Volume 21 Issue 1
Jan.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(1): 66-69
BAO Xue-qing, HUANG Fen, WANG Li-juan, XIA Jie, WANG Zhao-hong. Risk factors and clinical significance of pancreatic cancer[J]. Chinese Journal of General Practice, 2023, 21(1): 66-69. doi: 10.16766/j.cnki.issn.1674-4152.002813
Citation: BAO Xue-qing, HUANG Fen, WANG Li-juan, XIA Jie, WANG Zhao-hong. Risk factors and clinical significance of pancreatic cancer[J]. Chinese Journal of General Practice, 2023, 21(1): 66-69. doi: 10.16766/j.cnki.issn.1674-4152.002813
shu

Risk factors and clinical significance of pancreatic cancer

doi: 10.16766/j.cnki.issn.1674-4152.002813
  • 1.

    Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 Q18H290010

  • Received Date: 2022-06-11
    Available Online: 2023-04-07
    Abstract
  •   Objective  To collect the data on pancreatic cancer (PC), and to analyze the risk factors for pancreatic cancer, and to develop preventive measures.  Methods  A total of 256 cases of patients with PC treated in our hospital from January 2019 to December 2020 were selected as the observation group, and a total of 256 cases of patients without PC who were hospitalised in the Second Affiliated Hospital of Wenzhou Medical University during the same period were selected as the control group. Relevant clinical data of the two groups were collected, and the risk factors affecting the incidence of PC were analysed by univariate analysis and multivariate logistic regression. The clinical significance of such data was also explored.  Results  Univariate analysis showed that the proportion of men, patients with diabetes mellitus (DM), family history of PC, history of pancreatitis, family history of DM and obesity in the observation group were significantly higher than those in the control group (all P < 0.05). But the proportion of patients with DM treated with metformin in the observation group was significantly lower than that in the control group (28.77% vs. 58.97%, P < 0.05). Multivariate logistic regression analysis showed that DM, family history of DM, family history of PC, history of pancreatitis and obesity were independent risk factors for PC (OR were 2.251, 2.208, 2.252, 3.373, 3.257, respectively). 95%CI were 1.383 to 7.640, 1.016 to 4.797, 1.067 to 4.752, 1.279 to 8.899, 1.257 to 8.443, respectively. Metformin was a protective factor for PC in diabetic patients (OR was 0.451, 95%CI was 0.239 to 0.853).  Conclusion  DM, family history of DM, family history of PC, history of pancreatitis, and obesity are independent risk factors for the development of PC. Patients with these risk factors should be vigilant about the occurrence of PC, especially those with family history of DM, family history of PC, and obesity should take active prevention and treatment measures. Metformin can effectively reduce the risk of PC in DM patients, which is a protective factor for PC in DM patients.

     

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