Volume 20 Issue 9
Sep.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(9): 1477-1480
ZHU Chun-yan, HU Xi-wen, JU Xuan, SUN Ji-jun. Effectiveness of Transcranial Direct Current Stimulation Therapy Combined with Vortioxetine for patients with anhedonia depression[J]. Chinese Journal of General Practice, 2022, 20(9): 1477-1480. doi: 10.16766/j.cnki.issn.1674-4152.002627
Citation: ZHU Chun-yan, HU Xi-wen, JU Xuan, SUN Ji-jun. Effectiveness of Transcranial Direct Current Stimulation Therapy Combined with Vortioxetine for patients with anhedonia depression[J]. Chinese Journal of General Practice, 2022, 20(9): 1477-1480. doi: 10.16766/j.cnki.issn.1674-4152.002627
shu

Effectiveness of Transcranial Direct Current Stimulation Therapy Combined with Vortioxetine for patients with anhedonia depression

doi: 10.16766/j.cnki.issn.1674-4152.002627
  • 1.

    No.6 Department of Psychiatry, Hangzhou Seventh People's Hospital; Affiliated Mental Health Center of Zhejiang 310013, China

Funds:

 2021KY914

 2020KY747

  • Received Date: 2022-01-12
    Available Online: 2022-11-29
    Abstract
  •   Objective  To investigate the therapeutic effect of transcranial direct current stimulation (tDCS) therapy targeting left dorsolateral prefrontal lobe on major depressive disorder (MDD) patients with anhedonic features.  Methods  A total of 61 patients with depression treated in Hangzhou Seventh People's Hospital from June 2020 to June 2021 were selected and randomly assigned to real tDCS group (30 cases) and sham tDCS group (31 cases). The real tDCS group was treated with 2 mA tDCS, the sham tDCS group was treated with the same parameter settings. All patients were treated with vortioxetine at 10 mg/d at the same time, and both groups were treated for 2 weeks. The Hamilton Depression Scale (HAMD-17), Snaith-Hamilton Pleasure Scale (SHAPS), Dimensional Anhedonia Rating Scale (DARS) were evaluated at baseline, 1 week and 2 weeks after treatment, respectively.  Results  Before treatment, there were no significant differences in age, gender, years of education, total disease course and episodes of disease between 2 groups (all P>0.05). After treatment, SHAPS score and HAMD-17 score in the real tDCS group were lower than those before treatment (all P < 0.05), and the DARS score was higher than that before treatment (P < 0.05). After 2 weeks of treatment, the SHAPS score in the real tDCS group [(17.71±3.11) points] was lower than that in the sham tDCS group [(19.45±3.42) points], and the HAMD-17 score in the real tDCS group [(16.70±5.36) points] was also lower than that in the sham tDCS group [(20.22±4.84) points]. the DARS score in the real tDCS group [(46.27±8.75) points] was higher than that in the sham tDCS group [(39.84±9.69) points], and the difference was all statistically significant (all P < 0.05).  Conclusion  tDCS therapy targeting the left dorsolateral prefrontal cortex can effectively treat MDD patients with anhedonic features.

     

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