Volume 21 Issue 1
Jan.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(1): 123-126
XIA Ji-ning, XIANG Jing. Clinical effect of Tougucao Cebaiye Decoction on androgenic alopecia and on the level of anxiety and depression[J]. Chinese Journal of General Practice, 2023, 21(1): 123-126. doi: 10.16766/j.cnki.issn.1674-4152.002827
Citation: XIA Ji-ning, XIANG Jing. Clinical effect of Tougucao Cebaiye Decoction on androgenic alopecia and on the level of anxiety and depression[J]. Chinese Journal of General Practice, 2023, 21(1): 123-126. doi: 10.16766/j.cnki.issn.1674-4152.002827
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Clinical effect of Tougucao Cebaiye Decoction on androgenic alopecia and on the level of anxiety and depression

doi: 10.16766/j.cnki.issn.1674-4152.002827

  • Department of Dermatology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang 314001, China

Funds:

 2020ZB250

  • Received Date: 2022-05-19
    Available Online: 2023-04-07
    Abstract
  •   Objective  This study aimed to observe the therapeutic effect of Tougucao Cebaiye Decoction combined with western medicine on androgenic alopecia (AGA) and its relief effect on anxiety and depression level of patients.  Methods  A total of 124 patients with AGA admitted to Jiaxing Hospital of Traditional Chinese Medicine from June 2019 to June 2021 were selected and divided into the treatment group and control group by using the random number table method, with 62 cases in each group. Both groups were given finasteride tablets and minoxidil tincture orally. On this basis, the treatment group was given Tougucao Cebaiye Decoction for 6 months. The objective indexes (total number of hair stems, variation of hair stem diameter), TCM syndrome score (alopecia, pruritus, greasy, scaly) and clinical efficacy were compared before and after treatment in two fixed observation areas (frontal horn and head). The anxiety and depression of AGA patients were analysed, and the effects of Tougucao Cebaiye Decoction on the mood of patients with AGA after treatment were compared.  Results  After treatment, the variation in vertical hair stem diameter was lower in the treatment group than in the control group (17.31±3.16 vs. 23.67±3.78, t=10.164, P < 0.001). The total number of hair stem count was higher than that in the control group (55.18±4.32 vs. 53.09±4.95, t=2.505, P=0.014), and the total number of hair stems in frontal horn was higher than that in the control group (48.83±3.24 vs. 46.66±3.37, t=3.681, P < 0.001). After treatment, the scores of alopecia, pruritus, greasy and scaly were lower in the treatment group than in the control group (all P < 0.001). The total effective rate of the treatment group was 88.71%, which was higher than that of the control group (74.19%, χ2=4.324, P=0.038). After treatment, the GAD-7 and PHQ-9 scores were lower in the treatment group than those in the control group (all P < 0.05), and the WHOQOL-BREF scores of physiology, psychology, independence and environmental domains in the treatment group were higher than those in the control group (all P < 0.001).  Conclusion  Tougucao Cebaiye Decoction combined with western medicine can effectively inhibit hair loss symptoms in patients with damp heat type AGA, improve TCM syndromes, improve therapeutic effect, alleviate anxiety and depression and improve quality of life.

     

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