Volume 20 Issue 11
Nov.  2022
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(11): 1848-1851
TIAN Xue, HUANG Liu, YAO Jing-qing, LI Yun-tao. Correlation analysis between serum Lp-PLA2 level and carotid atherosclerotic plaque[J]. Chinese Journal of General Practice, 2022, 20(11): 1848-1851. doi: 10.16766/j.cnki.issn.1674-4152.002717
Citation: TIAN Xue, HUANG Liu, YAO Jing-qing, LI Yun-tao. Correlation analysis between serum Lp-PLA2 level and carotid atherosclerotic plaque[J]. Chinese Journal of General Practice, 2022, 20(11): 1848-1851. doi: 10.16766/j.cnki.issn.1674-4152.002717
shu

Correlation analysis between serum Lp-PLA2 level and carotid atherosclerotic plaque

doi: 10.16766/j.cnki.issn.1674-4152.002717
  • 1.

    Department of Neurology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China

Funds:

 B2-20170304-02

 QNRC2016677

 SPOCYB201913

  • Received Date: 2022-01-17
    Available Online: 2022-12-30
    Abstract
  •   Objective  To explore the correlation between lipoprotein associated phospholipase A2 (Lp-PLA2) and carotid atherosclerotic plaque.  Methods  A total of 1 018 patients who underwent carotid artery ultrasound and Lp-PLA2 detection from June 2019 to December 2020 in the Second Affiliated Hospital of Nanjing Medical University were selected. Based on the test results, patients were divided into (1) non-carotid plaque group (31 cases), stable group (376 cases) and unstable group (611 cases); (2) non-carotid plaque group (31 cases), unilateral group (324 cases) and bilateral group (663 cases); (3) no stenosis group (31 cases), mild (932 cases), moderate (26 cases) and severe carotid stenosis (29 cases). The total plaque area, stable plaque area, and unstable plaque area of all patients were calculated. The difference of Lp-PLA2 level among groups and the correlation of plaque area were analyzed.  Results  Compared with the non-plaque group [139.00 (96.00, 193.00) ng/mL], the Lp-PLA2 level in the unstable plaque group [179.00 (123.00, 281.00) ng/mL] and the bilateral plaque group [181.00 (120.00, 279.00) ng/mL] were significantly increased (all P < 0.05). The level of Lp-PLA2 in patients without carotid stenosis and with mild carotid stenosis were significantly different from that in patients with moderate and severe carotid stenosis (all P < 0.01). Lp-PLA2 was positively correlated with total plaque area and unstable plaque area (all P < 0.05). Lp-PLA2 had high diagnostic value for moderate and severe carotid artery stenosis (AUC=0.710, sensitivity was 43.6%, specificity was 89.7%, P < 0.001, 95% CI: 0.631-0.789).  Conclusion  Lp-PLA2 is significantly correlated with carotid plaque stability, vascular stenosis, bilateral plaque formation and plaque area, especially unstable plaque area, which can promote the formation and development of carotid atherosclerotic plaque. Lp-PLA2 has high diagnostic value for moderate and severe carotid stenosis, and may be a good indicator for large-scale clinical screening.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    王亚楠, 吴思缈, 刘鸣. 中国脑卒中15年变化趋势和特点[J]. 华西医学, 2021, 36(6): 803-807. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYX202106017.htm

    WANG Y N, WU S M, LIU M. Temporal trends and characteristics of stroke in China in the past 15 years[J]. West China Medical Journal, 2021, 36(6): 803-807. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYX202106017.htm
    [2]
    WU S M, WU B, LIU M, et al. Stroke in China: Advances and challenges in epidemiology, prevention, and management[J]. Lancet Neurol, 2019, 18(4): 394-405. doi: 10.1016/S1474-4422(18)30500-3
    [3]
    MESCHIA J F, BUSHNELL C, BODEN-ALBALA B, et al. Guidelines for the primary prevention of stroke: A statement for healthcare professionals from the American Heart Association/American Stroke Association[J]. Stroke, 2014, 45(12): 3754-3832. doi: 10.1161/STR.0000000000000046
    [4]
    STAFFORINI D M. Plasma PAF-AH (PLA2G7): Biochemical properties, association with LDLs and HDLs, and regulation of expression[J]. Enzymes, 2015, 38: 71-93.
    [5]
    CAO J, YAN P, ZHOU Y J, et al. Clinical utility of the serum level of lipoprotein-related phospholipase A2 in acute ischemic stroke with cerebral artery stenosis[J]. Front Neurol, 2021, 12: 642483. DOI: 10.3389/fneur.2021.642483.
    [6]
    李振洲, 邵玉凤, 陈胜华, 等. 颈动脉斑块稳定性超声评估与血浆脂蛋白相关磷脂酶A2水平的相关性研究[J]. 中国临床医学影像杂志, 2019, 30(3): 166-168, 173. https://www.cnki.com.cn/Article/CJFDTOTAL-LYYX201903007.htm

    LI Z Z, SHAO Y F, CHEN S H, et al. Correlation between stability of carotid plaque evaluated by ultrasound and the level of plasma Lp-PLA2[J]. Journal of China Clinic Medical Imaging, 2019, 30(3): 166-168, 173. https://www.cnki.com.cn/Article/CJFDTOTAL-LYYX201903007.htm
    [7]
    张瑾, 潘凤华, 吴晋. 脑梗死患者脂蛋白相关磷脂酶A2水平及其与颈动脉斑块稳定性的相关性研究[J]. 系统医学, 2018, 3(14): 1-3. https://www.cnki.com.cn/Article/CJFDTOTAL-XTYX201814001.htm

    ZHANG J, PAN F H, WU J. Study on Correlation between the Lipoprotein Associated Phospholipase A2 and Stability of Carotid Artery Plaque of Patients with Cerebral Infraction[J]. Systems Medicine, 2018, 3(14): 1-3. https://www.cnki.com.cn/Article/CJFDTOTAL-XTYX201814001.htm
    [8]
    郝泽林, 吴建跃, 滕振飞, 等. 急性脑梗死患者血清学指标与神经功能缺损和脑梗死体积及颈动脉斑块性质的相关性研究[J]. 中华全科医学, 2020, 18(11): 1803-1806. doi: 10.16766/j.cnki.issn.1674-4152.001623

    HAO Z L, WU J Y, TENG Z F, et al. Correlation of hs-CRP, MMP-9 and Lp-PLA2 with neurological deficit, cerebral infarction volume and carotid plaque properties in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2020, 18(11): 1803-1806. doi: 10.16766/j.cnki.issn.1674-4152.001623
    [9]
    中国医师协会神经内科医师分会神经超声专业委员会, 中华医学会神经病学分会神经影像协作组. 中国神经超声的操作规范(三)[J]. 中华医学杂志, 2017, 97(43): 3361-3370. doi: 10.3760/cma.j.issn.0376-2491.2017.43.001

    Neuroultrasound Professional Committee of Chinese Medical Doctor Association, Neuroimaging Collaborative Group of Chinese Society of Neurology. Chinese Code of practice for neuroultrasound(3)[J]. National Medical Journal of China, 2017, 97(43): 3361-3370. doi: 10.3760/cma.j.issn.0376-2491.2017.43.001
    [10]
    LIU H M, YAN Y, WANG Y X, et al. Association between high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2 and carotid atherosclerosis: A cross-sectional study[J]. J Cell Mol Med, 2018, 22(10): 5145-5150.
    [11]
    HUANG X Y, WANG A X, LIU X X, et al. Association between high sensitivity C-reactive protein and prevalence of asymptomatic carotid artery stenosis[J]. Atherosclerosis, 2016, 246: 44-49.
    [12]
    SASAI M, ISO Y, MIZUKAMI T, et al. Potential contribution of the hepcidin-macrophage axis to plaque vulnerability in acute myocardial infarction in human[J]. Int J Cardiol, 2017, 227: 114-121.
    [13]
    DENNIS E A, JIAN C, HSU Y H, et al. Phospholipase A2 enzymes: Physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention[J]. Chem Rev, 2011, 111(10): 6130-6185.
    [14]
    HUANG F B, WANG K, SHEN J H. Lipoprotein-associated phospholipase A2: The story continues[J]. Med Res Rev, 2020, 40(1): 79-134.
    [15]
    LIANG T, WANG S C, ZHANG D T, et al. Evaluation of lipoprotein-associated phospholipase A2, serum amyloid A, and fibrinogen as diagnostic biomarkers for patients with acute cerebral infarction[J]. J Clin Lab Anal, 2020, 34(3): e23084. DOI: 10.1002/jcla.23084.
    [16]
    陆强彬, 陆梦茹, 朱祖福, 等. 脂蛋白相关磷脂酶A2、脂蛋白(a)与脑梗死进展及头颈部血管狭窄的相关性[J]. 中国动脉硬化杂志, 2018, 26(12): 1270-1272, 1290. https://www.cnki.com.cn/Article/CJFDTOTAL-KDYZ201812016.htm

    LU Q B, LU M R, ZHU Z F, et al. The correlation of lipoprotein associated phospholipase A2 and lipoprotein(a) with progress of cerebral infarction and the vascular stenosis of intracranial and external[J]. Chinese Journal of Arteriosclerosis, 2018, 26(12): 1270-1272, 1290. https://www.cnki.com.cn/Article/CJFDTOTAL-KDYZ201812016.htm
    [17]
    ALSULAIMANI S, GARDENER H, ELKIND M, et al. Elevated homocysteine and carotid plaque area and densitometry in the Northern Manhattan Study[J]. Stroke, 2013, 44(2): 457-461.
    [18]
    WEI L L, KE Z Y, ZHAO Y, et al. The elevated lipoprotein-associated phospholipase A2 activity is associated with the occurrence and recurrence of acute cerebral infarction[J]. Neuroreport, 2017, 28(6): 325-330.
    [19]
    王亚飞, 李惠勉. 动脉粥样硬化血栓形成性脑梗死患者血清Lp-PLA2水平变化及其意义[J]. 山东医药, 2018, 58(11): 72-74. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY201811022.htm

    WANG Y F, LI H M. Changes and significance of serum LP-PLA2 levels in patients with atherosclerotic thrombotic cerebral infarction[J]. Shandong Medical Journal, 2018, 58(11): 72-74. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY201811022.htm
    [20]
    STEFANO A D, MA NN UCCI L, TAMBURI F, et al. Lp-PLA2, a new biomarker of vascular disorders in metabolic diseases[J]. Int J Immunopathol Pharmacol, 2019, 33: 205873841982715. DOI: 10.1177/2058738419827154.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (138) PDF downloads(8) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return