Volume 21 Issue 1
Jan.  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(1): 84-87
LI Hui-juan, ZHEN Xing-gang, ZHANG man. Relationship between TBX21 gene polymorphism and susceptibility to asthma in Han children[J]. Chinese Journal of General Practice, 2023, 21(1): 84-87. doi: 10.16766/j.cnki.issn.1674-4152.002818
Citation: LI Hui-juan, ZHEN Xing-gang, ZHANG man. Relationship between TBX21 gene polymorphism and susceptibility to asthma in Han children[J]. Chinese Journal of General Practice, 2023, 21(1): 84-87. doi: 10.16766/j.cnki.issn.1674-4152.002818
shu

Relationship between TBX21 gene polymorphism and susceptibility to asthma in Han children

doi: 10.16766/j.cnki.issn.1674-4152.002818
  • 1.

    Henan Children' s Hospital, Zhengzhou Children' s Hospital, Department of Respiration, Children' s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, China

Funds:

 LHGJ20190928

  • Received Date: 2022-01-18
    Available Online: 2023-04-07
    Abstract
  •   Objective  To explore the polymorphism of T-box transcription factor 21 (TBX21) in children of Han nationality and analyze its association with asthma susceptibility.  Methods  A total of 190 Han asthma patients admitted to the paediatrics department of Henan Children' s Hospital from January 2019 to January 2021 were selected as the asthma group, and 135 Han children who underwent physical examination in our hospital during the same period were selected as the control group. Oral mucosa specimens were collected; single nucleotide polymorphisms (SNP) were analysed at rs9910408, rs16947078 and rs2240017 gene loci, and the genotype distribution and allele frequencies of the 3 loci, including the TBX21 gene, were compared between the two groups. The relationship between rs2240017 locus polymorphism and asthma susceptibility was analysed by logistic regression.  Results  The Hardy-Weinberg balance test showed that the distribution frequencies of rs9910408, rs16947078 and rs2240017 genotypes in the two groups of children did not shift, and the research subjects were well represented. The difference in rs2240017 genotype distribution between the asthma group and control group was statistically significant (P < 0.05), and the frequency of the C allele in the asthma group was significantly higher than that of the control group (89.47% vs. 40.37%, P < 0.05). Moreover, the frequency of the G allele was significantly lower than that of the control group (10.53% vs. 59.63%, P < 0.05). No statistically significant difference in the rs9910408 and rs16947078 genotypes distribution was observed between the two groups (P>0.05). Logistic regression analysis showed that the decrease of G/G, C/G, C/C genotypes and G allele frequencies, as well as the increase of C allele frequency of TBX21 gene rs2240017 may be the influencing factor of asthma susceptibility (P < 0.05).  Conclusion  The rs2240017 polymorphism of the TBX21 gene is closely related to asthma susceptibility.

     

    • FullText(HTML)
  • loading
    • References(16)
  • [1]
    窦晓宾, 吴铁峰, 蔡振荡. 效应T细胞、调节T细胞失衡与支气管哮喘患儿病情程度的相关性及对疾病控制情况的预测价值[J]. 中华全科医学, 2019, 17(4): 597-600. doi: 10.16766/j.cnki.issn.1674-4152.000745

    DOU X B, WU T F, CAI Z D. Correlation between effector T cell and regulatory T cell imbalance and severity of bronchial asthma in children and its predictive value for Disease Control[J]. Chinese Journal of General Practice, 2019, 17(4): 597-600. doi: 10.16766/j.cnki.issn.1674-4152.000745
    [2]
    LEMONNIER N, MELÉN E, JIANG Y, et al. A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents[J]. Allergy, 2020, 75(12): 3248-3260. doi: 10.1111/all.14314
    [3]
    POPA S C, SHIN J A. The intrinsically disordered loop in the USF1 bHLHZ domain modulates its DNA-binding sequence specificity in hereditary asthma[J]. J Phys Chem B, 2019, 123(46): 9862-9871. doi: 10.1021/acs.jpcb.9b06719
    [4]
    JIN X S, ZHENG J S. IL-4-C-590T locus polymorphism and susceptibility to asthma in children: a meta-analysis[J]. J Pediatr (Rio J), 2021, 97(3): 264-272. doi: 10.1016/j.jped.2020.05.005
    [5]
    YU X, WANG L W, HE Q, et al. Correlation study on β2-adrenergic receptor gene polymorphisms and asthma susceptibility: evidence based on 57 case-control studies[J]. Eur Rev Med Pharmacol Sci, 2019, 23(9): 3908-3925. http://doc.paperpass.com/foreign/rgArti2019192563246.html
    [6]
    ABDI E, LATIFI-NAVID S, ZAHRI S, et al. SNP-SNP interactions of oncogenic long non-coding RNAs HOTAIR and HOTTIP on gastric cancer susceptibility[J]. Sci Rep, 2020, 10(1): 16763. DOI: 10.1038/s41598-020-73682-0.
    [7]
    李献清. 变应性鼻炎及变应性鼻炎合并哮喘相关基因表达谱构建及其致病基因筛选[D]. 广州: 南方医科大学, 2016.

    LI X Q. Construction of gene expression profile of allergic rhinitis and asthma associated with allergic rhinitis and screening of pathogenic genes[D]. Guangzhou: Southern Medical University, 2016.
    [8]
    陈爱欢, 李昌崇, 赵德育, 等. 儿童支气管哮喘诊断与防治指南[J]. 中华儿科杂志, 2008, 46(10): 745-753. doi: 10.3321/j.issn:0578-1310.2008.10.006

    CHEN A H, LI C C, ZHAO D Y, et al. Guidelines for diagnosis and treatment of bronchial asthma in children[J]. Chinese Journal of Pediatrics, 2008, 46(10): 745-753. doi: 10.3321/j.issn:0578-1310.2008.10.006
    [9]
    PIVIDORI M, SCHOETTLER N, NICOLAE D L, et al. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies[J]. Lancet Respir Med, 2019, 7(6): 509-522. doi: 10.1016/S2213-2600(19)30055-4
    [10]
    LIANG Z J, TANG F L. The potency of lncRNA MALAT1/miR-155/CTLA4 axis in altering Th1/Th2 balance of asthma[J]. Biosci Rep, 2020, 40(2): BSR20190397. DOI: 10.1042/BSR20190397.
    [11]
    KUO C S, PAVLIDIS S, LOZA M, et al. T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED[J]. Eur Respir J, 2017, 49(2): 1602135. DOI: 10.1183/13993003.02135-2016.
    [12]
    ZHAO S T, SHEN W Z, YU J Y, et al. TBX21 predicts prognosis of patients and drives cancer stem cell maintenance via the TBX21-IL-4 pathway in lung adenocarcinoma[J]. Stem Cell Res Ther, 2018, 9(1): 89. doi: 10.1186/s13287-018-0820-6
    [13]
    AKBARIAN F, ATAEI M, SALEHI Z, et al. The protective role of TBX21-1514T>C polymorphism in susceptibility to multiple sclerosis[J]. Iran J Neurol, 2018, 17(3): 111-116.
    [14]
    WAN Z, TANG Y J, SONG Q Q, et al. Gene polymorphisms in VEGFA and COL2A1 are associated with response to inhaled corticosteroids in children with asthma[J]. Pharmacogenomics, 2019, 20(13): 947-955. doi: 10.2217/pgs-2019-0036
    [15]
    PENG Z, WANG W Y, WU C, et al. Correlation between TBX21 gene polymorphism and glucocorticoid in asthma control[J]. 临床肺科杂志, 2018, 23(11): 2017-2020. doi: 10.3969/j.issn.1009-6663.2018.11.019
    [16]
    WANG H L, WANG H, WU Y, et al. Association of the rs17250932, rs4794067, and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases: a meta-analysis[J]. Allergol Immunopathol (Madr), 2021, 49(3): 83-90. doi: 10.15586/aei.v49i3.80
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(9)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (193) PDF downloads(4) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return