Volume 21 Issue 1
Jan.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(1): 19-23
TUERSUNAYI·Yisimitila, ALIMIJIANG·Abulimiti, MAIHEFURETI·Wufuer, YUAN Yu-juan, PATIGULI·Kadierjiang, MUYESAI·Nijati. IL-33/ST2 pathway in atherosclerosis: the IL-33 paradox[J]. Chinese Journal of General Practice, 2023, 21(1): 19-23. doi: 10.16766/j.cnki.issn.1674-4152.002802
Citation: TUERSUNAYI·Yisimitila, ALIMIJIANG·Abulimiti, MAIHEFURETI·Wufuer, YUAN Yu-juan, PATIGULI·Kadierjiang, MUYESAI·Nijati. IL-33/ST2 pathway in atherosclerosis: the IL-33 paradox[J]. Chinese Journal of General Practice, 2023, 21(1): 19-23. doi: 10.16766/j.cnki.issn.1674-4152.002802
shu

IL-33/ST2 pathway in atherosclerosis: the IL-33 paradox

doi: 10.16766/j.cnki.issn.1674-4152.002802
  • 1.

    Emergency Department, Xinjiang Uygur Autonomous Region People ' s Hospital, Urumqi, Xinjiang 830000, China

Funds:

 81760068

  • Received Date: 2022-07-21
    Available Online: 2023-04-07
    Abstract
  •   Objective  This study aimed to investigate the relationship between the IL-33/soluble growth stimulation expressed gene 2 (ST2) pathway and coronary arteriosclerosis in human and animal models.   Methods  The clinical trial included patients with a clear diagnosis of acute myocardial infarction (AMI group, n=50) and stable coronary artery disease (CAD group, n=50) who visited the Department of Cardiology, People ' s Hospital of Xinjiang Uygur Autonomous Region from January 2019 to December 2019. Coronary blood specimens were collected from the study subjects, and IL-33 levels were detected by ELISA. In the animal experimental model, blood was collected from inferior vena cava of ApoE knockout mice, TG and cholesterol (CHOL) concentrations were measured. In addition, the thrombin-antithrombin complex (TAT) levels of the samples were calculated by ELISA.  Results  IL-33 and Gensini scores in AMI group were significantly higher than those in CAD group (all P < 0.05). Pearson correlation analysis showed a positive correlation between Gensini score and IL-33 level expression (P < 0.05). Multiple linear regression analysis showed that Gensini score levels were independently correlated with IL-33 (β=0.295, P=0.001) levels. The area under the curve (AUC) of the Gensini score, the AUC for IL-33, Gensini score and joint predictors were 0.716, 0.820 and 0.864, respectively. In the animal experimental model, the TAT concentration, TG and CHOL concentrations in ApoE knockout mice decreased with the increase of intervention time after different concentrations of IL-33 intervention (all P < 0.05).  Conclusion  Coronary blood IL-33 in patients with AMI accelerates the progression of atherosclerosis through the IL-33/ST2 pathway and induces thrombosis. IL-33 reduces lipids in atherosclerotic ApoE mice to inhibit the progression of atherosclerosis.

     

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