Volume 20 Issue 12
Dec.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(12): 2059-2062
CHEN Dong, FENG Jun, SU Hao, ZHANG Jing. Clinical value of plasma adiponectin in the diagnosis of chronic heart failure[J]. Chinese Journal of General Practice, 2022, 20(12): 2059-2062. doi: 10.16766/j.cnki.issn.1674-4152.002769
Citation: CHEN Dong, FENG Jun, SU Hao, ZHANG Jing. Clinical value of plasma adiponectin in the diagnosis of chronic heart failure[J]. Chinese Journal of General Practice, 2022, 20(12): 2059-2062. doi: 10.16766/j.cnki.issn.1674-4152.002769
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Clinical value of plasma adiponectin in the diagnosis of chronic heart failure

doi: 10.16766/j.cnki.issn.1674-4152.002769
  • 1.

    Department of Cardiology, the Second People' s Hospital of Hefei (Hefei Hospital Affiliated)

Funds:

 202104j07020058

 2020xkj073

 2020byzd297

  • Received Date: 2022-03-30
    Available Online: 2023-02-07
    Abstract
  •   Objective  To investigate the clinical value of plasma adiponectin (APN) in the diagnosis of chronic heart failure (CHF).  Methods  A total of 48 patients with CHF diagnosed in Anhui Provincial Hospital from May 2018 to May 2019 were included as CHF group, and 40 healthy volunteers were included as control group. The levels of plasma APN and NT-proBNP in the two groups were compared, the left ventricular ejection fraction (LVEF) in CHF group was obtained, and the correlation between plasma APN, NT-proBNP and LVEF in CHF group was analyzed. CHF patients were divided into groups by cardiac function classification of New York Heart Association (NYHA), and plasma APN, NT-proBNP and LVEF were compared between subgroups. Plasma APN, NT-proBNP and LVEF were collected before and 3 and 6 months after treatment in CHF group, and the diagnostic value of APN in CHF was preliminarily analyzed.  Results  In the CHF group, the age was 45-91 (60.98±13.98) years, with 34 males and 14 females. In the control group, the age was 51-93 (57.88±13.76) years, with 28 males and 12 females. The plasma APN and NT-proBNP in the CHF group were (23.08±9.39) μg/mL, 5 455.00 (1 256.00, 8 552.25) pg/mL, respectively, which were higher than those in the control group [(12.06±3.28) μg/mL and 55.50 (32.00, 78.50) pg/mL], the differences were statistically significant (all P < 0.05). Pearson linear relationship analysis showed that the plasma APN was positively correlated with NT-pro BNP and negatively correlated with LVEF in the CHF group. The APN and NT-proBNP increased significantly with the increase of cardiac function grade, but LVEF decreased significantly. During the follow-up, the plasma APN and NT-proBNP decreased significantly with the improvement of the disease, but LVEF increased significantly.  Conclusion  The plasma APN is positively correlated with NT-proBNP and negatively correlated with LVEF in patients with CHF, which is consistent with NYHA cardiac function grade. It has certain predictive value for clinical diagnosis of CHF.

     

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