Volume 20 Issue 10
Oct.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(10): 1658-1661
KANG Hai-han, LI Fei, WU Cheng-wen, CUI Wen-jun. Effect of Mailuoning injection on blood circulation and vascular endothelium in patients with lower extremity arteriosclerosis obliterans[J]. Chinese Journal of General Practice, 2022, 20(10): 1658-1661. doi: 10.16766/j.cnki.issn.1674-4152.002672
Citation: KANG Hai-han, LI Fei, WU Cheng-wen, CUI Wen-jun. Effect of Mailuoning injection on blood circulation and vascular endothelium in patients with lower extremity arteriosclerosis obliterans[J]. Chinese Journal of General Practice, 2022, 20(10): 1658-1661. doi: 10.16766/j.cnki.issn.1674-4152.002672
shu

Effect of Mailuoning injection on blood circulation and vascular endothelium in patients with lower extremity arteriosclerosis obliterans

doi: 10.16766/j.cnki.issn.1674-4152.002672
  • 1.

    Department of Vascular Surgery, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China

Funds:

 LHGJ20190420

  • Received Date: 2021-07-15
    Available Online: 2022-11-30
    Abstract
  •   Objective  To investigate the effect of Mailuoning injection on blood circulation and vascular endothelium in lower extremity arteriosclerosis obliterans (ASO).   Methods  A total of 104 lower extremity ASO patients treated in the Second Affiliated Hospital of Zhengzhou University from January 2018 to January 2020 were enrolled and were divided into control group (52 cases) and observation group (52 cases) according to the random number table method. The control group was treated with Alprostadil injection, and the observation group was treated with Alprostadil injection combined with Mailuoning. The blood rheology indexes, adhesion factors and inflammatory factor levels of the two groups were compared before and after treatment, and the short-term clinical efficacy and adverse reactions during the treatment of the two groups were compared.   Results  No significant difference in plasma viscosity, erythrocyte stiffness index, erythrocyte aggregation index and whole blood viscosity was found between the two groups before treatment (all P>0.05). After treatment, the levels of five indicators in the two groups were lower than before treatment, and the observation group was lower in the control group (all P < 0.05). No significant differences in the levels of adhesion factor ET-1 and ICAM-1 in the two groups before treatment (all P>0.05). After treatment, the levels of ET-1 and ICAM-1 in the two groups were lower than those before treatment, and the levels in the observation group were lower than those of control group (all P < 0.05). No significant difference in serum inflammatory factors IL-6, IL-8, TNF-α and hs-CRP was found between the two groups before treatment (all P>0.05). After treatment, the levels of four indicators in the two groups were lower than those before treatment, and the observation group had lower levels than the control group (all P < 0.05). The effective rate of the observation group was higher than that of the control group (92.31% vs. 76.91%, χ2=4.727, P=0.030). No serious adverse reactions were observed in the two groups, and the total adverse reaction rate (11.45% vs. 9.62%) was not statistically significant (χ2=0.102, P=0.749).   Conclusion  Alprostadil combined with Mailuoning injection in the treatment of lower extremity ASO can improve patient ' s hemorheological indexes, regulate the levels of adhesion factors and inflammatory factors without increasing adverse reactions and have high safety and significant efficacy.

     

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