Volume 20 Issue 11
Nov.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(11): 1889-1892
ZHAO Jing-li, ZHAO Li-li, CHEN Pu, DING Xian-chun. Efficacy of Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets in the treatment of infantile diarrhea predominant irritable bowel syndrome[J]. Chinese Journal of General Practice, 2022, 20(11): 1889-1892. doi: 10.16766/j.cnki.issn.1674-4152.002728
Citation: ZHAO Jing-li, ZHAO Li-li, CHEN Pu, DING Xian-chun. Efficacy of Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets in the treatment of infantile diarrhea predominant irritable bowel syndrome[J]. Chinese Journal of General Practice, 2022, 20(11): 1889-1892. doi: 10.16766/j.cnki.issn.1674-4152.002728
shu

Efficacy of Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets in the treatment of infantile diarrhea predominant irritable bowel syndrome

doi: 10.16766/j.cnki.issn.1674-4152.002728

  • Department of Pediatrics, Nanyang Central Hospital, Nanyang, Henan 473000, China

Funds:

 172102310153

  • Received Date: 2022-01-12
    Available Online: 2022-12-30
    Abstract
  •   Objective  To investigate the efficacy of Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets in the treatment of infantile diarrhoea predominant irritable bowel syndrome (IBS).  Methods  A total of 104 children with diarrhoea-predominant IBS in Nanyang Central Hospital from October 2018 to October 2020 were selected and equally divided into control and observation groups by the random number table. The control group was treated with bifidobacterium quadruple viable tablets, and the observation group was treated with Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets. The total effective rate and adverse reactions were compared between the two groups. The traditional chinese medcine syndrome score, T lymphocyte subsets and brain gut peptide indexes of the two groups were compared before and after treatment.  Results  The total effective rate of the observation group was 90.38% (47/52), which was significantly higher than 75.00% (39/52) of the control group (χ2=4.299, P=0.038). After treatment, the syndrome scores of diarrhea [(1.26±0.32) points vs. (1.87±0.39) points], abdominal pain [(1.28±0.37) points vs. (1.94±0.43) points], fullness in both flanks [(0.74±0.16) points vs. (1.07±0.24) points], nausea [(0.54±0.13) points vs. (0.75±0.19) points], nausea [(0.47±0.18) points vs. (0.82±0.27) points] in the observation group were significantly lower than those of the control group (all P < 0.05). After treatment, the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group (all P < 0.05); the level of CD8+ in the observation group was lower than that in the control group (t=4.418, P < 0.05). After treatment, the levels of substance P, neurotensin, motilin and gastrin in the observation group were higher than those in the control group (all P < 0.05). No obvious adverse reaction was found in the two groups.  Conclusion  Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets effectively treat infantile-diarrhoea-predominant IBS, can significantly alleviate clinical symptoms and regulates T lymphocyte subsets and brain gut peptide levels.

     

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