Volume 20 Issue 11
Nov.  2022
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WU Xue-mei, WANG Hai-yan. Investigation and risk factors analysis of comorbid anxiety and depression in patients with epilepsy[J]. Chinese Journal of General Practice, 2022, 20(11): 1969-1972. doi: 10.16766/j.cnki.issn.1674-4152.002748
Citation: WU Xue-mei, WANG Hai-yan. Investigation and risk factors analysis of comorbid anxiety and depression in patients with epilepsy[J]. Chinese Journal of General Practice, 2022, 20(11): 1969-1972. doi: 10.16766/j.cnki.issn.1674-4152.002748
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Investigation and risk factors analysis of comorbid anxiety and depression in patients with epilepsy

doi: 10.16766/j.cnki.issn.1674-4152.002748

  • Department of Psychiatry, Affiliated Mental Health Center Zhejiang University School of Medical, the Seventh People' s Hospital of Hangzhou City, Hangzhou, Zhejiang 310013, China

Funds:

 2020KY746

  • Received Date: 2021-12-09
    Available Online: 2022-12-30
    Abstract
  •   Objective  To investigate the status of comorbid anxiety and depression in patients with epilepsy and analyse the risk factors of comorbid anxiety and depression.  Methods  A total of 285 patients with epilepsy treated in the Seventh People' s Hospital of Hangzhou City from February 2019 to February 2021 were recruited in the stduy. The Chinese version of generalised anxiety disorder-7 (GAD-7) and epilepsy with neurological disorders and depression inventory for epilepsy (NDDI-E) were used in surveying epileptic patients with anxiety and depression status. Single-factor analysis was used in epileptic patients with anxiety, depression and related factors, and then multi-factor logistic regression analysis was performed in examining the independent risk factors of comorbid anxiety and depression.  Results  Among the 285 epilepsy patients, 47 patients (16.49%) suffered from anxiety, 73 patients (25.61%) suffered from depression and 42 patients (14.74%) suffered from both. Multivariate Logistic regression analysis showed that long disease duration, types of oral drugs, seizure frequency of >2 times per month and seizure type with focal disturbance of consciousness were independent risk factors for comorbid anxiety in epileptic patients (ORduration=1.514; ORtypes of oral drugs=1.719; ORseizure frequency=6.455; ORtype of seizures=3.083); multiple types of oral drugs, seizure frequency >2 times/month and seizure type with focal disturbance of consciousness were independent risk factors for comorbid depression in epileptic patients (ORtype of oral drug=1.773; ORseizure frequency=5.457; ORseizure type=2.399); seizure frequency of >2 times/month, focal with the disturbance of consciousness seizures were independent risk factors for comorbid anxiety and depression in epilepsy patients (ORseizure frequency=7.205; ORseizure type=3.958).  Conclusion  The prevalence of comorbid anxiety and depression in epileptic patients is high. Clinical measures should be taken according to risk factors, and psychological counselling and counselling should be carried out to reduce the incidence of anxiety and depression in patients with epilepsy.

     

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