Volume 20 Issue 10
Oct.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(10): 1700-1703
HE Run-hua, ZHAN Lei, SONG En-xue, WEI Bing, LING Lin. Expression of NLRC5 in cervical cancer and the correlation with the patients ' survival prognosis[J]. Chinese Journal of General Practice, 2022, 20(10): 1700-1703. doi: 10.16766/j.cnki.issn.1674-4152.002683
Citation: HE Run-hua, ZHAN Lei, SONG En-xue, WEI Bing, LING Lin. Expression of NLRC5 in cervical cancer and the correlation with the patients ' survival prognosis[J]. Chinese Journal of General Practice, 2022, 20(10): 1700-1703. doi: 10.16766/j.cnki.issn.1674-4152.002683
shu

Expression of NLRC5 in cervical cancer and the correlation with the patients ' survival prognosis

doi: 10.16766/j.cnki.issn.1674-4152.002683

  • Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China

Funds:

 81802586

 2019xkj040

  • Received Date: 2021-10-16
    Available Online: 2022-11-30
    Abstract
  •   Objective  To investigate the correlation between the expression of NLRC5 (NOD-like receptor family caspase recruitment domain family-containing 5) in cervical cancer tissue and paracancerous tissue and the prognosis of cervical cancer patients.  Methods  A total of 60 patients with cervical cancer who were diagnosed and treated in the Second Affiliated Hospital of Anhui Medical University from January 2013 to June 2016 were selected. The cancer tissues and paracancerous tissues of cervical cancer surgery were collected and detected by immunohistochemistry. The expression of NLRC5 in cervical cancer tissues and paracancerous tissues was analyzed, and the correlation between the expression of NLRC5 and the prognosis of cervical cancer patients was analyzed.  Results  The positive expression of NLRC5 in cervical cancer tissues was lower than that in paracancerous tissues [15(25.00)% vs. 50(83.33%), P < 0.05)]. The expression of NLRC5 in cervical cancer tissue and the clinicopathological characteristics of patients were analyzed, and it was found that the negative expression of NLRC5 was correlated with the depth of invasion and tumor size of cervical cancer (χ2=11.769, 5.926, all P < 0.05). The expression of NLRC5 was not correlated with age, pathological type, lymph node metastasis (all P>0.05). The Kaplan-Meier curve of survival and prognosis of cervical cancer was drawn. It was found that the survival time of patients with negative NLRC5 expression were shorter than those with positive expression (P < 0.05). Univariate or Cox multivariate analysis was performed on the prognostic factors of cervical cancer, and it was found that the negative expression of NLRC5, lymphatic metastasis and depth of invasion were independent risk factors for the prognosis of cervical cancer (all P < 0.05).  Conclusion  Compared with paracancerous tissues, NLRC5 shows a low expression pattern in cervical cancer tissues. Meanwhile, the negative expression of NLRC5 is an independent risk factor affecting the prognosis of cervical cancer patients. This finding may be used for the diagnosis and treatment of cervical cancer.

     

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    • References(16)
  • [1]
    张慧慧, 王蓓蓓, 张献文, 等. 伴有盆腔淋巴结转移的宫颈癌新辅助化疗联合放化疗临床疗效及预后因素分析[J]. 中华全科医学, 2021, 19(11): 1823-1826, 1839. doi: 10.16766/j.cnki.issn.1674-4152.002176

    ZHANG H H, WANG B B, ZHANG X W, et al. Treatment effect and analysis of prognostic factors of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy for advanced cervical cancer with pelvic lymph node metastasis[J]. Chinese Journal of General Practice, 2021, 19(11): 1823-1826, 1839. doi: 10.16766/j.cnki.issn.1674-4152.002176
    [2]
    张娟, 李娜娜, 陈蕊, 等. TSHR、HPV16 E6蛋白在老年宫颈癌组织中表达及与疾病发生发展的关系[J]. 中国老年学杂志, 2021, 41(5): 963-966. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202105024.htm

    ZHANG J, LI N N, CHEN R, et al. Expressions of TSHR, HPV16 E6 in cervical cancer tissue from elderly patients and the relationship between the expressions and the development of disease[J]. Chinese Journal of Gerontology, 2021, 41(5): 963-966. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202105024.htm
    [3]
    TANG F, XU Y D, ZHAO B. NLRC5: New cancer buster?[J]. Mol Biol Rep, 2020, 47(3): 2265-2277. doi: 10.1007/s11033-020-05253-5
    [4]
    WU Y T, SHI T L, LI J. NLRC5: A paradigm for NLRs in immunological and inflammatory reaction[J]. Cancer Lett, 2019, 451(1): 92-99.
    [5]
    史于传. NLRC5通过激活卵巢癌细胞PI3K/AKT信号通路促进细胞增殖、迁移和侵袭[D]. 合肥: 安徽医科大学, 2021.

    SHI Y C. NLRC5 promotes cell proliferation, migration and invasion by activating PI3K/AKT signaling pathway in ovarian cancer cells[D]. Hefei: Anhui Medical University, 2021.
    [6]
    冯明月, 闫萍. 宫颈上皮内瘤变诊治现状[J]. 河北医科大学学报, 2020, 41(4): 480-483. doi: 10.3969/j.issn.1007-3205.2020.04.026

    FENG M Y, YAN P. Current status of diagnosis and treatment of cervical intraepithelial neoplasia[J]. Journal of Hebei Medical University, 2020, 41(4): 480-483. doi: 10.3969/j.issn.1007-3205.2020.04.026
    [7]
    赵小迎, 郑胡忠, 金纬纬, 等. 宫颈癌临床病理特征与盆腔淋巴结转移的相关性分析[J]. 中华全科医学, 2019, 17(3): 430-432. doi: 10.16766/j.cnki.issn.1674-4152.000700

    ZHAO X Y, ZHENG H Z, JIN W W, et al. Correlation between clinicopathological features and pelvic lymph node metastasis in cervical cancer[J]. Chinese Journal of General Practice, 2019, 17(3): 430-432. doi: 10.16766/j.cnki.issn.1674-4152.000700
    [8]
    蒋芳, 向阳. 早期宫颈癌微创手术的现状与未来[J]. 中国妇产科临床杂志, 2021, 22(2): 113-115. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC202102002.htm

    JIANG F, XIANG Y. Minimally invasive surgery for early stage cervical cancer: current status and the future[J]. Chinese Journal of Clinical Obstetrics and Gynecology, 2021, 22(2): 113-115. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC202102002.htm
    [9]
    SCHEFF N N, SALOMAN J L. Neuroimmunology of cancer and associated symptomology[J]. Immunol Cell Biol, 2021, 99(9): 949-61. doi: 10.1111/imcb.12496
    [10]
    LI Y X, CHANG J Y, HE M Y, et al. Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) predict clinical outcome in patients with stage ⅡB cervical cancer[J]. J Oncol, 2021, 8(9): 1-14.
    [11]
    LAVINIA D, ALESSANDRO T, PAOLO A, et al. Inflammatory biomarkers as promising predictors of prognosis in cervical cancer patients[J]. Oncology, 2021, 99(9): 571-579.
    [12]
    ZHANG Z, SUN Y H, CHEN X. NLRC5 alleviated OGD/R-induced PC12-cell injury by inhibiting activation of the TLR4/MyD88/NF-κB pathway[J]. J Int Med Res, 2020, 48(8): 1-12
    [13]
    王媛媛. NLRC5通过NF-κB与p38 MAPK通路调控肺泡巨噬细胞炎症因子分泌的机制研究[D]. 合肥: 安徽医科大学, 2018.

    WANG Y Y. NLRC5 regulates the secretion of inflammatory cytokines in alveolar macrophages through NF-κB and p38 MAPK pathway[D]. Hefei: Anhui Medical University, 2018.
    [14]
    邵帅, 朱清, 刘洁. Shh信号通路对宫颈癌细胞增殖与凋亡影响的机制研究[J]. 海南医学, 2021, 32(21): 2721-2725. https://www.cnki.com.cn/Article/CJFDTOTAL-HAIN202121001.htm

    SHAO S, ZHU Q, LIU J. Research on the mechanism of Sonic hedgehog signaling pathway on the proliferation and apoptosis of Hela cells[J]. Hainan Medical Journal, 2021, 32(21): 2721-2725. https://www.cnki.com.cn/Article/CJFDTOTAL-HAIN202121001.htm
    [15]
    汪欢, 俞广进, 熊奇如. 肝细胞癌患者中NLRC5的表达及其临床意义[J]. 肝胆外科杂志, 2018, 26(2): 149-153. https://www.cnki.com.cn/Article/CJFDTOTAL-GDWZ201802022.htm

    WANG H, YU G J, XIONG Q R. Expression of NLRC5 in hepatocellular cacinoma and its clinical significance[J]. Journal of Hepatobiliary Surgery. 2018, 26(2): 149-153. https://www.cnki.com.cn/Article/CJFDTOTAL-GDWZ201802022.htm
    [16]
    王琴. NLRC5在透明细胞肾细胞癌中的功能与机制研究[D]. 合肥: 安徽医科大学, 2019.

    WANG Q. Function and mechanism of NLRC5 in clear cell renal cell carcinoma[D]. Hefei: Anhui Medical University, 2019.
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