.10.24
    [9]
    MAGUIRE E M, PEARCE S W A, XIAO Q Z. Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease[J]. Vascul Pharmacol, 2019. DOI: 10.1016/j.vph.2018.08.002.
    [10]
    SEDDING D G, BOYLE E C, DEMANDT J A F, et al. Vasa vasorum angiogenesis: Key player in the initiation and progression of atherosclerosis and potential target for the treatment of cardiovascular disease[J]. Front Immunol, 2018. DOI: 10.3389/fimmu.2018.00706.
    [11]
    HUANG C W, HE Q, HUANG M W, et al. Non-invasive identification of vulnerable atherosclerotic plaques using texture analysis in ultrasound carotid elastography: An in vivo feasibility study validated by magnetic resonance imaging[J]. Ultrasound Med Biol, 2017, 43(4): 817-830. doi: 10.1016/j.ultrasmedbio.2016.12.003
    [12]
    林厚强, 钱平安. 超声测定颈动脉内中膜厚度与动脉弹性对冠心病病变程度的评估价值[J]. 海南医学院学报, 2016, 22(24): 3090-3093. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY201624044.htm

    LIN H Q, QIAN P A. Value of ultrasonic measurement of carotid intima-media thickness and arterial elasticity for assessment of coronary heart disease severity[J]. Journal of Hainan Medical University, 2016, 22(24): 3090-3093. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY201624044.htm
    [13]
    MIAO J Y, ZANG X L, CUI X L, et al. Autophagy, Hyperlipidemia, and Atherosclerosis[J]. Adv Exp Med Biol, 2020. DOI: 10.1007/978-981-15-4272-5_18.
    [14]
    FERENCE B A, GINSBERG H N, GRAHAM I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel[J]. Eur Heart J, 2017, 38(32): 2459-2472. doi: 10.1093/eurheartj/ehx144
    [15]
    BOBRYSHEV Y V, IVANOVA E A, CHISTIAKOV D A, et al. Macrophages and their role in atherosclerosis: Pathophysiology and transcriptome analysis[J]. Biomed Res Int, 2016. DOI: 10.1155/2016/9582430.
    [16]
    陈维娜, 顾翔. 超声探查颈动脉粥样硬化指标在冠心病诊疗方面的研究进展[J]. 中华老年多器官疾病杂志, 2021, 20(11): 862-865. doi: 10.11915/j.issn.1671-5403.2021.11.181

    CHEN W N, GU X. Progress in research of ultrasonic indicators for carotid atherosclerosis in diagnosis and treatment of coronary disease[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2021, 20(11): 862-865. doi: 10.11915/j.issn.1671-5403.2021.11.181
    [17]
    魏红, 于北凯, 齐立中. 小而密低密度脂蛋白胆固醇联合同型半胱氨酸对冠心病患者颈动脉斑块、颈动脉内膜中层厚度的关系及诊断价值[J]. 中国临床医生杂志, 2018, 46(4): 405-407. doi: 10.3969/j.issn.2095-8552.2018.04.010

    WEI H, YU B K, QI L Z. Relationship and diagnostic value of small dense low-density lipoprotein cholesterol combined with homocysteine on carotid plaque and carotid intima-media thickness in patients with coronary heart disease[J]. Chinese Journal for Clinicians, 2018, 46(4): 405-407. doi: 10.3969/j.issn.2095-8552.2018.04.010
    [18]
    阮敏. 血脂异常患者颈动脉超声表现和冠状动脉病变的相关性[J]. 吉林医学, 2021, 42(5): 1204-1206. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202105074.htm

    RUAN M. Correlation between carotid ultrasound findings and coronary artery disease in patients with dyslipidemia[J]. Jilin Medical Journal, 2021, 42(5): 1204-1206. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202105074.htm
    [19]
    TEN KATE G L, VAN DIJK A C, VAN DEN OORD S C H, et al. Usefulness of contrast-enhanced ultrasound for detection of carotid plaque ulceration in patients with symptomatic carotid atherosclerosis[J]. Am J Cardiol, 2013, 112(2): 292-298.
    [20]
    谢翔. 动脉粥样硬化患者甘油三酯升高的管理中国专家共识[J]. 中华全科医学, 2019, 17(5): 709-713. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201905002.htm

    XIE X. Chinese expert consensus on the management of elevated triglycerides in patients with atherosclerosis[J]. Chinese Journal of General Practice, 2019, 17(5): 709-713. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201905002.htm
    [21]
    罗燕萍. 超声诊断颈动脉粥样硬化与脑梗死的应用价值[J]. 中国继续医学教育, 2021, 13(32): 135-138. https://www.cnki.com.cn/Article/CJFDTOTAL-JXUY202132035.htm

    LUO Y P. Application value of ultrasound in diagnosis of carotid atherosclerosis and cerebral infarction[J]. China Continuing Medical Education, 2021, 13(32): 135-138. https://www.cnki.com.cn/Article/CJFDTOTAL-JXUY202132035.htm
    [22]
    李怡, 何文. 颈动脉粥样硬化易损斑块超声标志与脑血管疾病关系的研究进展[J]. 中国卒中杂志, 2021, 16(11): 1183-1188. https://www.cnki.com.cn/Article/CJFDTOTAL-ZUZH202111017.htm

    LI Y, HE W. Progress of relationship between ultrasound biomarkers of vulnerable carotid atherosclerotic plaque and cerebrovascular disease[J]. Chinese Journal of Stroke, 2021, 16(11): 1183-1188. https://www.cnki.com.cn/Article/CJFDTOTAL-ZUZH202111017.htm
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