Volume 20 Issue 11
Nov.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(11): 1884-1888
CHU An-zhen, ZHANG Lan. The predictive value of systemic immune-inflammation index for intravenous immunoglobulin resistance in children with Kawasaki disease[J]. Chinese Journal of General Practice, 2022, 20(11): 1884-1888. doi: 10.16766/j.cnki.issn.1674-4152.002727
Citation: CHU An-zhen, ZHANG Lan. The predictive value of systemic immune-inflammation index for intravenous immunoglobulin resistance in children with Kawasaki disease[J]. Chinese Journal of General Practice, 2022, 20(11): 1884-1888. doi: 10.16766/j.cnki.issn.1674-4152.002727
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The predictive value of systemic immune-inflammation index for intravenous immunoglobulin resistance in children with Kawasaki disease

doi: 10.16766/j.cnki.issn.1674-4152.002727

  • Department of Pediatrics, the First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, China

Funds:

 2021jyxm1760

  • Received Date: 2022-05-06
    Available Online: 2022-12-30
    Abstract
  •   Objective  To evaluate the predictive value of systemic immune-inflammation index (SII) for intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD).  Methods  A total of 445 hospitalized children diagnosed with KD and treated with IVIG in the First Affiliated Hospital of University of Science and Technology of China from January 2018 to March 2022 were retrospectively analyzed. According to the presence of IVIG resistance, they were divided into IVIG resistance group and IVIG sensitive group. Stratified analysis was performed according to platelet value. The differences of inflammatory indexes between each group were compared and binary logistic regression was used to analyze the correlation between each inflammatory index and IVIG-resistance in children with KD. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of each inflammatory index for IVIG-resistance in children with KD.  Results  For all children with KD, inflammatory indexes including N, NLR, PLR, SII, and CRP of the IVIG-resistant group were higher than those of the IVIG-sensitive group (all P < 0.05), and L was lower (P < 0.05). For thrombocytopenia KD children, there was no statistical difference in the values of each inflammatory indexes. For non-thrombocytopenia KD children, the levels of N, NLR and SII of the IVIG-resistant group were higher than those of the IVIG-sensitive group (all P < 0.05). Logistic regression analysis showed that both NLR and SII were independent risk factors for predicting IVIG resistance. ROC curve analysis showed that the sensitivity of NLR for predicting IVIG-resistance in allover the KD children was 55%, and the specificity was 67%. The sensitivity of SII for predicting IVIG-resistance in non-thrombocytopenic KD children was 56%, and the specificity was 64%.  Conclusion  NLR has a strong predictive ability for IVIG-resistance in allover children with KD, and SII has a strong predictive ability for IVIG-resistance in non-thrombocytopenic KD children.

     

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