Volume 21 Issue 1
Jan.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(1): 50-53
CHENG Chen, YU Wen-ke, CHEN Yong, YU Xin-feng, LU Xiao-dong. Clinical and radiological analysis of subacute combined degeneration caused by different etiologies[J]. Chinese Journal of General Practice, 2023, 21(1): 50-53. doi: 10.16766/j.cnki.issn.1674-4152.002809
Citation: CHENG Chen, YU Wen-ke, CHEN Yong, YU Xin-feng, LU Xiao-dong. Clinical and radiological analysis of subacute combined degeneration caused by different etiologies[J]. Chinese Journal of General Practice, 2023, 21(1): 50-53. doi: 10.16766/j.cnki.issn.1674-4152.002809
shu

Clinical and radiological analysis of subacute combined degeneration caused by different etiologies

doi: 10.16766/j.cnki.issn.1674-4152.002809
  • 1.

    Department of Neurology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, China

Funds:

 2021ZB224

  • Received Date: 2022-07-11
    Available Online: 2023-04-07
    Abstract
  •   Objective  This study aims to compare the clinical, radiological features and outcomes between patients with subacute combined degeneration (SCD) induced by recreational nitrous oxide (N2O) abuse and patients with N2O-unrelated SCD.  Methods  From January 2017 to April 2021, the clinical data of 43 patients with SCD diagnosed at Affiliated Hospital of Hangzhou Normal University, Sir Run Run Shaw Hospital Zhejiang University and Zhejiang Second Hospital were retrospectively analysed. According to the etiology, case data were divided into 23 patients with recreational N2O-induced SCD and 20 patients with N2O-unrelated SCD. The clinical and MRI features, laboratory tests and prognosis were compared between the two groups.  Results  Of the 23 patients with recreational N2O-induced SCD, the mean age of onset was lower than those with N2O-unrelated SCD [21 (19, 25) vs. 69 (62, 74) years, P < 0.001]]. The incidence of urinary and stool dysfunction was lower in the N2O-induced SCD group (34.78%, 8/23) than in the N2O-unrelated SCD group (65.00%, 13/20, P=0.048). MRI examinations indicated the N2O-induced SCD cases presented a higher incidence of cord swelling [56.52% (13/23) vs. 20.00% (4/20), P=0.015]. The mRS scores for patients with N2O-induced SCD [3.0 (2.5, 4.0)] were lower than those with N2O-unrelated SCD [4.0 (3.5, 4.0), P=0.033] at admission. Moreover, patients with N2O-induced SCD presented significantly lower mRS [2.0 (1.0, 2.0)] scores than those with N2O-unrelated SCD [3.0 (3.0, 4.0), P < 0.001] at the last follow-up visit 3 months later.  Conclusion  These findings indicated that patients with N2O-induced SCD have less severe neurological function deficit, an increased incidence of cord swelling and better prognosis.

     

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