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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(12): 2006-2009
ZHANG Fang, CHEN Guo-fan, REN Kai-han, WANG Ming-wei. Effects of Shexiang Baoxin Pills on cardiac function, ventricular remodeling and vascular endothelial factor in elderly patients with chronic heart failure[J]. Chinese Journal of General Practice, 2022, 20(12): 2006-2009. doi: 10.16766/j.cnki.issn.1674-4152.002756
Citation: ZHANG Fang, CHEN Guo-fan, REN Kai-han, WANG Ming-wei. Effects of Shexiang Baoxin Pills on cardiac function, ventricular remodeling and vascular endothelial factor in elderly patients with chronic heart failure[J]. Chinese Journal of General Practice, 2022, 20(12): 2006-2009. doi: 10.16766/j.cnki.issn.1674-4152.002756
shu

Effects of Shexiang Baoxin Pills on cardiac function, ventricular remodeling and vascular endothelial factor in elderly patients with chronic heart failure

doi: 10.16766/j.cnki.issn.1674-4152.002756

  • Cardiovascular Department, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, China

Funds:

 2021KY890

  • Received Date: 2021-04-14
    Available Online: 2023-02-07
    Abstract
  •   Objective  To analyze the effect of Shexiang Baoxin Pills on cardiac function, ventricular remodeling and vascular endothelial factor in elderly patients with chronic heart failure (CHF), so as to provide reference for clinical treatment of CHF.  Methods  A total of 100 elderly patients with CHF in the Affiliated Hospital of Hangzhou Normal University from January 2018 to December 2019 were selected and divided into control group and observation group by random digital table method, 50 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with western medicine combined with Shexiang Baoxin Pills. The cardiac function, ventricular remodeling, hemodynamics, endothelial cell function and adverse reactions were compared between the two groups.  Results  After treatment, the levels of left ventricular ejection fraction, 6 min walking test, cardiac index in the two groups were significantly higher than those before treatment (all P < 0.05), and those in the observation group were significantly higher than those in the control group [(52.16±3.39) % vs. (44.24±4.73) %, (453.46±23.20) m vs. (417.25±22.52) m, (3.34±0.38) L/(min·m2) vs. (2.88±0.46) L/(min·m2), t=9.624, 7.919, 5.452, all P < 0.05]. After treatment, the levels of the left ventricular end diastolic diameter, left ventricular posterior wall thickness, interventricular septal end systolic thickness, left ventricular mass index, pulmonary artery wedge pressure, total peripheral resistance, angiotensin Ⅱ, aldosterone, endothelin-1 in the two groups were significantly lower than those before treatment (all P < 0.05), and the observation group were significantly lower than the control group (t=7.440, 7.083, 3.733, 6.272, 12.507, 11.399, 9.234, 7.876, 10.218, all P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.444, P>0.05).  Conclusion  Shexiang Baoxin Pills can effectively improve endothelial function, cardiac function and hemodynamics in elderly patients with CHF, delay ventricular remodeling, and has good safety.

     

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