Volume 20 Issue 10
Oct.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(10): 1662-1665
GAI Mei-hua, FU Yan-ping, JIN Ai-xiang, YAO Hui-ping. Influence on levels of melatonin and oxidative stress in critically ill patients with AECOPD treated by different ways of light[J]. Chinese Journal of General Practice, 2022, 20(10): 1662-1665. doi: 10.16766/j.cnki.issn.1674-4152.002673
Citation: GAI Mei-hua, FU Yan-ping, JIN Ai-xiang, YAO Hui-ping. Influence on levels of melatonin and oxidative stress in critically ill patients with AECOPD treated by different ways of light[J]. Chinese Journal of General Practice, 2022, 20(10): 1662-1665. doi: 10.16766/j.cnki.issn.1674-4152.002673
shu

Influence on levels of melatonin and oxidative stress in critically ill patients with AECOPD treated by different ways of light

doi: 10.16766/j.cnki.issn.1674-4152.002673
  • 1.

    Department of Head and Neck Thyroid Surgery, Zhejiang Provincial People ' s Hospital/People's Hospital Affiliated Hangzhou Medical College, Hangzhou, Zhejiang 310014, China

Funds:

 2020KY444

  • Received Date: 2021-08-16
    Available Online: 2022-11-30
    Abstract
  •   Objective  To discuss the influence on levels of melatonin (Mel) and oxidative stress in critically ill patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated by different ways of light.   Methods  One hundred patients with AECOPD admitted to the Intensive Care Unit (ICU) of Zhejiang Province People ' s Hospital from July 2019 to December 2020 were selected as study subjects and divided into the control group (n=48) and observation group (n=52) according to random number table. The patients of control group were given 24-hour illumination, while the patients of observation group were given intermittent light way. The levels of serum Mel and urine 6-sulfonic melatonin (6-SMT), malondialdehyde (MDA) and superoxide dismutase (SOD) in bronchoalveolar lavage fluid (BALF) were measured, and statistical analysis were carried out.   Results  The levels of serum Mel (7 a.m. and 10 p.m.) were (29.6±5.8) pg/mL, (26.7±6.4) pg/mL and (50.8±8.5) pg/mL, (46.7±9.1) pg/mL respectively at 5 days after admission. The levels of serum Mel (7 a.m. and 10 p.m.) were (35.3±8.2) pg/mL, (24.5±5.7) pg/mL and (55.6±6.6) pg/mL, (44.5±7.5) pg/mL respectively at 10 days after admission. Compared with the control group, the levels of serum Mel (7 a.m. and 10 p.m.) in the observation group showed a gradually increasing trend (all P < 0.05). The levels of urine 6-SMT (7 a.m. and 10 p.m.) in the two groups showed a similar trend. In the observation group, the level of MDA in BALF gradually decreased while the level of SOD gradually increased (all P < 0.05). The success rate of removing ventilator of the observation group was obviously higher than that of the control group, while ICU stay time, the incidence of MODS and 28-day mortality were lower than those of the control group (all P < 0.05).   Conclusion  For critically ill patients with AECOPD, intermittent illumination can obviously increase the level of melatonin and its metabolites in the body, improve the ability of resistance to oxidative stress and improve prognosis.

     

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