Progress on the relationship between gut microbiota and female reproductive diseases

XIE Duo; ZHANG Ying; ZHANG Wan-lin

doi:10.16766/j.cnki.issn.1674-4152.002737

Volume 20 Issue 11

Nov. 2022

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XIE Duo, ZHANG Ying, ZHANG Wan-lin. Progress on the relationship between gut microbiota and female reproductive diseases[J]. Chinese Journal of General Practice, 2022, 20(11): 1925-1929. doi: 10.16766/j.cnki.issn.1674-4152.002737

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XIE Duo, ZHANG Ying, ZHANG Wan-lin. Progress on the relationship between gut microbiota and female reproductive diseases[J]. Chinese Journal of General Practice, 2022, 20(11): 1925-1929. doi: 10.16766/j.cnki.issn.1674-4152.002737

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Progress on the relationship between gut microbiota and female reproductive diseases

doi: 10.16766/j.cnki.issn.1674-4152.002737

XIE Duo¹
, ZHANG Ying¹
, ZHANG Wan-lin^{2
,
,}

1.
Department of Obstetrics and Gynecology, Xijing 986 Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710054, China

Funds:

2020JQ-456

Received Date: 2022-07-21
Available Online: 2022-12-30

Abstract

Abstract

The formation and proliferation of gut microbiota begin at birth, and its composition changes mainly depending on genetic, nutritional and environmental factors. There are more than thousands of bacteria in the human intestines which are highly diversified. With the development of high-throughput sequencing technology, bioinformatics and culturomics, researchers can deeply explore the composition of the microbiota and their functions. At present, the study on the correlation between gut microbiota and human diseases is booming. Gut microbiota plays an important role in human physiology, metabolism, nutrition and immune function. The delicate balance between gut microbiota and host affects the development of different diseases. An increasing number of studies have focused on the relationship between gut microbiota changes and female reproductive diseases. From animal model research to a human study, various results have shown that the diversity of gut microbiota, the change of species of bacteria abundance and the imbalance of some bacteria proportion, are closely related to female reproductive diseases, such as polycystic ovary syndrome, endometriosis, pregnancy complications and adverse pregnancy outcomes, however, the mechanism is still limited. Targeting specific gut microbiota or its metabolites, results have initially shown effects in the clinical study of diagnosis and treatment of female reproductive-related diseases. Therefore, further mechanism research is needed to clarify the causal relationship between gut microbiota and female reproductive diseases and design more rigorous clinical trials to clarify the standards of effective treatment to provide more basis for the application of gut microbiota in disease prevention, diagnosis and treatment. Thus, this article reviews the research progress on the relationship between intestinal flora and polycystic ovary syndrome, endometriosis and recurrent abortion.
- Gut microbiota,
- Polycystic ovary syndrome,
- Endometriosis,
- Recurrent spontaneous abortion

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References(50)

References

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Progress on the relationship between gut microbiota and female reproductive diseases

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Progress on the relationship between gut microbiota and female reproductive diseases

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