Volume 20 Issue 11
Nov.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(11): 1878-1880
JIA Wen-ting, WANG Ling-zhi, LIU Min-min, ZHANG Zhen. Clinical analysis of coagulation function and platelet count in neonates of different gestational ages[J]. Chinese Journal of General Practice, 2022, 20(11): 1878-1880. doi: 10.16766/j.cnki.issn.1674-4152.002725
Citation: JIA Wen-ting, WANG Ling-zhi, LIU Min-min, ZHANG Zhen. Clinical analysis of coagulation function and platelet count in neonates of different gestational ages[J]. Chinese Journal of General Practice, 2022, 20(11): 1878-1880. doi: 10.16766/j.cnki.issn.1674-4152.002725
shu

Clinical analysis of coagulation function and platelet count in neonates of different gestational ages

doi: 10.16766/j.cnki.issn.1674-4152.002725
  • 1.

    Department of Pediatrics, the Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233040, China

Funds:

 KJ2021A0800

 BYKY2019155ZD

  • Received Date: 2022-06-18
    Available Online: 2022-12-30
    Abstract
  •   Objective  To explore the coagulation function and platelets of neonates of different gestational ages after birth, and to provide a basis for the diagnosis and treatment of neonates and the evaluation of bleeding tendency.  Methods  A total of 89 neonates admitted to the Department of Pediatrics of the Second Affiliated Hospital of Bengbu Medical College from October 2019 to April 2022 were selected. Based on the gestational age, there were 11 cases of early preterm infants (28-31+6 weeks), 17 cases of moderately preterm infants (32-33+6 weeks) and 26 cases of late preterm infants (34-36+6 weeks). Meanwhile, there were a total of 35 full-term infants (gestational age 37-41+6 weeks). The platelet (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), D-dimer (D-D) and international normalized ratio (INR) were measured within 6 hours after admission. In addition, the clinical data, detection indicators, incidence of abnormal coagulation function and incidence of bleeding were compared among the four groups to compare the incidence of disseminated intravascular coagulation (DIC) in preterm infants and full-term infants.  Results  Serum PT, APTT, TT, D-D and INR of early and moderately preterm infants were higher than those of late preterm infants and full-term infants, and the serum FIB was lower than that of late preterm and full-term infants. Meanwhile, PLT in early preterm infants was lower than that in the other three groups (all P < 0.05). The incidence of bleeding in early, middle, late preterm and full-term infants were 72.73% (8/11), 52.94% (9/17), 30.77% (8/26) and 25.71% (9/35), respectively. Moreover, the incidences of abnormal coagulation function were 81.82% (9/11), 70.59% (12/17), 53.85% (14/26) and 37.14% (13/35), respectively. Furthermore, the incidences of bleeding and abnormal coagulation function in early and moderately preterm infants were higher than those in late preterm infants and full-term infants. The incidence of DIC in preterm infants was 22.22% (12/54), which was higher than that in full-term infants at 2.86% (1/35).  Conclusion  The lower the gestational age, the more imperfect the coagulation function, and the higher the incidence of bleeding, coagulation dysfunction and DIC.

     

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