Volume 20 Issue 9
Sep.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(9): 1491-1494
CHEN Hai-si, GAO Jing-fang, WANG Xiao-le, HU Xi-wen. Early effects and impacts on cold executive function of repetitive transcranial magnetic stimulation combined with sertraline in first-episode adolescent depression[J]. Chinese Journal of General Practice, 2022, 20(9): 1491-1494. doi: 10.16766/j.cnki.issn.1674-4152.002631
Citation: CHEN Hai-si, GAO Jing-fang, WANG Xiao-le, HU Xi-wen. Early effects and impacts on cold executive function of repetitive transcranial magnetic stimulation combined with sertraline in first-episode adolescent depression[J]. Chinese Journal of General Practice, 2022, 20(9): 1491-1494. doi: 10.16766/j.cnki.issn.1674-4152.002631
shu

Early effects and impacts on cold executive function of repetitive transcranial magnetic stimulation combined with sertraline in first-episode adolescent depression

doi: 10.16766/j.cnki.issn.1674-4152.002631
  • 1.

    Psychosomatic Department, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310013, China

Funds:

 2020KY747

  • Received Date: 2021-07-07
    Available Online: 2022-11-29
    Abstract
  •   Objective  To explore the early effects and impacts on cold executive function of repetitive transcranial magnetic stimulation (rTMS) combined with sertraline in adolescents with first-episode major depressive disorder.  Methods  A total of 77 adolescent patients with first-episode depression from Hangzhou 7th Hospital were divided into study group (38 cases) and control group (39 cases) by random number method. The control group was treated with sertraline (25 mg/d in first week, up to 100 mg/ d in 2 weeks). The study group was given sertraline combined with rTMS (1 time/d, 5 times/ week). Depressive symptoms and cold executive function before and after treatment were evaluated using Hamilton Depression Scale (HAMD-17), children's Depression Rating Scale (CDRS-R), audiovisual integration continuous operation test (IVA-CPT) and THINC-it.  Results  The early improvement rate in the study group was 92.11% (35/38), higher than 71.79% (28/39) in the control group (P < 0.05). After 2 and 4 weeks of treatment, the HAMD-17 and CDRs-R scores of the two groups decreased compared with those before treatment, and the scores of the study group were lower than those of the control group after treatment (all P < 0.05). After 4 weeks of treatment, the attention quotient (listening, visual and full-scale) in the study group [(98.24±20.72) points, (90.00±21.97) points, (94.24±21.43) points] was higher than that in the control group [(82.62±27.71) points, (78.10±27.85) points, (80.21±24.47) points], and the difference was statistically significant (all P < 0.05). Both two groups improved statistically significant in Spotter, Symbol Check, Codebreake, and Trails (all P < 0.05). The study group showed significantly higher score in PDQ5 in THINC-it after treatment (P < 0.05).  Conclusion  Sertraline combined with rTMS can early improve the clinical symptoms and cold executive function of first-episode adolescent depression patients.

     

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